Production of cyclopiazonic acid by Aspergillus flavus Link

Luk, Kin-chun; Kobbe, B; Townsend, James M.

doi:10.1128/aem.33.1.211-212.1977

Cited by 90 publications

(22 citation statements)

References 4 publications

(4 reference statements)

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“…Prolonged drought stress during the latter part of the peanut growing season has been associated with a high incidence of A. flavus invasion and concomitant aflatoxin contamination (2). The fact that CPA is also a possible metabolite of A. flavus has already been established (6). The results of our study confirm the possibility that CPA is a natural contaminant of peanuts.…”

Section: Discussionsupporting

confidence: 87%

Occurrence of Cyclopiazonic Acid in Peanuts

Lansden

Davidson

1983

Appl Environ Microbiol

111

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Samples of segregation 3 farmer stock peanuts from the 1980 southeastern United States growing season were analyzed for the presence of cyclopiazonic acid and aflatoxins. Cyclopiazonic acid appeared in 21 of 27 loose-shell kernel fractions at a range of 32 to 6,525 ,ug/kg and in 4 of 21 sound mature kernel fractions at a range of 32 to 130 ,g/kg. Aflatoxins were detected in 26 of 27 looseshell kernel fractions and in 20 of 21 sound mature kernel fractions. Cyclopiazonic acid used at 105 and 210 ,ug/kg to spike peanut samples was recovered at an average rate of 93.3%, with ranges of 89 to 119 and 166 to 221 ,ug/kg, respectively. The minimum detection limit on oxalic acid-impregnated silica gel plates was 26 ng.

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Section: Discussionsupporting

confidence: 87%

Occurrence of Cyclopiazonic Acid in Peanuts

Lansden

Davidson

1983

Appl Environ Microbiol

111

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“…Apart from Kojic acid various fungal isolates produce some other organic acids, according to some investigators, organic acids such as Malic acid (50.5M) from (Aspergillus flavus) 77 , Itaconic acid (87.32g/l )from (Aspergillus terreus) 78 , Cyclopiazonic acid from (Aspergillus tamarii) 79 and (Aspergillus flavus) 80 are obtained from several species of Aspergillus.…”

Section: Optimization Conditions On Kojic Acid Production By a Flavusmentioning

confidence: 99%

An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

Sanjotha¹,

Shivasharana²,

Manawadi³

2019

J Pure Appl Microbiol

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“…Scientific interest in CPA increased five years later: in 1977, it was demonstrated that a prolific and important food and feed contaminant Aspergillus flavus could produce CPA. Gradually, CPA research focused on the co-occurrence of CPA and aflatoxin in the food and feed chain (Dorner et al, 1983(Dorner et al, , 1984Gallagher et al, 1978;Luk et al, 1977;Morrissey et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Cyclopiazonic acid: 50th anniversary of its discovery

Ostrý¹,

Toman

Grosse

et al. 2018

WMJ

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In 1968, the mycotoxin cyclopiazonic acid (CPA) was first discovered and characterised as a chemical substance. Within the following five decades, much has been learned from the results of CPA research. CPA is produced by several Penicillium species (P. griseofulvum, P. camemberti, P. commune, P. dipodomyicola) and Aspergillus species (A. flavus, A. oryzae and A. tamarii). It is widespread on naturally contaminated agricultural raw materials. CPA has been reported to occur in food commodities (e.g. oilseeds, nuts, cereals, dried figs, milk, cheese and meat products) and to possess toxicological significance. CPA is also frequently detected in peanuts and maize; the presence of CPA and aflatoxins in maize and peanuts contaminated with A. flavus suggests that synergism may occur. CPA is toxic to several animal species, such as rats, pigs, guinea pigs, poultry and dogs. After ingesting CPA-contaminated feeds, test animals display severe gastrointestinal upsets and neurological disorders. Organs affected include the liver, kidney, heart, and digestive tract, which show degenerative changes and necrosis. Biologically, CPA is a specific inhibitor of sarco(endo)plasmic reticulum Ca2+-ATPase. Data from toxicological evaluation of aflatoxins and CPA in broiler chickens demonstrate that both aflatoxins and CPA alone and the aflatoxin-CPA combination can adversely affect broiler health. The effects of aflatoxins and CPA combination were additive in most cases.

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Production of cyclopiazonic acid by Aspergillus flavus Link

Cited by 90 publications

References 4 publications

Occurrence of Cyclopiazonic Acid in Peanuts

Occurrence of Cyclopiazonic Acid in Peanuts

An In vitro Approach for Evaluating Antimicrobial Activity and Production of Kojic Acid by Aspergillus flavus Isolated from Karwar Region

Cyclopiazonic acid: 50th anniversary of its discovery

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