Production of Crystal Suspensions for Granulation Processes

Kallies, B.; Ulrich, Joachim; König, Ax.

doi:10.1205/026387697523598

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…For instance, lasers were used to align molecules in solutions to facilitate the nucleation of specific polymorphs [32]. Other external energy sources include electric [34] and magnetic fields [35] and ultrasound [36,37]. Other external energy sources include electric [34] and magnetic fields [35] and ultrasound [36,37].…”

Section: Primary Nucleationmentioning

confidence: 99%

Fundamentals of Industrial Crystallization

Horst

Schmidt

Ulrich

2015

Handbook of Crystal Growth

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Section: Primary Nucleationmentioning

confidence: 99%

Fundamentals of Industrial Crystallization

Horst

Schmidt

Ulrich

2015

Handbook of Crystal Growth

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“…In 2007, McCausland showed that HIU can be used to produce crystalline materials for pharmaceutical uses . In general, previous research has shown that HIU can affect crystallization processes by either affecting crystal nucleation, controlling the rate of crystal growth, promoting the formation of small and even-sized crystals, and preventing fouling of surfaces by the newly formed crystals. − Early work by Sato's group in lipid systems has shown that HIU induced the crystallization of tripalmitin and cocoa butter and also promoted the formation of β′ and β crystals. − Previous research in our laboratory has shown that HIU can induce the crystallization of other fats such as anhydrous milk fat, palm kernel oil, and an all-purpose shortening . The literature provides significant information on the effect of HIU on the crystallization behavior of different molecules in aqueous systems; however, there is very little information on the effect of HIU on the crystallization kinetics, polymorphism, and rheological behavior of lipids, shortenings in particular.…”

Section: Introductionmentioning

confidence: 98%

Using High Intensity Ultrasound as a Tool To Change the Functional Properties of Interesterified Soybean Oil

Wagh

Martini

2011

J. Agric. Food Chem.

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High intensity ultrasound (HIU) was used to change the crystallization behavior, generate small crystals, and improve the texture of a low saturated shortening (interesterified soybean oil). Samples were crystallized at different temperatures (26, 28, 30, and 32 °C) without and with the application of HIU. Different acoustic power levels (110, 72, 61, 54, and 44 W) were used. Results show that higher acoustic powers had a greater effect on crystal size reduction, induced crystallization, and generated harder, more elastic and viscous materials. These effects were more significant when HIU was applied in the presence of crystals and when the sample was crystallized at 32 °C.

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“…Ultrasound can induce macroscopic flow, i.e., acoustic streaming, which can be seen as the conversion of sound energy into kinetic energy . Ultrasound also can cause microstreaming, i.e., generation of small eddies close to a solid/liquid boundary, and when crystalline materials are treated with ultrasound, acoustic energy is absorbed in the solid lattice . However, often the most important effect in liquids is that part of the energy is used to form cavitation bubbles .…”

Section: Introductionmentioning

confidence: 99%

Influence of Ultrasound on the Nucleation of Polymorphs of p-Aminobenzoic Acid

Gracin

Uusi-Penttilä

Rasmuson

2005

Crystal Growth & Design

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p-Aminobenzoic acid crystallizes in two different polymorphic forms: the α-form and the β-form. The α-form crystals are needle-shaped, while the β-form crystals have a more favorable prismatic shape. The system is enantiotropic with the transition temperature at approximately 25 °C. Below the transition temperature, the β-form is the thermodynamically stable polymorph but can only be produced at very slow supersaturation generation either in water or in ethyl acetate. In the present work, the influence of ultrasound on the nucleation of p-aminobenzoic acid polymorphs has been investigated by use of several different sonication intensities and schemes. It is shown that sonication significantly reduces the induction time for nucleation. By using controlled sonication, we were able to more reproducibly crystallize the β-form at more reasonable cooling rates. In addition, sonication is found to quite selectively favor the appearance of the β-polymorph. It is even possible to produce the pure β-form above the transition temperature where it is the metastable form and impossible to produce without sonication. The α-form structure is based on centro symmetric dimers formed by the association of carboxylic acid groups, while the β-form contains four-membered hydrogen-bonded rings of alternating amino and carboxylic acid groups. It is suggested that ultrasound disturbs the building up of the dimers in the solution and thus favors the crystallization of the β-polymorph.

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Production of Crystal Suspensions for Granulation Processes

Cited by 7 publications

References 3 publications

Fundamentals of Industrial Crystallization

Fundamentals of Industrial Crystallization

Using High Intensity Ultrasound as a Tool To Change the Functional Properties of Interesterified Soybean Oil

Influence of Ultrasound on the Nucleation of Polymorphs of p-Aminobenzoic Acid

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