Production of Clones of Lymphoid Cell Populations

Mekori, T.; Chieco-Bianci, L.; Feldman, Michaël

doi:10.1038/206367a0

Cited by 26 publications

(8 citation statements)

References 5 publications

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“…The ability of the spleen to generate these lineages de novo, but not the lymphoid lineages, after irradiation and BMT has been well established [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Influence of an Interferon Inducer on Bone Marrow Transplant Reconstitution in Irradiated, Leukemic Mice: Elevated Natural Killer Cell Numbers and Improved Life Span

Currier¹,

Miller²

1998

Nat Immun

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Interferon-γ and interferon inducers such as polyinosinic-polycytidylic acid (poly I:C) promote natural-killer (NK)-cell-mediated killing of a wide range of tumor cells both in vitro and in vivo. The aim of the present work was to administer poly I:C to irradiated, leukemic mice, both before and after syngeneic bone marrow transplant with the intent of boosting the host’s natural immunity in the critical peritransplant period. Briefly, DBA/2 mice were injected with Friend-virus-induced erythroleukemia cells. After 5 days of tumor growth, some mice received daily injections of poly I:C for the next 4 days while control, leukemic mice received the saline vehicle only. All mice were then irradiated (450 R × 2 at 4-hour intervals) and transplanted 1 day following irradiation with bone marrow from age- and sex-matched, normal DBA/2 donor mice. After transplant, daily injections of poly I:C (or vehicle) continued for 8 more days. On day 9 after transplant, treated and control mice were killed, and the total cellularity, total numbers of lymphoid cells, the total numbers of NK cells (identified by the presence of an immuno-labelled, specific cell surface marker) were obtained from both the spleen and the bone marrow. Other identically treated mice subjected, however, to several additional rounds of poly I:C treatment were sampled 3 and 6 months after irradiation and bone marrow transplant. The results indicated that (a) poly I:C administered in the peritransplant period (before and after transplant) significantly increases the absolute numbers of NK cells in both the bone marrow and spleen of the transplanted host at all time intervals studied, (b) no erythroleukemic tumor cells were found, even as late as 6 months after transplant in the poly-I:C-treated hosts in spite of the fact that poly I:C treatment in this group had been terminated more than 2 months prior to tissue sampling, and (c) survival was significantly improved by pre- and posttransplant treatment with poly I:C.

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“…The ability of the spleen to generate these lineages de novo, but not the lymphoid lineages, after irradiation and BMT has been well established [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Influence of an Interferon Inducer on Bone Marrow Transplant Reconstitution in Irradiated, Leukemic Mice: Elevated Natural Killer Cell Numbers and Improved Life Span

Currier¹,

Miller²

1998

Nat Immun

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“…The presence of antigen-sensitive cells in the original suspension is deduced from the activity of their progeny detected many days later. From this viewpoint, it is of great interest that Mekori et aZ (9) have recently reported that macroscopic colonies containing more than a million cells develop in the spleens of irradiated mice injected with lymph nodes from mice previously treated with phytohemagglutinin. However, the results presented in Fig.…”

mentioning

confidence: 99%

A Transplantation Assay for Mouse Cells Responsive to Antigenic Stimulation by Sheep Erythrocytes.

Kennedy

Siminovitch

Till

et al. 1965

Experimental Biology and Medicine

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“…Magnesium hydroxide has a sharp absorption band at a wavelength close to 2.7 /; this band is strongly developed in infrared spectra of Goniolithon (Fig. 2) The presence of brucite in the Goniolithon secretion is further substantiated by the results of a broadline nuclearmagnetic-resonance (NMR) protonspectrum study (10). The results of this study are necessarily somewhat generalized (the material examined was not a split of that subjected to chemical analysis) and their interpretation is less exact (broadline NMR cannot be used to establish the ionic form in which hydrogen ions are present in a compound).…”

Section: Rrucite In Carbonate Secreted By the Red Alga Goniolithon Spmentioning

confidence: 83%

“…Samples of well-crystallized brucite from Wakefield, Quebec, yielded a peak temperature of 400?C at the same water pressure (9). The differential thermal analysis spectrum of brucite is readily distinguished from those of other possible magnesiu mminerals such as nesquehonite and hydromagnesite (10).…”

mentioning

confidence: 99%

Brucite in Carbonate Secreted by the Red Alga Goniolithon sp.

Schmalz

1965

Science

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X-ray diffraction studies, chemical analyses, infrared-absorption studies, and nuclear-magnetic-resonance spectrum analysis demonstrate the existence of the mineral brucite, Mg(OH)(2), in the skeletal carbonate secreted by the red marine alga Goniolithon sp. Electron microprobe examination of the carbonate shows that the brucite is concentrated in certain areas of the skeletal structure. These results explain the anomalously high solubility and large cell size of the Goniolithon "carbonate" observed by earlier investigators.

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Production of Clones of Lymphoid Cell Populations

Cited by 26 publications

References 5 publications

Influence of an Interferon Inducer on Bone Marrow Transplant Reconstitution in Irradiated, Leukemic Mice: Elevated Natural Killer Cell Numbers and Improved Life Span

Influence of an Interferon Inducer on Bone Marrow Transplant Reconstitution in Irradiated, Leukemic Mice: Elevated Natural Killer Cell Numbers and Improved Life Span

A Transplantation Assay for Mouse Cells Responsive to Antigenic Stimulation by Sheep Erythrocytes.

Brucite in Carbonate Secreted by the Red Alga Goniolithon sp.

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