Production of C-reactive protein and risk of coronary events in stable and unstable angina

Haverkate, F.; Thompson, Simon G.; Pyke, Stephen; Gallimore, J. Ruth; Pepys, Mark B.

doi:10.1016/s0140-6736(96)07591-5

Cited by 1,347 publications

(347 citation statements)

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“…High-sensitivity C-reactive protein (CRP), a marker of inflammation, has been identified as an independent predictor of adverse cardiac events in healthy populations and in patients with stable coronary artery disease or ACS (6)(7)(8)(9)(10)(11). Although it is clear that inflammation plays a role in atherosclerotic complications (12), the relationship between CRP and troponin release following PCI has not been clarified.…”

mentioning

confidence: 99%

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

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mentioning

confidence: 99%

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Hubáček

Basran

Shrive

et al. 2009

Canadian Journal of Cardiology

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“…Furthermore, a substantial proportion of acute myocardial infarctions and strokes are preceded by clinical episodes of infection and͞or inflammation elsewhere in the body (2,3). In this context, considerable interest was aroused by the original reports of a prognostic association between nonspecific circulating markers of inflammation, in particular the classical acute-phase protein C-reactive protein (CRP), and future coronary events in patients with known coronary artery disease (4)(5)(6). Interest was further heightened by the demonstration that baseline measurements of CRP in ostensibly healthy individuals in the general population also significantly predicted future atherothrombotic events (7)(8)(9).…”

mentioning

confidence: 99%

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice

Hirschfield

Gallimore

Kahan

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

178

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The association between circulating concentrations of C-reactive protein (CRP) and future atherothrombotic events has provoked speculation about a possible pathogenetic role of CRP. However, we show here that transgenic expression of human CRP had no effect on development, progression, or severity of spontaneous atherosclerosis, or on morbidity or mortality, in male apolipoprotein E (apoE)-deficient C57BL͞6 mice up to 56 weeks, despite deposition of human CRP and mouse complement component 3 in the plaques. Although female apoE knockouts develop atherosclerosis more rapidly than males, the human CRP transgene is under sex hormone control and is expressed at human levels only in males. We therefore studied only male mice. The concentration of mouse serum amyloid P component, an extremely sensitive systemic marker of inflammation, remained normal throughout except for transient spikes in response to fighting in a few animals, indicating that atherogenesis in this model is not associated with an acute-phase response. However, among human CRP transgenic mice, the circulating CRP concentration was higher in apoE knockouts than in wild-type controls. The higher CRP values were associated with substantially lower estradiol concentrations in the apoE-deficient animals. Human CRP transgene expression is thus up-regulated in apoE-deficient mice, apparently reflecting altered estrogen levels, despite the absence of other systemic signs of inflammation. Extrapolation to human pathology from this xenogeneic combination of human CRP with apoE deficiency-mediated mouse atherosclerosis must be guarded. Nevertheless, the present results do not suggest that human CRP is either proatherogenic or atheroprotective in vivo.atherosclerosis ͉ inflammation ͉ transgenic

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“…Even though, no data as yet has documented a possible linkage between RPF and ACS, a common soil does probably exist, namely that these disorders share a common underlying early triggering insult that is oxidized LDL (5). Moreover, high CRP levels usually found in RPF patients have consistently been proven to predict the development of unstable angina, MI and coronary mortality especially in diabetic patients (6).…”

Section: Discussionmentioning

confidence: 99%

Left Main Coronary Artery Thrombosis Complicating an Idiopathic Retroperitoneal Fibrosis in a 37-year-old Man with Long-standing Type I Diabetes Mellitus

et al. 2010

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Retroperitoneal fibrosis is an uncommon collagen vascular disease of unknown etiology, characterized by the replacement of normal retroperitoneal tissue with fibrosis and/or chronic inflammation usually surrounding the abdominal aorta and the iliac arteries and extending into adjacent anatomic structures. No cases of acute coronary syndrome in the setting of retroperitoneal disorder have been published as yet. We report a 37-year-old man with a 14-year history of type I diabetes mellitus who was admitted to the endocrinology department for a routine check up and glycemic re-equilibration and who was later diagnosed to have an idiopathic retroperitoneal fibrosis. The patient presented during his hospitalisation with a non ST elevation myocardial infarction caused by an isolated thrombus located inside the left main coronary artery successfully treated with manual thrombectomy.

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Production of C-reactive protein and risk of coronary events in stable and unstable angina

Cited by 1,347 publications

References 24 publications

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Prognostic implications of C-reactive protein and troponin following percutaneous coronary intervention

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice

Left Main Coronary Artery Thrombosis Complicating an Idiopathic Retroperitoneal Fibrosis in a 37-year-old Man with Long-standing Type I Diabetes Mellitus

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