Production of C‐phycocyanin and its potential applications

Kuddus, Mohammed; Singh, Poonam; Thomas, George; Ali, Athar

doi:10.1002/9781118733103.ch12

Cited by 6 publications

(3 citation statements)

References 95 publications

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“…PCB is composed of a linear tetrapyrrole structure, and it forms the prosthetic group of the protein. Phycocyanin is known for its various pharmacological activities, including its use as a food coloring agent, as well as its reported anticancer, antioxidant, anti‐inflammatory, neuroprotective, hepatoprotective, hypocholesterolemic, and radical‐scavenging properties (Kuddus et al., 2015). The degree of purity of phycocyanin, expressed as the ratio of the absorbance value obtained at 620 nm to the total protein absorbance value obtained at 280 nm, is a critical parameter that determines its application (Moraes et al., 2011).…”

Section: Biochemical Composition Of S Platensis and P Tricornutummentioning

confidence: 99%

Spirulina platensis and Phaeodactylum tricornutum as sustainable sources of bioactive compounds: Health implications and applications in the food industry

Uzlaşır,

Selli,

Kelebek

2024

Future Postharvest and Food

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The exponential growth of the global population, coupled with issues of insufficient and imbalanced nutrition, as well as a surge in health‐related problems, has compelled individuals to seek innovative and alternative food sources while optimizing existing resources. Microalgae have been a staple source of livelihood and essential nourishment for people in various regions worldwide. Their rich content of proteins, essential amino acids, carbohydrates, lipids, vitamins, and minerals necessary for nutrition, has made them a fundamental source of sustenance. Spirulina platensis (S. platensis), a single‐celled, filamentous, prokaryotic microalgae, has long been recognized as a valuable natural food source, with historical usage dating back to ancient times. On the other hand, Phaeodactylum tricornutum (P. tricornutum), although a freshwater species, belongs to the Pennateae group of single‐celled eukaryotic diatoms and exhibits adaptability to marine environments. S. platensis and P. tricornutum have recently gained attention due to their abundant bioactive compounds, including carotenoids and phenolic acids. These bioactive compounds are known for their potential health benefits, including anticancer, antioxidant, anti‐inflammatory, neuroprotective, hepatoprotective, and hypocholesterolemic properties. This review examines the bioactive compounds produced by S. platensis and P. tricornutum, their impacts on human health, and their promising applications within the food industry.

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Section: Biochemical Composition Of S Platensis and P Tricornutummentioning

confidence: 99%

Spirulina platensis and Phaeodactylum tricornutum as sustainable sources of bioactive compounds: Health implications and applications in the food industry

Uzlaşır,

Selli,

Kelebek

2024

Future Postharvest and Food

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“…It is water-soluble, located in the cytoplasmic membrane, and released outside when the thylakoid membrane is destroyed by lysozyme enzyme and EDTA chelate cations [9,10]. PC can be extracted using organic and inorganic solvents, ultrasound, enzyme homogenization, freezing, and thawing from Spirulina [11,12]. PC possesses antioxidant, radical scavenging, anti-inflammatory, antiarthritic, hepatoprotective, antitumor, and immune-enhancing properties [6,13].…”

Section: Introductionmentioning

confidence: 99%

Modulating the Growth, Antioxidant Activity, and Immunoexpression of Proinflammatory Cytokines and Apoptotic Proteins in Broiler Chickens by Adding Dietary Spirulina platensis Phycocyanin

et al. 2022

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This study investigated the dietary effect of Spirulina platensis phycocyanin (SPC) on growth performance (body weight (BW), body weight gain (BWG), feed intake (FI), feed conversion ratio (FCR)) at starter, grower, and finisher stages, intestinal histomorphology, serum biochemical parameters, inflammatory and antioxidant indices, and proinflammatory cytokines (tumor necrosis factor-α and caspase-3) immune expression in broiler chickens. In total, 250 one-day-old chicks (Ross 308 broiler) were randomly allotted to five experimental groups (5 replicates/group, 10 chicks/replicate) and fed basal diets supplemented with five levels of SPC (0, 0.25, 0.5, 0.75, and 1 g kg–1 diet) for 35 days. Compared with SPC0 treatment, different SPC levels increased the overall BW and BWG without affecting the total feed consumption. However, the FCR decreased linearly with an increase in supplementation level. The serum levels of total proteins, albumin, globulins, and growth hormone increased linearly by increasing levels of SPC supplementation. Further, SPC supplementation increased the thyroxin hormones without affecting serum glucose and leptin levels. Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) values decreased in broilers fed SPC0.250 and SPC1 diets. Triglycerides (TG) decreased in SPC0.25-, SPC0.75-, and SPC1-treated groups. Though antioxidant enzyme activities (total antioxidant capacity, catalase, and superoxide dismutase) increased linearly and quadratically, malondialdehyde (MDA) decreased linearly by increasing the SPC level. There was no effect on serum proinflammatory cytokines IL1β levels. Immunolabelling index of caspase-3 and tumor necrosis factor-α (TNF-α) were downregulated by SPC supplementation. The intestinal histomorphology is represented by increased villus height, the villus height to crypt depth ratio, and numbers of goblet cells in different sections of the small intestine. In conclusion, SPC supplementation is beneficial in broiler chicken diets due to its growth-promoting, antioxidant, and anti-inflammatory properties.

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“…Purification is performed by extraction with ammonium sulfate, while separation is generally achieved by the column chromatographic methods using adsorbents, anion exchangers or gel filtration chromatography. Freeze drying is considered to be the most suitable method for pigment drying [12]. The purity of C-PC is usually established by dividing C-PC absorbance at a wavelength of its absorption maximum at 620 nm to a specific absorbance at a wavelength of 280 nm, which is related to the total protein, especially aromatic amino acids (A620/A280).…”

Section: Introductionmentioning

confidence: 99%

Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

Dranseikienė

Balčiūnaitė-Murzienė

Karosienė

et al. 2022

Plants

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Cyano-phycocyanin is one of the active pigments of the blue-green algae and is usually isolated from the filamentous cyanobacteria Arthrospira platensis Gomont (Spirulina). Due to its multiple physiological functions and non-toxicity, cyano-phycocyanin may be a potential substance for the topical treatment of various skin diseases. Considering that the conventional medicine faces drug resistance, insufficient efficacy and side effects, the plant origin compounds can act as an alternative option. Thus, the aim of this paper was to review the wound healing, antimicrobial, antioxidative, anti-inflammatory, antimelanogenic and anticancer properties and mechanisms of cyano-phycocyanin topical activities on human skin. Moreover, possible applications and biotechnological requirements for pharmaceutical forms of cyano-phycocyanin for the treatment of various skin diseases are discussed in this review.

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Production of C‐phycocyanin and its potential applications

Cited by 6 publications

References 95 publications

Spirulina platensis and Phaeodactylum tricornutum as sustainable sources of bioactive compounds: Health implications and applications in the food industry

Spirulina platensis and Phaeodactylum tricornutum as sustainable sources of bioactive compounds: Health implications and applications in the food industry

Modulating the Growth, Antioxidant Activity, and Immunoexpression of Proinflammatory Cytokines and Apoptotic Proteins in Broiler Chickens by Adding Dietary Spirulina platensis Phycocyanin

Cyano-Phycocyanin: Mechanisms of Action on Human Skin and Future Perspectives in Medicine

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