Production of biodegradable porous scaffolds impregnated with indomethacin in supercritical CO2

Drug loading of polymer implants by supercritical CO 2 assisted impregnation: A review

“…When the polymer is subjected to scCO 2 , its glass transition T g and its melting point T m are decreased in situ and more CO 2 can be sorbed into the polymer. During depressurization, the CO 2 bubbles growth and nucleate resulting in the formation of a porous structure [39,40]. Fanovich et al explored the use of the scCO 2 to impregnate an antibacterial agent in poly(ε-caprolactone) and then foam the sample [45].…”

“…Thanks to UV-vis or infrared or Raman analysis, the establishment of hydrogen bonding between polymers and drugs have been referred in many systems such as {chitosan + quercetin}, {PMMA + ibuprofen}, {PMMA + triflusal}, {PVP + ketoprofen}, {acrylic based hydrogel + flurbiprofen}, {acrylic based hydrogel + norfloxacin}, {P(D,L)LA + indomethacin}, and {PLGA + indomethacin}[24,33,34,[39][40][41]49,52,58].…”

Drug Loading of Sutures by Supercritical CO2 Impregnation: Effect of Polymer/Drug Interactions and Thermal Transitions

“…Moreover, since the supercritical state of CO 2 can be reached at a reasonable temperature, this process remains compatible with thermosensitive API. ScCO 2 has been widely used to incorporate API into various polymer implants and medical devices, such as intraocular lenses, contact lenses, sutures, and scaffolds for tissue engineering …”

Collagen-Indomethacin-Hydroxyapatite Spongious Forms for Bone Reconstruction Treatment

“…Indomethacin (IND) is a nonsteroidal anti-inflammatory drug commonly used as a prescription medication to reduce fever, for pain, stiffness, and swelling from inflammation. It works by inhibiting the production of prostaglandins, molecules known to cause these symptoms and ease the pain and discomfort (Cabezas, 2012).…”