The aim of this study was to prepare and characterize collagen spongious forms for bone tissue engineering. The ideal scaffold has almost the same structural and biological functions as a naturally occurring extracellular matrix in terms of physical structure and chemical composition Having about 30% collagen and 70% hydroxyapatite, to mimic bone composition, the obtained matrices were characterized by water up-take, enzymatic degradation, scanning electron microscopy and indomethacin release from supports. The results showed that the composites based on collagen and hydroxyapatite absorbed less water than the ones with indomethacin. The degradation process showed that indomethacin inhibits collagenase solution, degradation taking place in more than one week. The pore sizes are proper for bone tissue engineering and the release of drug is fast in first 4 hours and slowly next hours. The results showed us that the combination between collagen, indomethacin and hydroxyapatite is a promising spongious form, slowly degraded in vitro, with specific absorbance properties, with proper pore sizes and porosity and which can release the drug rapidly, ensuring a diminution of the inflammation and of the associated pain; this formulation could be successfully used in bone regeneration.
Cataract is one of the most common causes of blindness for people over 40 years old. Hydrogels are three -dimensional structures with increased properties which can be successful used in medical application such prosthesis or intraocular soft contact lenses. Sodium carboxymethylcellulose (CMC -Na) is the cheaper option currently available on the market with properties like biocompatibility similar with pHEMA. The aim of this study was to develop polymeric crystalline materials based on collagen (COL) and carboxymethylcellulose cross-linked with EDC/NHS for cataracts or other eye-disease. Type I fibrillar collagen gel with various ratios of CMC-Na hydrogels were lyophilized and tests tested by optic and scanning electronic microscopy, FT-IR spectroscopy and water absorption. The obtained gels were crosslinked with EDC/NHS and lyophilized in order to obtain spongious forms. They are porous structures with pore sizes between 25-81 µm. The samples with CMCNa presented more uniform and dense matrices and the crosslinked ones are more resistant, being more proper as material for lenses for be used in cataract.
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