Production of 2-phenylethyl acetate via reactive distillation

Šulgan, Branislav; Labovská, Zuzana; Markoš, Jozef

doi:10.1007/s11696-020-01082-9

Cited by 5 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2] For instance, the price of natural PEA and Et-PA are 1760-2200 USD kg À 1 . [3] Several chemical methods were established for the synthesis of PEA, [4] PAA, [5] Et-PA, [6] and PE-PA. [7] These chemical syntheses start from petroleum-derived chemicals, require the use of toxic reagents, and generate by-products and large amount of waste. [1c] In addition, the generated by-products affect the aroma and organoleptic profiles for flavor applications.…”

Section: Introductionmentioning

confidence: 99%

Bioproduction of Natural Phenethyl Acetate, Phenylacetic Acid, Ethyl Phenylacetate, and Phenethyl Phenylacetate from Renewable Feedstock

Sekar

Zhi

2022

ChemSusChem

View full text Add to dashboard Cite

Natural phenethyl acetate (PEA), phenylacetic acid (PAA), ethyl phenylacetate (Et‐PA), and phenethyl phenylacetate (PE‐PA) are highly desirable aroma chemicals, but with limited availability and high price. Here, green, sustainable, and efficient bioproduction of these chemicals as natural products from renewable feedstocks was developed. PEA and PAA were synthesized from l‐phenylalanine (l‐Phe) via novel six‐ and five‐enzyme cascades, respectively. Whole‐cell‐based cascade biotransformation of 100 mm l‐Phe in a two‐phase system (aqueous/organic: 1 : 0.5 v/v) containing ethyl oleate or biodiesel as green solvent gave 13.6 g L−1 PEA (83.1 % conv.) and 11.6 g L−1 PAA (87.1 % conv.), respectively. Coupled fermentation and biotransformation approach produced 10.4 g L−1 PEA and 9.2 g L−1 PAA from glucose or glycerol, respectively. The biosynthesized PAA was converted to natural Et‐PA and PE‐PA by esterification using lipases with ethanol or 2‐phenylethanol derived from sugar, affording 2.7 g L−1 Et‐PA (83.1 % conv.) and 4.6 g L−1 PE‐PA (96.3 % conv.), respectively.

show abstract