Production of 117mSn with high specific activity by cyclotron

Maslov, O. D.; Starodub, G. Ya.; Vostokin, G. K.; Gustova, M. V.; Dmitriev, S.N.; Швецов, В. Н.; Szűcs, Zoltán; Jansen, David R.; Zeevaart, Jan Rijn

doi:10.1016/j.apradiso.2011.02.031

Cited by 18 publications

(6 citation statements)

References 7 publications

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“…Our new data are somewhat higher than the previous results of (Fukushima et al, 1963) and lower than the recent data of (Khandaker et al, 2014). There is another experimental result for the thick target yield in the literature from (Maslov et al, 2011). They used a limited target thickness at the 35 MeV bombarding energy.…”

Section: Thick Target Yieldscontrasting

confidence: 63%

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

Ditrói

Takács

Haba

et al. 2016

Applied Radiation and Isotopes

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Cross sections of alpha particle induced nuclear reactions have been measured on thin natural cadmium targets foils in the energy range from 11 to 51.2MeV. This work was a part of our systematic study on excitation functions of light ion induced nuclear reactions on different target materials. Regarding the cross sections, the alpha induced reactions are not deeply enough investigated. Some of the produced isotopes are of medical interest, others have application in research and industry. The radioisotope Sn is a very important theranostic (therapeutic + diagnostic) radioisotope, so special care was taken to the results for that isotope. The well-established stacked foil technique followed by gamma-spectrometry with HPGe gamma spectrometers were used. The target and monitor foils in the stack were commercial high purity metal foils. From the irradiated targetsSn, Sn,Sn, In,In, In,In, In,In, In,In, In,Cd and Cd were identified and their excitation functions were derived. The results were compared with the data of the previous measurements from the literature and with the results of the theoretical nuclear reaction model code calculations TALYS 1.8 (TENDL-2015) and EMPIRE 3.2 (Malta). From the cross section curves thick target yields were calculated and compared with the available literature data.

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Section: Thick Target Yieldscontrasting

confidence: 63%

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

Ditrói

Takács

Haba

et al. 2016

Applied Radiation and Isotopes

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“…8 together with the available experimental data from the literature, measured on enriched 116 Cd target. For 117m Sn production a previous result was reported by Maslov et al [32]. They measured on 95% enriched 116 Cd target with a thickness of 0.01107 g/cm2, by using 35 MeV bombarding energy.…”

Section: Thick Target Yieldsmentioning

confidence: 68%

Excitation function of the alpha particle induced nuclear reactions on enriched 116Cd, production of the theranostic isotope 117mSn

Ditrói¹,

Takács²,

Haba³

et al. 2016

Nuclear Instruments and Methods in Physics Research Section B:

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117m Sn is one of the radioisotopes can be beneficially produced through alpha particle irradiation. The targets were prepared by deposition of 116 Cd metal onto high purity 12 µm thick Cu backing. The average deposited thickness was 21.9 µm. The beam energy was thoroughly measured by Time of Flight (TOF) methods and proved to be 51.2 MeV. For the experiment the well-established stacked foil technique was used. In addition to the Cd targets, Ti foils were also inserted into the stacks for energy and intensity monitoring. The Cu backings were also used for monitoring and as recoil catcher of the reaction products from the cadmium layer. The activities of the irradiated foils were measured with HPGe detector for gamma-ray spectrometry and cross section values were determined. As a result excitation functions for the formation of 117m Sn, 117m,g In, 116m In, 115m In and 115m,g Cd from enriched 116 Cd were deduced and compared with the available literature data and with the results of the nuclear reaction model code calculations EMPIRE 3.2 and TALYS 1.8. Yield curves were also deduced for the measured nuclear reactions and compared with the literature.

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“…117m Sn is produced either by neutron activation using enriched 116 Sn target, via the 116 Sn(n,γ) 117m Sn nuclear reaction or by inelastic neutron scattering on enriched 117 Sn, 117 Sn(n,n',γ) 117m Sn (Das and Pillai, 2013;Maslov et al, 2011). However, owing to the poor crosssection of both these reactions and the need for a very high flux reactor and highly enriched targets that are essential to produce sufficient quantities of 117m Sn, large-scale production of this radionuclide is not practical.…”

Section: Iid Tin-117mmentioning

confidence: 99%

“…Moreover, the low specific activity of the produced 117m Sn can be a limiting factor for radiolabelling of target compounds (Srivastava, 2013). Additional accelerator based production routes have been investigated to produce no carrier added (nca) 117m Sn, using 3 He particle-induced reactions on 116 Cd and 115 In (Maslov et al, 2011;Srivastava, 2013). However, these reactions could provide only low yield.…”

Section: Iid Tin-117mmentioning

confidence: 99%

Palliative treatment of metastatic bone pain with radiopharmaceuticals: A perspective beyond Strontium-89 and Samarium-153

Liberal

Tavares

2016

Applied Radiation and Isotopes

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Purpose: The present review article aims to provide an overview of the available radionuclides for palliative treatment of bone metastases beyond 89 Sr and 153 Sm. In addition, it aims to review and summarize the clinical outcomes associated with the palliative treatment of bone metastases using different radiopharmaceuticals. Materials and Methods: A literature search was conducted on Science Direct and PubMed databases (1990 -2015). The following search terms were combined in order to obtain relevant results: "bone", "metastases", "palliative", "care", "therapy", "treatment", "radiotherapy", "review", "radiopharmaceutical", "phosphorus-32", "strontium-89", "yttrium-90", "tin-117m", "samarium-153", "holmium-166", "thulium-170", "lutetium-177", "rhenium-186", "rhenium-188" and "radium-223". Studies were included if they provided information regarding the clinical outcomes. Results and Conclusions: A comparative analysis of the measured therapeutic response of different radiopharmaceuticals, based on previously published data, suggests that there is a lack of substantial differences in palliative efficacy among radiopharmaceuticals. However, when the comparative analysis adds factors such as patient's life expectancy, radionuclides' physical characteristics (e.g. tissue penetration range and half-life) and health economics to guide the rational selection of a radiopharmaceutical for palliative treatment of bone metastases, 177 Lu and 188 Re-labeled radiopharmaceuticals appear to be the most suitable radiopharmaceuticals for treatment of small and medium/large size bone lesions, respectively.

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Production of 117mSn with high specific activity by cyclotron

Cited by 18 publications

References 7 publications

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

Excitation function of the alpha particle induced nuclear reactions on enriched 116Cd, production of the theranostic isotope 117mSn

Palliative treatment of metastatic bone pain with radiopharmaceuticals: A perspective beyond Strontium-89 and Samarium-153

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