Excitation function of the alpha particle induced nuclear reactions on enriched 116Cd, production of the theranostic isotope 117mSn

Abstract

117m Sn is one of the radioisotopes can be beneficially produced through alpha particle irradiation. The targets were prepared by deposition of 116 Cd metal onto high purity 12 µm thick Cu backing. The average deposited thickness was 21.9 µm. The beam energy was thoroughly measured by Time of Flight (TOF) methods and proved to be 51.2 MeV. For the experiment the well-established stacked foil technique was used. In addition to the Cd targets, Ti foils were also inserted into the stacks for energy and intensity monitoring. The Cu backings were also used for monitoring and as recoil catcher of the reaction products from the cadmium layer. The activities of the irradiated foils were measured with HPGe detector for gamma-ray spectrometry and cross section values were determined. As a result excitation functions for the formation of 117m Sn, 117m,g In, 116m In, 115m In and 115m,g Cd from enriched 116 Cd were deduced and compared with the available literature data and with the results of the nuclear reaction model code calculations EMPIRE 3.2 and TALYS 1.8. Yield curves were also deduced for the measured nuclear reactions and compared with the literature.

Development of novel radionuclides for medical applications

“…The nuclear processes for its production have been reviewed . In general, attempts have been made to obtain no‐carrier‐added 117m Sn via 3 He‐ and α particle–induced reactions on isotopes of In and Cd, as well as via proton‐induced reactions on Sb . The integral yields of 117m Sn from all those reactions have been recently reported .…”

“…obtain no-carrier-added 117m Sn via 3 He-and α particleinduced reactions on isotopes of In and Cd, [141][142][143][144] as well as via proton-induced reactions on Sb. 145 The integral yields of 117m Sn from all those reactions have been recently reported.…”

Cross section measurement of alpha particle induced nuclear reactions on natural cadmium up to 52 MeV

“…Our interest for cadmium was induced by its use as target material in order to produce some medically and industrially important radioisotopes. Among these radioisotopes the most important is the so called theranostic (therapeutic + diagnostic) radioisotope 117m Sn (Baum, 2014;Ditrói et al, 2016;Stevenson et al, 2015), but it has also nononcological use in the medicine (Simon et al, 2013;Stevenson et al, 2015). The diagnostic applicability is based on its good detectable gamma-lines and reasonable half-life (T 1/2 = 13.76 d) (Knapp et al, 1983;NuDat, 2014).…”

“…For estimation of the contaminating amount of different radioisotopes it is necessary to use the experimental results on natural target composition. Earlier studies of alpha particle induced reactions mainly targeted the production of medically important radioisotopes, such as 117m Sn (Andreyev et al, 1999;Ditrói et al, 2016;Fukushima et al, 1963;Knapp et al, 1983;Qaim and Dohler, 1984) but there are also studies giving experimental data for all detectable radio-products (Adam-Rebeles et al, 2008;Hermanne et al, 2010;Qaim, 2015;Qaim and Dohler, 1984).…”