Production des cytokines Th1/Th2 et du monoxyde d′azote au cours de l’uvéite « Behçet » et de l’uvéite « idiopathique »

Guenane, H.; Hartani, D.; Chachoua, L.; Lahlou-Boukoffa, O.S.; Mazari, F.; Touil-Boukoffa, Chafia

doi:10.1016/s0181-5512(06)73762-7

Cited by 42 publications

(8 citation statements)

References 25 publications

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“…As a non-specific cytokine, increasing in the level of IL-12 were demonstrated in idiopathic uveitis and BD uveitis in Guenane et al’s study, which shows its role in uveitis regardless of the underlying disease. These findings contrast with those of Ahn et al’s study [4,21]. According to our findings, VEGF, TNFα, and IFNγ had no role in BD uveitis [4,14,21].…”

Section: Discussioncontrasting

confidence: 99%

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Serum Profiles of Cytokines in Behcet’s Disease

Sadeghi

Davatchi

Shahram

et al. 2017

JCM

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Introduction: Behcet’s disease (BD) is a chronic systemic autoinflammatory vasculitis which is handled by the variety of proteins like cytokines. Therefore, cytokines are considered as one of the prototypic factors during inflammatory responses of BD. Consequently, the present study was designed for evaluation of cytokine profiles in Iranian BD cases, including those with and without uveitis. Materials and Method: All cases were divided into three groups based on ophthalmologic exam results: BD with uveitis, BD without uveitis, and recovered uveitis BD. Cases with a history of BD recovery were placed in the group of recovered uveitis. The patients with infectious uveitis as well as other collagen vascular diseases and patients who have used biologics to treat ocular immune-mediated diseases were excluded. Finally, after venous blood sampling, levels of cytokines were quantified and statistical approaches were performed for measurements. Results: Enrolled cases were divided to 26 patients with active uveitis, 25 patients with recovered uveitis and 24 patients without uveitis and interestingly, just IL-2 was the only cytokine that showed statistical difference in patients with BD uveitis in comparison with other groups (pvalue = 0.02). The pair wise comparison showed a significant difference between the patients with and without uveitis groups (pvalue = 0.004) as well as patients with uveitis and recovered uveitis groups (pvalue = 0.002). Discussion: Significant elevation of IL-2 in patients with uveitis (in comparison with recovered or without uveitis cases) demonstrates that it may be one of the main proteins that enroll in the pathophysiology of BD uveitis and may be considered as a new target for refractory disease therapies. Studies with larger samples can help to obtain more accurate conclusions.

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Section: Discussioncontrasting

confidence: 99%

“…These findings contrast with those of Ahn et al’s study [4,21]. According to our findings, VEGF, TNFα, and IFNγ had no role in BD uveitis [4,14,21]. Furthermore, IFNγ could be considered as a non-specific cytokine in uveitis according to findings described in [22].…”

Section: Discussioncontrasting

confidence: 99%

Serum Profiles of Cytokines in Behcet’s Disease

Sadeghi

Davatchi

Shahram

et al. 2017

JCM

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“…Two others cytokines, IL-23 and IL-12, may play an important role in BD pathogenesis; their levels are elevated in BD patients (44–46). IL-23 drives and promotes the development of a unique T-helper cell population that produces IL-17, Th17 cells.…”

Section: Introductionmentioning

confidence: 99%

Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet’s Disease Risk in Western Algeria

et al. 2013

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Objective: We have conducted the first study of the association of interleukin (IL)-10, tumor necrosis factor alpha (TNF-α), and IL23R-IL12RB2 region single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in Western Algeria.Methods: A total of 51 BD patients and 96 unrelated controls from West region of Algeria were genotyped by direct sequencing for 11 SNPs including 2 SNPs from the IL10 promoter [c.-819T > C (rs1800871), c.-592A > C (rs1800872)], 6 SNPs from the TNF-α promoter [c.-1211T > C (rs1799964), c.-1043C > A (rs1800630), c.-1037C > T (rs1799724), c.-556G > A (rs1800750), c.-488G > A (rs1800629), and c.-418G > A (rs361525)], and 3 SNPs from the IL23R-IL12RB2 region [g.67747415A > C (rs12119179), g.67740092G > A (rs11209032), and g.67760140T > C (rs924080)].Results: The minor alleles c.-819T and c.-592A were significantly associated with BD [odds ratio (OR) = 2.18; 95% confidence interval (CI) 1.28–3.73, p = 0.003]; whereas, there was weaker association between TNF-α promoter SNPs or IL23R-IL12RB2 region and disease risk.Conclusion: Unlike the TNF-α and the IL23R-IL12RB2 region SNPs, the two IL10 SNPs were strongly associated with BD. The -819T, and -592A alleles and the -819TT, -819CT, and -592AA and -592CA genotypes seem to be highly involved in the risk of developing of BD in the population of Western Algeria.

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“…These reactions have functional consequences which may be deleterious [11,12]. The large amounts of NO production have been shown to be correlated with pathophysiology in a plethora of diseases and inflammation processes, such as bowel inflammatory disease [13] and Adamantiades-Behçet's disease [14]. Consequently, the development of molecules aimed to prevent the overproduction of NO constitutes an interesting area of research of a new treatment of chronic inflammatory diseases [15-18].…”

Section: Introductionmentioning

confidence: 99%

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

et al. 2011

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BackgroundAdamantiades-Behçet's disease (ABD) is a chronic multisystemic inflammation with unknown pathophysiology. This disorder is associated with a dysregulation of the cytokine network that hyperactivates neutrophils and macrophages. In this study, we investigate the modulatory effects of flavonoïd compounds extracted from Algerian medicinal plant Artemisia herba alba on Th1 and Th2 cytokines and nitric oxide production.MethodsThe modulatory effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production by peripheral blood mononuclear cells isolated from Algerian ABD patients and healthy controls were respectively measured by means of ELISA assays and Griess modified method.ResultsOur results show that flavonoïds significantly reduce the production of interleukin-12, the key effector of T helper 1 (Th1) cells and nitric oxide in a dose-dependent manner in Adamantiades-Behçet's disease. In contrast, the production of IL-4, the key marker of Th2 cells was increased.ConclusionThis study suggests that in vitro supplementation with flavonoïds extracted from Artemisia herba alba could have potential immuno-modulatory effects characterised by a down-regulation and up-regulation of Th1 and Th2 cytokines, respectively. Moreover, flavonoïds may prevent nitric oxide induced damages.

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Production des cytokines Th1/Th2 et du monoxyde d′azote au cours de l’uvéite « Behçet » et de l’uvéite « idiopathique »

Cited by 42 publications

References 25 publications

Serum Profiles of Cytokines in Behcet’s Disease

Serum Profiles of Cytokines in Behcet’s Disease

Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet’s Disease Risk in Western Algeria

Ex vivo effects of flavonoïds extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behçet's disease

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