Production and therapeutic use of astaxanthin in the nanotechnology era

Abdelazim, Karim; Ghit, Amr; Assal, Dina; Dorra, Neamat; Noby, Nehad; Khattab, Sherine N.; El Feky, Shaymaa Essam; Hussein, Ahmed

doi:10.1007/s43440-023-00488-y

Cited by 6 publications

(3 citation statements)

References 116 publications

(156 reference statements)

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“…Adverse events were generally mild, with the most commonly reported being gastrointestinal upset. These findings align with the established safety profile of astaxanthin, with previous studies reporting minimal adverse effects [19]. The slightly higher incidence of adverse events in the experimental group warrants consideration.…”

Section: Discussionsupporting

confidence: 88%

Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial

Perumal,

Patil,

Karobari

2024

Cureus

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Background: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder characterized by progressive fibrosis of the oral mucosa, leading to restricted mouth opening and discomfort. This study investigates the efficacy and safety of astaxanthin, a potent antioxidant and anti-inflammatory carotenoid, in the comprehensive management of OSMF.Methods: A randomized, double-blind, placebo-controlled trial was conducted with 68 eligible participants diagnosed with OSMF. Participants were randomly assigned to the experimental group (astaxanthin capsules, 5 mg twice daily) or the control group (placebo capsules) for 12 weeks. Primary outcomes included changes in mouth opening and burning sensation assessed by Visual Analog Scale (VAS). Adverse events were monitored to evaluate safety.Results: The experimental group demonstrated a statistically significant improvement in mouth opening compared to the control group over the 12-week intervention (p < 0.001). Additionally, the experimental group reported a significant reduction in burning sensation, as indicated by VAS scores (p < 0.001). Adverse events were generally mild and comparable between groups. Conclusion:This study suggests that astaxanthin may have a positive impact on mouth opening and burning sensation in individuals with OSMF. The safety profile observed supports the feasibility of astaxanthin as a potential therapeutic adjunct in OSMF management. Further research with larger sample sizes and extended follow-up periods is warranted to validate these findings.

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Section: Discussionsupporting

confidence: 88%

Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial

Perumal,

Patil,

Karobari

2024

Cureus

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“…For example, astaxanthin is a pigment derived from microorganisms that has the ability to scavenge oxygen free radicals and has always had an effect on skin aging. Solid lipid nanoparticles containing astaxanthin, nanostructured lipid carriers, and polymer nanospheres are often considered new materials that have good anti-skin-aging effects, and this application has broad application prospects [94].…”

Section: Fungusmentioning

confidence: 99%

Research Progress on Bioactive Factors against Skin Aging

He,

Gao,

Guo

et al. 2024

IJMS

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The relentless pursuit of effective strategies against skin aging has led to significant interest in the role of bioactive factors, particularly secondary metabolites from natural sources. The purpose of this study is to meticulously explore and summarize the recent advancements in understanding and utilization of bioactive factors against skin aging, with a focus on their sources, mechanisms of action, and therapeutic potential. Skin, the largest organ of the body, directly interacts with the external environment, making it susceptible to aging influenced by factors such as UV radiation, pollution, and oxidative stress. Among various interventions, bioactive factors, including peptides, amino acids, and secondary metabolites, have shown promising anti-aging effects by modulating the biological pathways associated with skin integrity and youthfulness. This article provides a comprehensive overview of these bioactive compounds, emphasizing collagen peptides, antioxidants, and herbal extracts, and discusses their effectiveness in promoting collagen synthesis, enhancing skin barrier function, and mitigating the visible signs of aging. By presenting a synthesis of the current research, this study aims to highlight the therapeutic potential of these bioactive factors in developing innovative anti-aging skin care solutions, thereby contributing to the broader field of dermatological research and offering new perspectives for future studies. Our findings underscore the importance of the continued exploration of bioactive compounds for their potential to revolutionize anti-aging skin care and improve skin health and aesthetics.

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“…Many experiments have demonstrated the inhibitory effect of AST on UVR-induced cytotoxicity and epidermal keratinocyte cell death [216,217,245,246,[249][250][251][252].…”

Section: Astaxanthinmentioning

confidence: 99%

Skin Protection by Carotenoid Pigments

Flieger,

Raszewska-Famielec,

Radzikowska-Büchner

et al. 2024

IJMS

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Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, and photosynthetic pigments, can protect the skin against the effects of radiation, acting not only as photoprotectors like natural filters but as antioxidant and anti-inflammatory remedies, alleviating the effects of photodamage to the skin. Plant-based formulations are gaining popularity as an attractive alternative to synthetic filters. Over the past 20 years, a large number of studies have been published to assess the photoprotective effects of natural plant products, primarily through their antioxidant, antimutagenic, and anti-immunosuppressive activities. This review selects the most important data on skin photodamage and photoprotective efficacy of selected plant carotenoid representatives from in vivo studies on animal models and humans, as well as in vitro experiments performed on fibroblast and keratinocyte cell lines. Recent research on carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, and micelles is reviewed. The focus was on collecting those nanomaterials that serve to improve the bioavailability and stability of carotenoids as natural antioxidants with photoprotective activity.

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Production and therapeutic use of astaxanthin in the nanotechnology era

Cited by 6 publications

References 116 publications

Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial

Efficacy and Safety of Astaxanthin in the Management of Oral Submucous Fibrosis: A Preliminary Randomized Controlled Trial

Research Progress on Bioactive Factors against Skin Aging

Skin Protection by Carotenoid Pigments

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