Research Progress on Bioactive Factors against Skin Aging

Abstract

The relentless pursuit of effective strategies against skin aging has led to significant interest in the role of bioactive factors, particularly secondary metabolites from natural sources. The purpose of this study is to meticulously explore and summarize the recent advancements in understanding and utilization of bioactive factors against skin aging, with a focus on their sources, mechanisms of action, and therapeutic potential. Skin, the largest organ of the body, directly interacts with the external environment, making it susceptible to aging influenced by factors such as UV radiation, pollution, and oxidative stress. Among various interventions, bioactive factors, including peptides, amino acids, and secondary metabolites, have shown promising anti-aging effects by modulating the biological pathways associated with skin integrity and youthfulness. This article provides a comprehensive overview of these bioactive compounds, emphasizing collagen peptides, antioxidants, and herbal extracts, and discusses their effectiveness in promoting collagen synthesis, enhancing skin barrier function, and mitigating the visible signs of aging. By presenting a synthesis of the current research, this study aims to highlight the therapeutic potential of these bioactive factors in developing innovative anti-aging skin care solutions, thereby contributing to the broader field of dermatological research and offering new perspectives for future studies. Our findings underscore the importance of the continued exploration of bioactive compounds for their potential to revolutionize anti-aging skin care and improve skin health and aesthetics.

Research Progress in Skin Aging and Immunity

“…Some microbial, cellular, or protein products are claimed to be able to reprogram our immune system. In addition to these, lots of natural products including plant extracts or components have wide activities in terms of immune rehabilitation [120].…”

“…Lots of cellular, microbial, protein-based, and natural products have shown significant anti-inflammatory activity. So, it should be not difficult for us to find some effective anti-aging products for skin [120,124]. The immune regulation strategies for skin aging and immune activation are summarized in Figure 2.…”