Production and Roles of IL-6, IL-10, and IL-13 in B-Lymphocyte Malignancies and in B-Lymphocyte Hyperactivity of HIV Infection and Autoimmunity

Émilie, Dominique; Zou, Weiping; Fior, R; Llórente, Luis; Durandy, Anne; Crevon, Marie‐Claude; Maillot, M C; Durand-Gasselin, Ingrid; Raphael, M.; Galamaud, Pierre

doi:10.1006/meth.1996.0397

Cited by 33 publications

(26 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…315,316 The cytokine growth factors interleukin-6 (IL-6) and interleukin-10 (IL-10), which are involved in inflammatory response, may be important for the pathogenesis of multiple myeloma. [317][318][319][320][321] These interleukins may stimulate myeloma cell survival and proliferation of myeloma cell lines. 317,318,[320][321][322] Zheng et al…”

Section: Genetic Variationmentioning

confidence: 99%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

View full text Add to dashboard Cite

Multiple myeloma, a neoplasm of plasma cells, accounts for 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no established lifestyle, occupational or environmental risk factors. Although several factors have been implicated as potentially etiologic, findings are inconsistent. We reviewed epidemiologic studies that evaluated lifestyle, dietary, occupational and environmental factors; immune function, family history and genetic factors; and the hypothesized precursor, monoclonal gammopathies of undetermined significance (MGUS). Because multiple myeloma is an uncommon disease, etiologic assessments can be difficult because of small numbers of cases in occupational cohort studies, and few subjects reporting exposure to specific agents in case-control studies. Elevated risks have been reported consistently among persons with a positive family history of LHC. A few studies have reported a relationship between obesity and multiple myeloma, and this may be a promising area of research. Factors underlying higher incidence rates of multiple myeloma in African Americans are not understood. The progression from MGUS to multiple myeloma has been reported in several studies; however, there are no established risk factors for MGUS. To improve our understanding of the causes of multiple myeloma, future research efforts should seek the causes of MGUS. More research is also needed on the genetic factors of multiple myeloma, given the strong familial clustering of the disease. ' 2007 Wiley-Liss, Inc.Key words: multiple myeloma; epidemiology Multiple myeloma is a malignancy of plasma cells that results in an overproduction of light and heavy chain monoclonal immunoglobulins. The specific immunoglobulin secreted by the malignant cell is the M-protein, named in reference to its monoclonal characteristics. It is found in the serum and/or urine of persons affected with multiple myeloma.

show abstract

Section: Genetic Variationmentioning

confidence: 99%

Multiple myeloma: A review of the epidemiologic literature

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Other cytokines of potential importance include (IL)-6 and IL-10 and TNF-a. IL-10 mediates autoantibody production and may function as an autocrine growth factor in B-cell lymphomas (152). Apart from being a key inflammatory mediator in RA and other inflammatory diseases, TNF is also a growth factor for lymphoma.…”

Section: Common Mechanisms Of Lymphomagenesismentioning

confidence: 99%

Malignant Lymphomas in Autoimmunity and Inflammation: A Review of Risks, Risk Factors, and Lymphoma Characteristics

Smedby

Baecklund

Askling

2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

218

146

View full text Add to dashboard Cite

Certain autoimmune and chronic inflammatory conditions, such as Sjögren's syndrome and rheumatoid arthritis (RA), have consistently been associated with an increased risk of malignant lymphomas, but it is unclear whether elevated lymphoma risk is a phenomenon that accompanies inflammatory conditions in general. Likewise, it is debated whether the increased risk identified in association with some disorders pertains equally to all individuals or whether it varies among groups of patients with different phenotypic or treatment-related characteristics. It is similarly unclear to what extent the increased lymphoma occurrence is mediated through specific lymphoma subtypes. This update reviews the many findings on risks, risk levels, and lymphoma characteristics that have been presented recently in relation to a broad range of chronic inflammatory, including autoimmune, conditions. Recent results clearly indicate an association between severity of chronic inflammation and lymphoma risk in RA and Sjögren's syndrome. Thus, the average risk of lymphoma in RA may be composed of a markedly increased risk in those with most severe disease and little or no increase in those with mild or moderate disease. The roles of immunosuppressive therapy and EBV infection seem to be limited. Furthermore, RA, Sjögren's syndrome, systemic lupus erythematosus, and possibly celiac disease may share an association with risk of diffuse large B-cell lymphoma, in addition to well-established links of Sjögren's syndrome with risk of mucosa-associated lymphoid tissue lymphoma and of celiac disease with risk of small intestinal lymphoma. However, there is also obvious heterogeneity in risk and risk mediators among different inflammatory diseases. (Cancer Epidemiol Biomarkers Prev 2006;15(11):2069–77)

show abstract

“…14,15 In AIDS-associated Burkitt lymphoma (BL), which accounts for 30 per cent of all cases of AIDSassociated lymphomas, the molecular lesions involve activation of myelocytomatosis cancer oncogene (cMYC) and inactivation of tumour suppressor protein (P53). …”

Section: Treatment Was Multidisciplinary and Included Orthopaedics Nmentioning

confidence: 99%

Osseous manifestations of non-Hodgkin's lymphoma in Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS)

Magagula

Rasool

Ramdial³

et al. 2015

SA orthop. j.

View full text Add to dashboard Cite

show abstract

Production and Roles of IL-6, IL-10, and IL-13 in B-Lymphocyte Malignancies and in B-Lymphocyte Hyperactivity of HIV Infection and Autoimmunity

Cited by 33 publications

References 0 publications

Multiple myeloma: A review of the epidemiologic literature

Multiple myeloma: A review of the epidemiologic literature

Malignant Lymphomas in Autoimmunity and Inflammation: A Review of Risks, Risk Factors, and Lymphoma Characteristics

Osseous manifestations of non-Hodgkin's lymphoma in Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS)

Contact Info

Product

Resources

About