“…For example, Hoang Thi and others (14) showed the dissolution kinetics and (instrumentally measured) “taste” of paracetamol (acetominophen) was reduced by spray drying with caseinate. In a similar study the sensory bitterness of casein hydrosylates was reduced by spray drying with soy proteins (85). Interestingly though these workers assessed the taste of the powder directly and it seems likely in a liquid medium the particles would dissolve and the benefits would be lost.…”
Section: Delivery Systems To Mask Bitter Tastementioning
Many drugs and desirable phytochemicals are bitter, and bitter tastes are aversive. Food and pharmaceutical manufacturers share a common need for bitterness-masking strategies that allow them to deliver useful quantities of the active compounds in an acceptable form and in this review we compare and contrast the challenges and approaches by researchers in both fields. We focus on physical approaches, i.e., micro- or nano-structures to bind bitter compounds in the mouth, yet break down to allow release after they are swallowed. In all of these methods, the assumption is the degree of bitterness suppression depends on the concentration of bitterant in the saliva and hence the proportion that is bound. Surprisingly, this hypothesis has only rarely been fully tested using a combination of adequate human sensory trials and measurements of binding. This is especially true in pharmaceutical systems, perhaps due to the greater experimental challenges in sensory analysis of drugs.
“…For example, Hoang Thi and others (14) showed the dissolution kinetics and (instrumentally measured) “taste” of paracetamol (acetominophen) was reduced by spray drying with caseinate. In a similar study the sensory bitterness of casein hydrosylates was reduced by spray drying with soy proteins (85). Interestingly though these workers assessed the taste of the powder directly and it seems likely in a liquid medium the particles would dissolve and the benefits would be lost.…”
Section: Delivery Systems To Mask Bitter Tastementioning
Many drugs and desirable phytochemicals are bitter, and bitter tastes are aversive. Food and pharmaceutical manufacturers share a common need for bitterness-masking strategies that allow them to deliver useful quantities of the active compounds in an acceptable form and in this review we compare and contrast the challenges and approaches by researchers in both fields. We focus on physical approaches, i.e., micro- or nano-structures to bind bitter compounds in the mouth, yet break down to allow release after they are swallowed. In all of these methods, the assumption is the degree of bitterness suppression depends on the concentration of bitterant in the saliva and hence the proportion that is bound. Surprisingly, this hypothesis has only rarely been fully tested using a combination of adequate human sensory trials and measurements of binding. This is especially true in pharmaceutical systems, perhaps due to the greater experimental challenges in sensory analysis of drugs.
“…Hence, SPI was often firstly dissolved in pH 8.0 to obtain the maximum solubility (Mendanha et al, 2009;Molina Ortiz et al, 2009). To avoid the possible effect of extra ions added for subsequent pH adjustment, ultrasonic treatment was used to increase the solubility of SPI in distilled water.…”
Section: Effect Of Ph On Complex Coacervationmentioning
“…There has been growing interest within the pharmaceutical, cosmetic, and food industries in the application of biopolymers (e.g., proteins and polysaccharides) to encapsulate, protect, and release various bioactive lipophilic components, aromas, proteins, natural food additives, etc (Chen, Remondetto, & Subirade, 2006;Molina Ortiz et al, 2009;Nori et al, 2011). The potential application of these biopolymers depends greatly on the repulsive and attractive interactions that may exist among them, which would cause different phenomena, from biopolymer incompatibility to complex formation (de Kruif, Weinbreck, & de Vries, 2004).…”
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