The partnership program conducted by broiler farmers using a limited capital is continuously developing due to the beneficial profitability. However, in a certain period, broiler farmers do not gain an expected profit (sometimes suffering loss) as various input and output factors, mortality and land ownership occur. The research, then, aims to comprehend the profitability of the broiler business and analyze determining factors of broiler farmer’s profitability, utilizing the open-house cage system under the partnership program. Technically, the sampling method of the respondent was purposively determined, and the data collecting technique was through interview, observation, and recording on 30 farmers existing in Tomohon, North Sulawesi. In detail, all collected data were economically and descriptively analyzed, and the multiple-regression analysis employed Eviews 11 program. As a result, the finding of this research shows that the value of R/C was 1.12, and variables having positive and significant meaning to profit were demonstrated by a total of feeds, and the dummy of the proprietorship; while, the variable of mortality had negative and significant meaning on the profit of broiler farmer. Further, the profitability gained by broiler farmers in the Province of North Sulawesi can be improved by increasing the total of feeds, decreasing mortality, and having broiler businesses in their private land/cages independently.