Production and NMR Characterization of Hyperpolarized ^107,109Ag Complexes

Abstract

Both isotopes of silver [107Ag and 109Ag] were simultaneously polarized by dynamic nuclear polarization (DNP) Large liquid-state NMR enhancements were achieved allowing the Ag NMR characterization of the complexes in mM concentration range. Since both isotopes have long T1, the hyperpolarized NMR signal of one isotope could still be observed even after the magnetization of the other isotope had already been destroyed by rf excitation pulses.

Construction and 13C hyperpolarization efficiency of a 180 GHz dissolution dynamic nuclear polarization system

“…In particular, the use of hyperpolarized 13 C biomolecules such as 13 C pyruvate allows NMR and MRI studies that can track the metabolism in cells in vitro and tissues in vivo in real-time with unprecedented sensitivity and superb specificity. [7][8][9][10][11][12][13] In addition to 13 C spins, the liquid-state NMR sensitivity of other low-γ nuclei with relatively long T 1 such as 15 N, [14] 6 Li, [15] 89 Y, [16,17] and 107,109 Ag [18] have also been shown to be greatly enhanced by dissolution DNP. With this capability, hyperpolarized 13 C magnetic resonance in particular offers a promising diagnostic molecular imaging method in which endogenous metabolic probes can be used to track metabolism of normal and diseased tissues such as cancer, without the drawbacks of other imaging methods such as the radioactivity in positron emission tomography (PET) or the large background signal in conventional in vivo proton NMR and MRI.…”

Crystal structure of bis(1,3-bis(diphenylphosphino)propane-κ 2 P,P′)silver(I) trifluorosulfonate–methanol (1:0.5), [Ag(C27H26P2)]SO3CF3⋅0.5CH3OH

“…Hence, it is used as a kind chelating or bridging ligand in self-assembly process. The title complex has been already mentioned [7], however, the crystal structure has not been reported so far. The structure of the title complex is similar to the complex [Ag(dppp)]NO 3 [8].…”

CHAPTER 9. Hyperpolarization: Concepts, Techniques and Applications

“…Dissolution DNP was developed within Amersham Health Research and Development AB, a company that was later purchased by GE Healthcare. 41 The technique has been applied to hyperpolarize 1 H, 6 Li, 13 C, 15 N, 89 Y and both 107 Ag and 109 Ag, 34,[41][42][43][44][45][46][47] and the liquid-state nuclear polarizations can be typically enhanced by 3-4 orders of magnitude compared to the room-temperature thermal polarizations obtained in standard fields (3-14 T).…”

“…For instance, Lumata et al demonstrated that silver complexes, which have been shown to have effective antimicrobial and anticancer properties, can be readily detected after having been hyperpolarized. 44 It is also possible to measure how long the drug stays in blood and how efficiently it is metabolized by the organism. Since this time period is in most cases much longer than the lifetime of the hyperpolarized state, it has been proposed to perform such measurements in vitro by hyperpolarizing blood samples.…”