Production and Metabolism of Triglyceride-Rich Lipoproteins in Both the Normal and Diabetic States

Pirillo, Angela; Norata, Giuseppe Danilo; Catapano, Alberico L.

doi:10.1007/978-1-4614-7554-5_6

Cited by 4 publications

(6 citation statements)

References 130 publications

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“…The C-terminus of apoB100 produced in the liver contains the domain recognized by low-density lipoprotein receptor (LDLR) and thus mediates the high-affinity hepatic clearance of normal VLDL from plasma. The truncated form of intestinal apoB48 of chylomicrons, which lacks the C-terminus of apoB100, does not bind the LDLR 14 .…”

Section: Postprandial Lipemiamentioning

confidence: 99%

“…Insulin tightly regulates VLDL production: under fasting conditions, hepatic VLDL production is induced, while the increase of postprandial insulin reduces VLDL production 14 . The C-terminus of apoB100 produced in the liver contains the domain recognized by low-density lipoprotein receptor (LDLR) and thus mediates the high-affinity hepatic clearance of normal VLDL from plasma.…”

Section: Postprandial Lipemiamentioning

confidence: 99%

“…ApoB is synthesized in coordination with the activity of the microsomal triglyceride transfer protein (MTP) that, in the presence of lipids, quickly lipidates nascent apoB, resulting in a nascent apoB-containing particle 14 ; next, the addition of neutral lipids increases the size of these particles that are then secreted into circulation (VLDLs) or in the lymphatic system (CMs). Insulin tightly regulates VLDL production: under fasting conditions, hepatic VLDL production is induced, while the increase of postprandial insulin reduces VLDL production 14 .…”

Section: Postprandial Lipemiamentioning

confidence: 99%

“…Plasma lipoproteins undergo a series of changes in their composition and concentration during the postprandial period; therefore lipemic response is complex and is known to be influenced by many environmental and genetic factors 14 . Many studies were carried out during the past few years and examined single-nucleotide polymorphisms (SNPs) at individual genes or the combination of alleles that tend to be transmitted in conjunction (haplotypes), for their relation with specific traits during postprandial lipemia 69 .…”

Section: Genetic Factorsmentioning

confidence: 99%

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Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

Self Cite

102

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High levels of fasting circulating triglycerides (TG) represent an independent risk factor for cardiovascular disease. In western countries, however, people spend most time in postprandial conditions, with continuous fluctuation of lipemia due to increased levels of TG-rich lipoproteins (TRLs), including chylomicrons (CM), very low density lipoproteins (VLDL), and their remnants. Several factors contribute to postprandial lipid metabolism, including dietary, physiological, pathological and genetic factors. The presence of coronary heart disease, type 2 diabetes, insulin resistance and obesity is associated with higher postprandial TG levels compared with healthy conditions; this association is present also in subjects with normal fasting TG levels. Increasing evidence indicates that impaired metabolism of postprandial lipoproteins contributes to the pathogenesis of coronary artery disease, suggesting that lifestyle modifications as well as pharmacological approaches aimed at reducing postprandial TG levels might help to decrease the cardiovascular risk.

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Section: Postprandial Lipemiamentioning

confidence: 99%

Section: Postprandial Lipemiamentioning

confidence: 99%

Section: Postprandial Lipemiamentioning

confidence: 99%

Section: Genetic Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Postprandial lipemia as a cardiometabolic risk factor

Pirillo

Norata

Catapano

2014

Current Medical Research and Opinion

Self Cite

102

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“…The plasma concentration, structure and dynamic composition of these lipoproteins is of immense biological importance as their dysregulation is a major causal factor for atherosclerotic cardiovascular disease (ASCVD) 7;8 . Hypertriglyceridemia, caused due to an increase in TRLs in plasma has been shown to contribute to intimal cholesterol deposition, activation and enhancement of pro-inflammatory and pro-coagulant pathways as well as concomitant changes in high density lipoprotein (HDL) 9 . These changes are associated with a substantially increased long term total mortality and risk for cardiovascular events 8;10 .…”

Section: Introductionmentioning

confidence: 99%

Solvation Dynamics of a Single Triglyceride as a Function of its Chain Length

Sacher

2022

Preprint

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Triglycerides (TG) are transported packaged inside lypophillic particles. Several lipid exchange/transfer proteins interact with these lipoproteins and facilitate lipid exchange amongst lipoproteins, to maintain a constant flux in RCT. During this process, these neutral lipids are inadvertently exposed to the bulk water. Previous studies have elucidated the behavior of triglycerides in the bulk (on the surface of bilayer or inside a lipid droplet). However, isolated TGs during lipid exchange behave differently than when in bulk, due to an increased exposure to water. We studied the solvation dynamics of a single TG in a polar (water) and a non-polar (cyclohexane) medium to elucidate its solvated structure while drawing parallels with its structural organization in bulk (lipid droplet). We also examine the role of acyl chain length and its contribution to the free energy of solvation. Finally, we have established the predominant conformation of TG in water and cyclohexane and discuss the thermodynamics for such a preference.

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