Production and evaluation of biosynthesized cellulose tubes as promising nerve guides for spinal cord injury treatment

Stumpf, Taisa Regina; Tang, Linda; Kirkwood, Kathlyn M.; Yang, Xiuying; Zhang, Jingchang; Cao, Xudong

doi:10.1002/jbm.a.36909

Cited by 11 publications

(8 citation statements)

References 59 publications

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“…167,168 This method involves moving bamboo or glass templates wetted with culture media into and out of a culture reservoir. The tubes are then manually inverted so that 28,66,102,138,160,166,180,181,183,184 Young's modulus (MPa) 10.5 5 0.06−3.2 36,135,179 0.25−6 43,47,66,102,138,160,166,181 Elongation at Break (%) 50−65 135 20−50 43,66,138,160,166,181 Suture Retention (N)…”

Section: Cyclical Fermentation Methods Of Producing Tubular Bncmentioning

confidence: 99%

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

et al. 2023

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Understanding the interaction between biomaterials and blood is critical in the design of novel biomaterials for use in biomedical applications. Depending on the application, biomaterials can be designed to promote hemostasis, slow or stop bleeding in an internal or external wound, or prevent thrombosis for use in permanent or temporary medical implants. Bacterial nanocellulose (BNC) is a natural, biocompatible biopolymer that has recently gained interest for its potential use in blood-contacting biomedical applications (e.g., artificial vascular grafts), due to its high porosity, shapeability, and tissue-like properties. To promote hemostasis, BNC has been modified through oxidation or functionalization with various peptides, proteins, polysaccharides, and minerals that interact with the coagulation cascade. For use as an artificial vascular graft or to promote vascularization, BNC has been extensively researched, with studies investigating different modification techniques to enhance endothelialization such as functionalizing with adhesion peptides or extracellular matrix (ECM) proteins as well as tuning the structural properties of BNC such as surface roughness, pore size, and fiber size. While BNC inherently exhibits comparable mechanical characteristics to endogenous blood vessels, these mechanical properties can be enhanced through chemical functionalization or through altering the fabrication method. In this review, we provide a comprehensive overview of the various modification techniques that have been implemented to enhance the suitability of BNC for blood-contacting biomedical applications and different testing techniques that can be applied to evaluate their performance. Initially, we focused on the modification techniques that have been applied to BNC for hemostatic applications. Subsequently, we outline the different methods used for the production of BNC-based artificial vascular grafts and to generate vasculature in tissue engineered constructs. This sequential organization enables a clear and concise discussion of the various modifications of BNC for different blood-contacting biomedical applications and highlights the diverse and versatile nature of BNC as a natural biomaterial.

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Section: Cyclical Fermentation Methods Of Producing Tubular Bncmentioning

confidence: 99%

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

et al. 2023

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“…Neurite stimulation was provided by NGF-loaded BCTs. 80 BCTs that had been loaded with NGF had good mechanical characteristics; in particular, BCTs that had been cultured for 22 days (BCTs22) had a Young's Modulus that was comparable to that of the spinal cord. NGF also remained bioactive on PC12 cells following BC tube removal.…”

Section: Cellulose (Cl) Based Polysaccharide Drug Delivery Systems Fo...mentioning

confidence: 99%

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Kumar,

Malviya,

Sundram

2024

MedComm – Biomaterials and Applications

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The management of peripheral nerve injuries is an important concern due to the their incidence of nerve lesions and inappropriate regeneration that follows severe injuries, which ultimately reduces the lives of patients with this condition. Different strategies have been investigated to repair severe nerve injuries with the improvement of motor and sensory regeneration. Although autograft remains the gold standard technique, an emerging number of research articles concerning nerve conduit use have been reported in the last few years. Nerve conduits aim to overcome autograft disadvantages, but they satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural‐based biomaterials have great potential to be used to produce nerve guides. Although they have many characteristics with synthetic biomaterials, natural‐based biomaterials are preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review highlights the recent progress in the development of natural‐based biomaterials and their derivatives for the management of peripheral nerve injuries.

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“…BCTs22 enabled an NGF-controlled release for 7 days, with an initial (8 h) burst release, due to the release of NGF molecules from the outer tube surface. Furthermore, NGF maintained its bioactivity on PC12 cells after release from BC tubes [ 81 ].…”

Section: Cellulose (Cl)mentioning

confidence: 99%

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

et al. 2023

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Neurological disorders affecting both CNS and PNS still represent one of the most critical and challenging pathologies, therefore many researchers have been focusing on this field in recent decades. Spinal cord injury (SCI) and peripheral nerve injury (PNI) are severely disabling diseases leading to dramatic and, in most cases, irreversible sensory, motor, and autonomic impairments. The challenging pathophysiologic consequences involved in SCI and PNI are demanding the development of more effective therapeutic strategies since, as yet, a therapeutic strategy that can effectively lead to a complete recovery from such pathologies is not available. Drug delivery systems (DDSs) based on polysaccharides have been receiving more and more attention for a wide range of applications, due to their outstanding physical-chemical properties. This review aims at providing an overview of the most studied polysaccharides used for the development of DDSs intended for the repair and regeneration of a damaged nervous system, with particular attention to spinal cord and peripheral nerve injury treatments. In particular, DDSs based on chitosan and their association with alginate, dextran, agarose, cellulose, and gellan were thoroughly revised.

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Production and evaluation of biosynthesized cellulose tubes as promising nerve guides for spinal cord injury treatment

Cited by 11 publications

References 59 publications

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective

Current Status of Polysaccharides-Based Drug Delivery Systems for Nervous Tissue Injuries Repair

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