2023
DOI: 10.1021/acsmaterialsau.3c00021
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Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

Abstract: Understanding the interaction between biomaterials and blood is critical in the design of novel biomaterials for use in biomedical applications. Depending on the application, biomaterials can be designed to promote hemostasis, slow or stop bleeding in an internal or external wound, or prevent thrombosis for use in permanent or temporary medical implants. Bacterial nanocellulose (BNC) is a natural, biocompatible biopolymer that has recently gained interest for its potential use in blood-contacting biomedical ap… Show more

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Cited by 9 publications
(5 citation statements)
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References 177 publications
(618 reference statements)
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“…Many studies have been published on the chemical modification of nanofibers. Nanofibers have high mechanical strength due to their crystallinity, and if molecules that inhibit thrombus formation, such as heparin, can be immobilized using a small number of hydroxyl groups that do not affect the crystallinity [32], the potential applications in relation to the removal of blood uremic toxins by ACEG will be further enhanced.…”
Section: Evaluation Of Adsorption Capacity Of Uremic Toxins In the Pr...mentioning
confidence: 99%
“…Many studies have been published on the chemical modification of nanofibers. Nanofibers have high mechanical strength due to their crystallinity, and if molecules that inhibit thrombus formation, such as heparin, can be immobilized using a small number of hydroxyl groups that do not affect the crystallinity [32], the potential applications in relation to the removal of blood uremic toxins by ACEG will be further enhanced.…”
Section: Evaluation Of Adsorption Capacity Of Uremic Toxins In the Pr...mentioning
confidence: 99%
“…Bacterial nanocellulose (BNC), with superior thermostability, mechanical strength, and crystallinity, , represents a promising biomaterial for diverse applications spanning from biomedicine to manufacturing of cosmetics, food, and electronic products. However, the low productivity of BNC remains a key barrier to its mass production, and engineering of BNC biosynthesis is currently restricted by our poor knowledge of the influential factors.…”
Section: Introductionmentioning
confidence: 99%
“…BNC can also be easily modified and functionalized through genetic engineering and/or synthetic biology approaches. BNC materials are applied in tissue engineering applications such as regenerative medicine, where biomimetics are used as a strategy to develop scaffolds that resemble native tissues and activate self-cell regeneration. , BNC materials have excellent biocompatibility that suit them for biomedical applications such as antimicrobial treatment, wound healing, , and blood vessel replacements . Moreover, the 3D-bioink printing field utilized BNC materials to form double cross-lined biomaterial films for medical field applications such as cell proliferation, cartilage regeneration, tissue repairs, and hemostatic applications . However, the BNC biofilm production process has a significant hurdle arising from the complex interplay of bacterial growth conditions and shifts in bacterial behavior during the production phase.…”
Section: Introductionmentioning
confidence: 99%
“… 19 Moreover, the 3D-bioink printing field utilized BNC materials to form double cross-lined biomaterial films for medical field applications such as cell proliferation, 20 cartilage regeneration, 21 tissue repairs, 22 and hemostatic applications. 23 However, the BNC biofilm production process has a significant hurdle arising from the complex interplay of bacterial growth conditions and shifts in bacterial behavior during the production phase. This intricacy often renders the conversion of these BNC biofilms into a reproducible, practical, and useable form a challenging endeavor.…”
Section: Introductionmentioning
confidence: 99%