“…Active packaging systems are designed to promote interactions between the packaging itself, the food, and the internal environment. In this framework, natural extracts represent a valuable source of bioactive compounds, such as polyphenols, characterized by well documented in vitro and in vivo antioxidant and antimicrobial properties [ 3 , 4 ] and they can be incorporated in or coated on food packaging materials to prevent microbial development, reduce lipid oxidation, and thereby extend the shelf-life of packaged foods [ 4 , 5 , 6 ]. Natural extracts can be obtained from different natural sources, such as fruits (e.g., grape and pomegranate), herbs and spices (e.g., tea, rosemary, oregano, and cinnamon), or, in a more sustainable view, from plant by-products, such as grapefruit seeds, grape pomace, orange peels, green tea and olive leaves, which are valued for their high functionality and/or bioactivity [ 1 , 7 , 8 ].…”