Production and antimicrobial activity of trans-resveratrol, trans-arachidin-1 and trans-arachidin-3 from elicited peanut hairy root cultures in shake flasks compared with bioreactors

Eungsuwan, Nichanan; Chayjarung, Phadtraphorn; Pankam, Jintana; Pilaisangsuree, Vijakhana; Wongshaya, Pakwuan; Kongbangkerd, Anupan; Sriphannam, Chayaphon; Limmongkon, Apinun

doi:10.1016/j.jbiotec.2020.12.006

Cited by 12 publications

(8 citation statements)

References 35 publications

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“…[ [92][93][94][95] Oil, skin, roots, and leaves. Anti-inflammatory, antioxidant, cardioprotective, and anticancer properties.…”

Section: Ginkgo Biloba and Health Effects 41 Ginkgo Biloba General As...mentioning

confidence: 99%

Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Pagotto,

Santos,

Osman

et al. 2024

Antioxidants

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Alzheimer’s disease (AD) is a stealthy and progressive neurological disorder that is a leading cause of dementia in the global elderly population, imposing a significant burden on both the elderly and society. Currently, the condition is treated with medications that alleviate symptoms. Nonetheless, these drugs may not consistently produce the desired results and can cause serious side effects. Hence, there is a vigorous pursuit of alternative options to enhance the quality of life for patients. Ginkgo biloba (GB), an herb with historical use in traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, and C), polyphenols, organic acids, and flavonoids (quercetin, kaempferol, and isorhamnetin). These compounds are associated with anti-inflammatory, antioxidant, and neuroprotective properties, making them valuable for cognitive health. A systematic search across three databases using specific keywords—GB in AD and dementia—yielded 1702 documents, leading to the selection of 15 clinical trials for synthesis. In eleven studies, GB extract/EGb 761® was shown to improve cognitive function, neuropsychiatric symptoms, and functional abilities in both dementia types. In four studies, however, there were no significant differences between the GB-treated and placebo groups. Significant improvements were observed in scores obtained from the Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), and Neuropsychiatric Inventory (NPI). While the majority of synthesized clinical trials show that Ginkgo biloba has promising potential for the treatment of these conditions, more research is needed to determine optimal dosages, effective delivery methods, and appropriate pharmaceutical formulations. Furthermore, a thorough assessment of adverse effects, exploration of long-term use implications, and investigation into potential drug interactions are critical aspects that must be carefully evaluated in future studies.

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“…[ [92][93][94][95] Oil, skin, roots, and leaves. Anti-inflammatory, antioxidant, cardioprotective, and anticancer properties.…”

Section: Ginkgo Biloba and Health Effects 41 Ginkgo Biloba General As...mentioning

confidence: 99%

Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Pagotto,

Santos,

Osman

et al. 2024

Antioxidants

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“…4800 mg/L of trans -arachidin-3. The roots grown in the bioreactor showed maximum productivity with 20 g/L inoculum, after 48 h treatment [ 199 ].…”

Section: Polyphenolic Antioxidants In Hrsmentioning

confidence: 99%

Hairy Root Cultures as a Source of Polyphenolic Antioxidants: Flavonoids, Stilbenoids and Hydrolyzable Tannins

Malarz

Michalska

Yudina

et al. 2022

Plants

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Due to their chemical properties and biological activity, antioxidants of plant origin have gained interest as valuable components of the human diet, potential food preservatives and additives, ingredients of cosmetics and factors implicated in tolerance mechanisms against environmental stress. Plant polyphenols are the most prominent and extensively studied, albeit not only group of, secondary plant (specialized) metabolites manifesting antioxidative activity. Because of their potential economic importance, the productive and renewable sources of the compounds are desirable. Over thirty years of research on hairy root cultures, as both producers of secondary plant metabolites and experimental systems to investigate plant biosynthetic pathways, brought about several spectacular achievements. The present review focuses on the Rhizobium rhizogenes-transformed roots that either may be efficient sources of plant-derived antioxidants or were used to elucidate some regulatory mechanisms responsible for the enhanced accumulation of antioxidants in plant tissues.

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“…Grain skin (Rossi et al, 2020b) Antihemolytic activity Luteolin Bark (M. Peng et al, 2021) Anti-bacterial Stilbene (trans-arachidine-1 and trans-arachidine-3 Roots (Eungsuwan et al, 2021a) Antioxidant / anti-inflammatory Flavonoids, Stybenes, Anthocyanins Integument, roots and black peanut shells; Leaves; Sprouted grain (Cossetin et al, 2019;Fernandes et al, 2020;Limmongkon et al, 2018Limmongkon et al, , 2019J. Peng et al, 2019b) Differentiation of osteoblasts Concentrated aqueous extract Peanut sprouts (Kim et al, 2019b) Byrsonima verbascifolia Research, Society and Development, v. 11, n. 11, e100111133442, 2022 (CC BY 4.0)…”

Section: Cell Protectionmentioning

confidence: 99%

“…Chemically, phenolic compounds have in their molecular structure a hydroxyl radical (-OH) linked to an aromatic ring (Figure 4). (Eungsuwan et al, 2021a;Fidelisde-Oliveira et al, 2020;Lira et al, 2017).…”

Section: Chemical Composition Of Plants Observed In the Caatingamentioning

confidence: 99%

“…Among the selected articles, the analysis of the compounds of the roots, leaves, seed shoots, and byproducts of peanut processing, such as skin and shell, were the study targets. Among the activities identified are antioxidants and antiinflammatory drugs in a significant way, as well as a display of anti-hemolytic activity, inhibition of prostatic, antibacterial, and anti-adipogenic hyperplasia (Cossetin et al, 2019;Eungsuwan et al, 2021b;Fernandes et al, 2020;Kim et al, 2019a;Limmongkon et al, 2018;J. Peng et al, 2019a;Rossi et al, 2020a).…”

Section: Arachis Hypogaeamentioning

confidence: 99%

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Caatinga: barn of antioxidant and nutraceutical bio-actives

Diniz

Santos²,

Barbosa³

et al. 2022

RSD

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The Caatinga, of Brazilian exclusivity, is compound by adapted plants for the climate-specific conditions present in this region. The natural resources in this phytogeography domain are used for local communities as foods source, regional economics develops, and traditional medicine. Folk medicine is applied as a local tradition through the fraction of the plants, such as roots, leaves, and fruits, to treat inflammation, tumor, metabolic or degenerative diseases. Although the technological pharmaceutical industrial process shows exponential development in benefits for human health, the search for new treatments, naturals, and alternatives linked with the significant consciousness of the populations some knowledge about folk medicine and their natural compounds are not vast. In this way, the present review aimed to realize the systematic research considering 26 species endemics in Caatinga and their most significant biological potential. As a result, it was observed that have more studies with the antioxidative and immunomodulatory activities. The previous knowledge shows the relation between the accumulation of reactive oxygen species (ROS) and the development of different immunological diseases. With this review, we propose to contribute to the biotechnological potential of the Caatinga for science health.

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Production and antimicrobial activity of trans-resveratrol, trans-arachidin-1 and trans-arachidin-3 from elicited peanut hairy root cultures in shake flasks compared with bioreactors

Cited by 12 publications

References 35 publications

Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer’s Dementia: Clinical Trial Systematic Review

Hairy Root Cultures as a Source of Polyphenolic Antioxidants: Flavonoids, Stilbenoids and Hydrolyzable Tannins

Caatinga: barn of antioxidant and nutraceutical bio-actives

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