Product Development Studies on the Tablet Formulation of Ibuprofen to Improve Bioavailability

Abstract

To improve the bioavailability of ibuprofen, a thorough preformulation trial was undertaken. As a part of these studies, particle size of the drug, solubility-pH profile, and pH-partition coefficient profile were studied. The probability of improving solubility by solid dispersion technique was also investigated. The effects of different binding agents and incorporation of various proportions of sodium lauryl sulfate on the release rate of ibuprofen were also studied. The in vitro release profiles of the developed tablets showed superiority over the popular marketed tablets.

Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution

“…In particular, the AUC of drug from solid dispersion was about 9-fold higher than that from ibuprofen powder. Thus, the enhanced oral bioavailability of ibuprofen in the solid dispersion might be contributed by the marked increase in the absorption rate of ibuprofen due to the increased dissolution of drug in the solid dispersion in rats (Ghosh et al, 1998;Li et al, 2008;Newa et al, 2007). However, the Tmax, Kel and T 1/2 values of drug from solid dispersion were not significantly different from those from ibuprofen powder.…”

Preparation and Characterization of Ibuprofen Nanoparticles by using Solvent/ Antisolvent Precipitation

“…In the pharmaceuticals industry, a large numbers of drugs are insoluble or poorly soluble in water and drugs sparingly soluble in water are quite often highly soluble in organic solvents [2]. The bioavailability (the percentage of the drug absorbed compared to its initial dosage) is limited by this insolubility [3][4][5][6]. The drug must first be dissolved in order to be absorbed.…”

Preparation and Evaluation of Ibuprofen Solid Dispersion Systems with Kollidon Particles Using a Pulse Combustion Dryer System

“…14,15) Ibuprofen (IBU) is one of the safest and most potent nonsteroidal anti-inflammatory drugs, being widely used in the market for 30 years. 16) Its low solubility (water, 46.9 mg/ml, 37°C; 29.1 mg/ml, 25°C) leads to a potential bioinequivalence problem. 17) Pignatello et al 18) reported that SDs of IBU were prepared with Eudragit RL100 as carriers using a coevaporative method.…”