Produção de fator de necrose tumoral-alfa e peróxido de hidrogênio na infecção pelo Trypanosoma cruzi em camundongos submetidos ao exercício

Soares, Cristiano Schebeleski; Occhi, Roberta Cristhiany; Carvalho, Luana Gomes Luz de; Moraes, Solange Marta Franzói de; Dalalio, Márcia Machado de Oliveira; Araújo, Silvana Márques de

doi:10.4025/actascihealthsci.v32i1.6757

Cited by 2 publications

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“…The studies which assess the correlation between physical exercise and infection by the T. cruzi have pointed out that aerobic physical training performed before the infection may interfere on the response of the host to the parasite; however, the manner and the extent the such alterations will interfere in the infection course are not well explained yet 3,21 . The data obtained for parasitemia present significant differences and tendency observed in other studies recently carried out 3 , in which the animals which are submitted to physical training and then to infection respond better to the infectious agent.…”

Section: Discussionmentioning

confidence: 99%

Infecção experimental pelo Trypanosoma cruzi em camundongos: influência do exercício físico versus linhagens e sexos

Soares

Franzói-de-Moraes

et al. 2012

Rev Bras Med Esporte

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Background: Chagas disease is an infection caused by Trypanosoma cruzi that affects eight million people in Latin America. One factor linked to the lifestyle that significantly interferes in the response to infection is physical exercise, depending on the kind, intensity and frequency of the activity practiced. Objective: To evaluate the influence of pre-infection chronic moderate aerobic exercise in the development of experimental infection with T. cruzi in mice of two distinct lineages from both sexes. Methods: 30-day old Swiss and BALB/c mice (male and female) were divided into four groups for each strain and sex (total 16) and named as follows: SM (Swiss males), SF (Swiss females) BM (BALB/c mice) and BF (BALB/c mice). The groups were: NT NI (untrained uninfected) T NI (trained not infected); NT I (untrained infected), TI (trained infected). The aerobic exercise pre-moderate chronic infection training was performed with one daily session for eight weeks, five times a week. The inoculum was 1,400 blood trypomastigotes of Y strain of T. cruziintraperitoneally. The peak of parasites, parasitemia total and average measurements of the serum activities of CK and CK-MB were evaluated. Results and Conclusions: The physical training promoted reduction in peak, parasitemia parasites and total average in animals infected with T. cruzi in both strains and sexes. Physical training induced reduction in serum activities of CK and CK-MB in animals infected with T. cruzi of both sexes and from the two strains, except for females in the Swiss CK activity.

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Section: Discussionmentioning

confidence: 99%