Detection of tumor necrosis factor-alpha cytokine from the blood serum of a rat infected with Pb18 by a gold nanohole array-based plasmonic biosensor

Predabon, Sheila Maria; Buzzetti, Paulo Henrique M.; Visentainer, Jeane Eliete Laguila; Radovanovic, Eduardo; Monteiro, Johny P.; Girotto, Emerson M.

doi:10.1117/1.jnp.14.036004

Cited by 7 publications

(4 citation statements)

References 64 publications

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“…This is translated into more compact platforms with easier light-excitation methods that can be multiplexed for multiple cytokine detections. Several works have presented improved sensitivity of the detection of cytokines in complex biological fluids utilizing LSPR nanostructures or EOT nanohole arrays, which include detection of IL-1b, IL-18, TNF, and MMP-3 with LOD in low pg/mL and fg/mL (154)(155)(156)(182)(183)(184). The opportunities offered by these label-free optical biosensors are numerous since these devices can adopt a great variety of bioreceptors besides antibodies, including aptamers (185) and triplex-forming DNA probes (165,185) through different chemistry approaches (166) which can improve the detection of multiple cytokines, as well as enrich the analysis with other genetic and epigenetic biomarkers (167,168).…”

Section: Label Free Biosensingmentioning

confidence: 99%

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

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Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may contribute to chronic inflammation that supports tumor growth in both autocrine and paracrine manners and have been linked to poor cancer outcomes. Such distinct sets of cytokines from the tumor microenvironment can be detected in the circulation and are thus potentially useful as biomarkers to detect cancers, predict disease outcomes and manage therapeutic choices. Indeed, analyses of circulating cytokines in combination with cancer-specific biomarkers have been proposed to simplify and improve cancer detection and prognosis, especially from minimally-invasive liquid biopsies, such as blood. Additionally, the cytokine signaling signatures of the peripheral immune cells, even from patients with localized tumors, are recently found altered in cancer, and may also prove applicable as cancer biomarkers. Here we review cytokines induced by the tumor microenvironment, their roles in various stages of cancer development, and their potential use in diagnostics and prognostics. We further discuss the established and emerging diagnostic approaches that can be used to detect cancers from liquid biopsies, and additionally the technological advancement required for their use in clinical settings.

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Section: Label Free Biosensingmentioning

confidence: 99%

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

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“…TNF-α is an inflammation-related protein, which plays an important role in disease diagnosis and prediction. Monteiro et al used a gold nanohole array by transmitted light intensity monitoring to achieve a sensitivity of 4000–5300 IU/RIU and a LOD of 17 pg/mL [ 89 ]. Aluminum has an advantage over the classic noble metal induction process because of its natural abundances, low cost, ease of processing and large-scale manufacturing, and ease of processing with a range of technologies, including complementary metal oxide semiconductor process.…”

Section: Tumor Marker Screening Based On Plasmonic Metasurfacesmentioning

confidence: 99%

Plasmonic Metasurfaces for Medical Diagnosis Applications: A Review

Wang

Chen

Khan

et al. 2021

Sensors

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Plasmonic metasurfaces have been widely used in biosensing to improve the interaction between light and biomolecules through the effects of near-field confinement. When paired with biofunctionalization, plasmonic metasurface sensing is considered as a viable strategy for improving biomarker detection technologies. In this review, we enumerate the fundamental mechanism of plasmonic metasurfaces sensing and present their detection in human tumors and COVID-19. The advantages of rapid sampling, streamlined processes, high sensitivity, and easy accessibility are highlighted compared with traditional detection techniques. This review is looking forward to assisting scientists in advancing research and developing a new generation of multifunctional biosensors.

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“…Experimental setup (Fig. S2) to monitor the transmitted light intensity through the arrays by image acquisition using a charge-coupled device (CCD) camera was already reported by our group and it is shown in the supplementary material [25,26]. The 2x5-Y device was combined with the SPR detection module as shown in Fig.…”

Section: Surface Plasmon Resonance Biosensor By Image Acquisitionmentioning

confidence: 99%

“…3d) was determined by correlating the light maximum transmission redshift to the refractive index for one nanohole array [22,34]. The sensitivity curve highlights the great ability of the substrate to monitor refractive index variations [26]. This feature makes the substrate efficient for detecting molecules on the metal surface (sensor).…”

Section: Nanohole Array Characterizationmentioning

confidence: 99%

Complete experimental and theoretical characterization of nonlinear concentration gradient generator microfluidic device for analytical purposes

et al. 2021

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Microfluidic devices that generate stable concentration gradients are efficient instruments for automated calibration for analytical and bioanalytical systems. However, little attention has been paid to the development of reusable microfluidic concentration gradient generators, which can be useful for a range of species through mathematical characterization. In this work, we develop a microfluidic device based on three steps of serial dilution that were able to generate nonlinear concentration gradient for dyes and biomolecules. The microfluidic device was described mathematically, statistically and was suitable for reusable analytical and bioanalytical analysis. The device reproducibility was assessed by experimental tests, which have shown the same gradient concentration profile for different dyes and statistical reproducibility with 95% confidence interval for bovine serum albumin (BSA). Moreover, the experimental data converged well with those obtained by computational fluid dynamics simulation. Applicability was verified by coupling the microfluidic device to a surface plasmon resonance (SPR) biosensor, based on nanohole arrays with sensitivity of 358.7 nm RIU −1 determined by white-light SPR excitation exposed to different D-(+)-glucose aqueous solutions with 1.3361-1.4035 refractive index interval. The transmission light intensities obtained by the array of images allowed to quantify a pseudo-unknown BSA sample (160 µg mL −1 ) at 138 µg mL −1 . The SPR analysis has been validated in parallel by fluorescence emissions, which showed a concentration of 154.8 ± 16.6 µg mL −1 .

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Detection of tumor necrosis factor-alpha cytokine from the blood serum of a rat infected with Pb18 by a gold nanohole array-based plasmonic biosensor

Cited by 7 publications

References 64 publications

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Plasmonic Metasurfaces for Medical Diagnosis Applications: A Review

Complete experimental and theoretical characterization of nonlinear concentration gradient generator microfluidic device for analytical purposes

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