Procyanidins from hawthorn (<i>Crataegus pinnatifida</i>) alleviate lipid metabolism disorder <i>via</i> inhibiting insulin resistance and oxidative stress, normalizing the gut microbiota structure and intestinal barrier, and further suppressing hepatic inflammation and lipid accumulation

Han, Xue; Zhao, Wen; Zhou, Qian; Chen, Hong; Yuan, Jing; Zhang, Xiaofu; Zhang, Zhisheng

doi:10.1039/d2fo00836j

Cited by 19 publications

(14 citation statements)

References 69 publications

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“…A study has shown that hawthorn proanthocyanidins can significantly improve the blood lipid levels in rats fed a HFD, which may be closely related to the anti-lipid peroxidation and anti-LDL oxidation properties of hawthorn proanthocyanidins. 42 These results were confirmed in another study, which showed that proanthocyanidins could improve the AS risk index by significantly reducing LDL-C, non-HDL-C, plasma TG, free fatty acids (FFAs), and apoB48 levels. 94 Studies have also shown that hawthorn also has a significant regulatory effect on serum total cholesterol (TC) and TG levels.…”

Section: Reviewmentioning

confidence: 69%

Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases

Zhang

Pan

et al. 2023

Food Funct.

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Section: Reviewmentioning

confidence: 69%

Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases

Zhang

Pan

et al. 2023

Food Funct.

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“…Procyanidins from hawthorn supplementation significantly relieved lipid accumulation in the serum and liver, and protected the structure of liver in lipid metabolism disorder (LMD) rats. Procyanidins from hawthorn (HPC) especially increased the abundances of Akkermansia , Bacteroides and Adlercreutzia , and decreased Lactobacillus , Bifidobacterium , Blautia , Lachnospiraceae and Subdoligranulum , which could also regulated the structure of intestinal flora ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial

et al. 2023

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ObjectiveAs a metabolic disease, one important feature of non-alcoholic fatty liver disease (NAFLD) is the disturbance of the intestinal flora. Spleen-strengthening and liver-draining formula (SLF) is a formula formed according to the theory of “One Qi Circulation” (Qing Dynasty, 1749) of Traditional Chinese Medicine (TCM), which has shown significant therapeutic effect in patients with NAFLD in a preliminary clinical observation. In this study, we aim to explore the mechanism of SLF against NAFLD, especially its effect on glucolipid metabolism, from the perspective of intestinal flora.MethodsA prospective, randomized, controlled clinical study was designed to observe the efficacy and safety of SLF in the treatment of NAFLD. The study participants were randomly and evenly divided into control group and treatment group (SLF group). The control group made lifestyle adjustments, while the SLF group was treated with SLF on top of the control group. Both groups were participated in the study for 12 consecutive weeks. Furthermore, the feces of the two groups were collected before and after treatment. The intestinal flora of each group and healthy control (HC) were detected utilizing 16S rRNA gene sequencing.ResultsCompared with the control group, the SLF group showed significant improvements in liver function, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM), meanwhile, patients had significantly lower lipid and homeostasis model assessment of insulin resistance (HOMA-IR) with better security. Intestinal flora 16S rRNA gene sequencing results indicated reduced flora diversity and altered species abundance in patients with NAFLD. At the phylum level, Desulfobacterota levels were reduced. Although Firmicutes and Bacteroidetes did not differ significantly between HC and NAFLD, when grouped by alanine transaminase (ALT) and aspartate transaminase (AST) levels in NAFLD, Firmicutes levels were significantly higher in patients with ALT or AST abnormalities, while Bacteroidetes was significantly lower. Clinical correlation analysis showed that Firmicutes positively correlated with gender, age, ALT, AST, LSM, and Fibroscan-AST (FAST) score, while the opposite was true for Bacteroidetes. At the genus level, the levels of Alistipes, Bilophila, Butyricimonas, Coprococcus, Lachnospiraceae_NK4A136 group Phascolarctobacterium, Ruminococcus, UCG-002, and UCG-003 were reduced, whereas abundance of Tyzzerella increased. There was no statistically significant difference in Firmicutes and Bacteroidota levels in the SLF group before and after treatment, but both bacteria tended to retrace. At the genus level, Coprococcus (Lachnospiraceae family), Lachnospiraceae_NK4A136 group (Lachnospiraceae family), and Ruminococcus (Ruminococcaceae family) were significantly higher in the SLF group after treatment, and there was also a tendency for Bilophila (Desulfovibrionaceae family) to be back-regulated toward HC.ConclusionsSLF can improve liver function and glucolipid metabolism in patients with NAFLD and lower down liver fat content to some extent. SLF could be carried out by regulating the disturbance of intestinal flora, especially Coprococcus, Lachnospiraceae_NK4A136 group, and Ruminococcus genus.

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“…Western blot analysis was carried out as described in Han et al, with slight modifications . Protein was extracted from renal tissue samples with cell lysis buffer according to the manufacturer’s instructions, and the BCA detection kit was used to determine the protein concentration.…”

Section: Methodsmentioning

confidence: 99%

“…Western blot analysis was carried out as described in Han et al, with slight modifications. 39 Protein was extracted from renal tissue samples with cell lysis buffer according to the manufacturer's instructions, and the BCA detection kit was used to determine the protein concentration. Protein samples were separated by 10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and proteins were transferred to polyvinylidene fluoride membranes.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Quinoa (Chenopodium quinoa Willd) Bran Saponins Alleviate Hyperuricemia and Inhibit Renal Injury by Regulating the PI3K/AKT/NFκB Signaling Pathway and Uric Acid Transport

Lin

Zhou

et al. 2023

J. Agric. Food Chem.

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Triterpenoids derived from natural products can exert antihyperuricemic effects. Here, we investigated the antihyperuricemic activity and mechanism of quinoa bran saponins (QBSs) in hyperuricemic mouse and cell models. The QBS4 fraction, with the highest saponin content, was used. Fourier-transform infrared, high-performance liquid chromatography, and ultrahigh-performance liquid chromatography−mass spectrometry identified 11 individual saponins in QBS4, of which the main components were hederagenin and oleanolic acid. The QBS4 effects on hyperuricemic mice (induced by adenine and potassium oxonate) were then studied. QBS4 reduced the levels of uric acid (UA), serum urea nitrogen, creatinine, and lipids in mice with hyperuricemia (HUA) and decreased renal inflammation and renal damage. Molecular analysis revealed that QBS4 may alleviate HUA by regulating the expression of key genes involved in the transport of UA and by inhibiting the activation of the PI3K/AKT/ NFκB inflammatory signaling pathway. In conclusion, QBS4 has promise for using as a natural dietary supplement to treat and prevent HUA.

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Procyanidins from hawthorn (Crataegus pinnatifida) alleviate lipid metabolism disorder via inhibiting insulin resistance and oxidative stress, normalizing the gut microbiota structure and intestinal barrier, and further suppressing hepatic inflammation and lipid accumulation

Abstract: Recently, lipid metabolism disorder (LMD) has been regarded as a risky factor leading to multiple diseases and affecting human health. Procyanidins have been reported to be the potential therapy for...

Cited by 19 publications

References 69 publications

Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases

Advances in the study of the vascular protective effects and molecular mechanisms of hawthorn (Crataegus anamesa Sarg.) extracts in cardiovascular diseases

The spleen-strengthening and liver-draining herbal formula treatment of non-alcoholic fatty liver disease by regulation of intestinal flora in clinical trial

Quinoa (Chenopodium quinoa Willd) Bran Saponins Alleviate Hyperuricemia and Inhibit Renal Injury by Regulating the PI3K/AKT/NFκB Signaling Pathway and Uric Acid Transport

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