Procyanidin attenuates weight gain and modifies the gut microbiota in high fat diet induced obese mice

Zheng, Shujuan; Huang, Kunlun; Zhao, Changhui; Xu, Wentao; Sheng, Yao; Luo, Yunbo; He, Xiaoyun

doi:10.1016/j.jff.2018.09.007

Cited by 53 publications

(48 citation statements)

References 45 publications

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“…Significantly higher food consumption was recorded in three studies [2-PPC [ 41 , 50 ], 1-PE [ 73 ], while 24 studies reported non-significant difference in energy/food intake [ 45 , 46 , 47 , 51 , 52 , 57 , 59 , 60 , 62 , 63 , 66 , 74 , 75 , 80 ] ( Figure S4 ). As for bodyweight, thirty studies (67%) recorded a significant drop post-treatment, of which 16 with PPC [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 50 , 52 , 53 , 54 , 56 , 57 ], and 15 with PE [ 60 , 61 , 63 , 65 , 66 , 68 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 81 ]. Non-significant observations were made in 19 studies [11-PPC [ 37 ...…”

Section: Resultsmentioning

confidence: 99%

“…The adiposity in animal models was presented as the weight of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) or total body fat (TBF). The VAT was significantly reduced in 24 studies [PPC-14 [ 37 , 38 , 39 , 41 , 42 , 43 , 44 , 46 , 48 , 50 , 51 , 52 , 53 , 54 , 57 ], PE-[ 61 , 63 , 65 , 68 , 71 , 72 , 73 , 77 , 78 , 81 ]], and 11 studies reported non-significance [ 40 , 44 , 45 , 49 , 65 , 67 , 69 , 70 , 76 , 80 , 81 ]. As for the SAT, seven studies showed a significant reduction [4-PPC [ 35 , 37 , 40 , 42 , 43 ], 3-PE [ 61 , 62 , 73 ]], while 10 studies showed non-significant findings [ 36 , 38 , 39 , 44 , 45 , 46 , 48 ,…”

Section: Resultsmentioning

confidence: 99%

“…Total cholesterol was significantly lowered in 11 studies following the administration of PPC [ 37 , 38 , 41 , 42 , 43 , 46 , 50 , 52 , 54 , 56 , 57 , 58 ] and eight studies for PE [ 63 , 68 , 71 , 73 , 74 , 75 , 76 , 79 , 81 ]. One study reported a significant increase with PPC [ 45 ]. Thirteen studies reported non-significant findings [ 35 , 36 , 38 , 46 , 49 , 55 , 56 , 66 , 67 , 71 , 72 , 79 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies that used PPC significantly lowered LDL [ 36 , 38 , 44 , 46 , 52 , 54 , 56 , 57 , 58 ] level and eight studies showed a similar result with PE [ 63 , 65 , 66 , 71 , 76 , 77 , 79 , 81 ]. As for the HDL level, four studies recorded a significant reduction [3-PPC [ 38 , 46 , 56 ], 1-PE [ 63 ]], and five studies a significant increment [5-PPC [ 44 , 45 , 52 , 54 , 55 ], 2-PE [ 66 , 81 ]] ( Figure S6 ).…”

Section: Resultsmentioning

confidence: 99%

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Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Moorthy

Sundralingam

Palanisamy

2021

Foods

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Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera Akkermansia, Bacteroides, Blautia, Roseburia, Bifidobacteria, Lactobacillus, Alistipes, and Desulfovibrio. Polyphenols’ anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Moorthy

Sundralingam

Palanisamy

2021

Foods

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“…Lingonberries are also a rich source of proanthocyanidins [60,69] and anthocyanins, particularly cyanidin-3-galactoside, cyanidin-3-arabinoside, and cyanidin-3-glucoside [70,71]. Proanthocyanidins have been reported to contribute to the reduced weight gain and hypolipidemic effects of berry-derived preparations in animal models of obesity [40,72,73] while purified anthocyanins from mulberry (M. australis P.) and cherry (Prunus avium L.) prevented obesogenic diet induced weight gain, oxidative stress and inflammation in mice [74,75]. Lingonberry contains also the stilbenoid compound resveratrol (together with its glycosylated derivative piceid), which is a strong antioxidant with anti-inflammatory properties [76][77][78].…”

Section: Plos Onementioning

confidence: 99%

Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

et al. 2020

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Obesity is a constantly increasing health problem worldwide. It is associated with a systemic low-grade inflammation, which contributes to the development of metabolic disorders and comorbidities such as type 2 diabetes. Diet has an important role in the prevention of obesity and its adverse health effects; as a part of healthy diet, polyphenolrich berries, such as lingonberry (Vaccinium vitis-idaea L.) have been proposed to have health-promoting effects. In the present study, we investigated the effects of lingonberry supplementation on high-fat diet induced metabolic and inflammatory changes in a mouse model of obesity. Thirty male C57BL/6N mice were divided into three groups (n = 10/ group) to receive low-fat (LF), high-fat (HF) and lingonberry-supplemented high-fat (HF +LGB) diet for six weeks. Low-fat and high-fat diet contained 10% and 46% of energy from fat, respectively. Lingonberry supplementation prevented the high-fat diet induced adverse changes in blood cholesterol and glucose levels and had a moderate effect on the weight and visceral fat gain, which were 26% and 25% lower, respectively, in the lingonberry group than in the high-fat diet control group. Interestingly, lingonberry supplementation also restrained the high-fat diet induced increases in the circulating levels of the proinflammatory adipocytokine leptin (by 36%) and the inflammatory acute phase reactant serum amyloid A (SAA; by 85%). Similar beneficial effects were discovered in the hepatic expression of the inflammatory factors CXCL-14, S100A10 and SAA by lingonberry supplementation. In conclusion, the present results indicate that lingonberry supplementation significantly prevents high-fat diet induced metabolic and inflammatory changes in a murine model of obesity. The results encourage evaluation of lingonberries as a part of healthy diet against obesity and its comorbidities.

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Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art

2021

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The human intestine contains an intricate ecological community of bacteria, referred as the gut microbiota, which plays a pivotal role in the host homeostasis. Multiple factors could interfere with this delicate balance, thus causing a disruption of the microbiota equilibrium, the so called dysbiosis. Gut microbiota dysbiosis is involved in gastrointestinal and extra-intestinal metabolic diseases, as obesity and diabetes. Polyphenols, present in a broad range of plant foods, are known to have numerous health benefits; however, their beneficial effect on pre-existing dysbiosis is less clear. Indeed, in most of the conducted animal studies the administration of polyphenols or foods rich in polyphenols occurred simultaneously with the induction of the pathology to be examined, then analyzing the preventive action of the polyphenols on the onset of dysbiosis, while very low studies analyzed the modulatory activity of polyphenols on the pre-existing dysbiosis. For this reason, the present review aims to update the current information about the modulation of the preestablished gut microbiota dysbiosis by dietary phenolic compounds in a broad range of disorders in both animal studies and human trials, distinguishing the preventive or treatment approaches in animal studies. The described studies highlight that dietary polyphenols, exerting prebiotic-like effects, can modulate the pre-existing dysbiosis stimulating the growth of beneficial bacteria and inhibiting pathogenic bacteria in both animal models and humans. Anyway,

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Procyanidin attenuates weight gain and modifies the gut microbiota in high fat diet induced obese mice

Cited by 53 publications

References 45 publications

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Beneficial effects of lingonberry (Vaccinium vitis-idaea L.) supplementation on metabolic and inflammatory adverse effects induced by high-fat diet in a mouse model of obesity

Polyphenols as modulators of pre‐established gut microbiota dysbiosis: State‐of‐the‐art

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