Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Moorthy, Mohanambal; Sundralingam, Usha; Palanisamy, Uma Devi

doi:10.3390/foods10020299

Cited by 38 publications

(27 citation statements)

References 137 publications

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“…[ 35 ] The polyphenol content of SWSO is lower than sesame oil (250 mg GAE kg −1 ), higher than soybean oil (<60 mg GAE kg −1 ), peanut oil (<60 mg GAE kg −1 ), camellia oil (<30 mg GAE kg −1 ), and pumpkin oil (<30 mg GAE kg −1 ), and comparable to olive oil. [ 36,37 ] In addition to antioxidant effects, polyphenols can also effectively prevent the derivatives (visceral adiposity, plasma triacylglycerol (TAG), and glucose homeostasis) produced by high‐fat food from causing adverse effects on the human body, [ 38 ] which may be promoted as a future benefit of consuming SWSO oil.…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Characteristics and Functional Properties of Seed Oil from Four Different Cultivars of S. Wilsoniana

Wen

Sun

et al. 2021

Euro J Lipid Sci & Tech

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A study is conducted to explore the under‐utilized resources of Swida wilsoniana seed oil (SWSO). Physicochemical properties of four cultivars of SWSO and their fatty acid composition, phytochemicals, oxidation stabilities, and antioxidant capacities are evaluated. The results indicate that SWSO is abundant in unsaturated fatty acids (76.02–82.43%) and contained a high phytochemical content. Gamma‐tocotrienol (206.03 ± 0.21–215.84 ± 0.17 mg kg−1), β‐amyrin (107.12 ± 0.27–192.30 ± 1.17 mg kg−1), and betulin (32.82 ± 0.59–88.20 ± 0.37 mg kg−1) are major components of SWSO compared to familiar oils. The induction period (5.08–5.80 h) is negatively correlated with unsaturated fatty acid content (r = −0.948**, P < 0.01), particularly linoleic acid (r = −0.938**, P < 0.01). A high antioxidant capacity is observed in SWSO which is primarily attributed to tocopherol/tocotrienol content (0.832*–0.963**). SWSO can be regarded as a new resource and a high‐quality ingredient for dietary foods and other applications. Practical applications: The favorable physicochemical characteristics and functional properties of SWSO indicate that it may be used as a novel and daily edible oil through moderate refining. It also exhibits promise to protect the artery and liver as a special oil for use as shortening and frying because of its ideal FAC and antioxidant capacity. In addition, SWSO may be suitable for the cosmetics industry. Furthermore, more varieties should be obtained to verify and refine the correlations between chemical composition and antioxidant properties. In addition, the specific phenolics in SWSO should be identified to better characterize the relationship between polyphenol content and antioxidant capacity.

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Section: Discussionmentioning

confidence: 99%

Physicochemical Characteristics and Functional Properties of Seed Oil from Four Different Cultivars of S. Wilsoniana

Wen

Sun

et al. 2021

Euro J Lipid Sci & Tech

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“…An important point, studies on the potential prebiotic effect of polyphenols on the composition and function of the gut microbiota, gut permeability, gut-derived proinflammatory stimuli, have increased considerably, and the results have been linked to the high production of anti-inflammatory molecules such as interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13), and adiponectin [ 31 , 32 , 33 , 34 ]. Moreover, dietary polyphenols can contribute substantially to reduce the frequency of oxidative stress-induced damage triggered by inflammation or infectious process, and thus, it plays a vital role in chemoprevention through different action mechanisms such as nuclear factor erythroid 2-related factor 2 (Nrf2) and Nrf2-antioxidant response element (ARE) pathway, and phase I and phase II detoxifying enzymes [ 35 ].…”

Section: Healthy Effects Of Polyphenols and Antioxidantsmentioning

confidence: 99%

Plant-Based Polyphenols: Anti-Helicobacter pylori Effect and Improvement of Gut Microbiota

2022

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Helicobacter pylori (H. pylori) infection affects more than half of the world’s population, and thus, about 10 to 20% of people with H. pylori suffer from peptic ulcers, which may ultimately lead to gastric cancer. The increase in antibiotic resistance and susceptibility has encouraged the search for new alternative therapies to eradicate this pathogen. Several plant species are essential sources of polyphenols, and these bioactive compounds have demonstrated health-promoting properties, such as the gut microbiota stimulation, inflammation reduction, and bactericidal effect. Therefore, this review aims to discuss the potential effect of plant-based polyphenols against H. pylori and their role in the gut microbiota improvement.

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“…In addition, many environmental factors such as diet, bedding, caging, housing density, and the mode of birth delivery can contribute to the variance in the microbiome composition between mice [ 79 ]. For example, preclinical and clinical studies demonstrate that dietary polyphenols with probiotic properties can impact GM composition, gut permeability, metabolism, and immune responses [ 80 , 81 ]. The consumption of polyphenols modulates the relative abundance of Firmicutes to Bacteroidetes [ 82 ].…”

Section: Factors Contributing To Gut Microbiome Variationmentioning

confidence: 99%

Consideration of Gut Microbiome in Murine Models of Diseases

2021

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The gut microbiome (GM), a complex community of bacteria, viruses, protozoa, and fungi located in the gut of humans and animals, plays significant roles in host health and disease. Animal models are widely used to investigate human diseases in biomedical research and the GM within animal models can change due to the impact of many factors, such as the vendor, husbandry, and environment. Notably, variations in GM can contribute to differences in disease model phenotypes, which can result in poor reproducibility in biomedical research. Variation in the gut microbiome can also impact the translatability of animal models. For example, standard lab mice have different pathogen exposure experiences when compared to wild or pet store mice. As humans have antigen experiences that are more similar to the latter, the use of lab mice with more simplified microbiomes may not yield optimally translatable data. Additionally, the literature describes many methods to manipulate the GM and differences between these methods can also result in differing interpretations of outcomes measures. In this review, we focus on the GM as a potential contributor to the poor reproducibility and translatability of mouse models of disease. First, we summarize the important role of GM in host disease and health through different gut–organ axes and the close association between GM and disease susceptibility through colonization resistance, immune response, and metabolic pathways. Then, we focus on the variation in the microbiome in mouse models of disease and address how this variation can potentially impact disease phenotypes and subsequently influence research reproducibility and translatability. We also discuss the variations between genetic substrains as potential factors that cause poor reproducibility via their effects on the microbiome. In addition, we discuss the utility of complex microbiomes in prospective studies and how manipulation of the GM through differing transfer methods can impact model phenotypes. Lastly, we emphasize the need to explore appropriate methods of GM characterization and manipulation.

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Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Cited by 38 publications

References 137 publications

Physicochemical Characteristics and Functional Properties of Seed Oil from Four Different Cultivars of S. Wilsoniana

Physicochemical Characteristics and Functional Properties of Seed Oil from Four Different Cultivars of S. Wilsoniana

Plant-Based Polyphenols: Anti-Helicobacter pylori Effect and Improvement of Gut Microbiota

Consideration of Gut Microbiome in Murine Models of Diseases

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