Procollagen type III amino terminal propeptide concentrations in dogs with idiopathic pulmonary fibrosis compared with chronic bronchitis and eosinophilic bronchopneumopathy

Heikkilä, Heikki; Krafft, Émilie; Jespers, Pascale; McEntee, Kathleen; Rajamäki, Minna; Clercx, Cécile

doi:10.1016/j.tvjl.2012.07.023

Cited by 14 publications

(23 citation statements)

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“…[8,10,25,26] Milman et al [25] investigated 27 patients with pulmonary fibrosis and 24 healthy controls and found that serum PIIINP and HA levels were not significantly different between the 2 groups but were higher in the patients with progressive disease than the patients with stable disease. Low et al [8] measured the PIIINP levels in serum and bronchoalveolar lavage fluid of 24 patients with IPF and 29 healthy individuals and found that the patients with IPF had significantly elevated PIIINP in serum and bronchoalveolar lavage fluid.…”

Section: Discussionmentioning

confidence: 99%

“…In a dog model of IPF, serum PIIINP level was similar to that in healthy dogs. [26] Inokoshi et al [10] reported that serum HA was significantly increased in patients with chronic interstitial pneumonia compared with healthy controls and was further elevated in patients with AE of interstitial pneumonia. Compared with the previous studies, which included small number of patients and only focused on 1 or 2 of the 4 ECM molecules, [8,10,24,25] the present study investigated serum levels of the 4 ECM molecules together in 323 patients and 160 healthy controls.…”

Section: Discussionmentioning

confidence: 99%

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Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

et al. 2017

Medicine

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Noninvasive and convenient tests to assess pulmonary fibrosis and disease progression in interstitial lung diseases (ILDs) are currently unavailable. The extracellular matrix molecules, laminin (LN), type IV collagen (IVC), procollagen III N-terminal peptide (PIIINP), and hyaluronic acid (HA) are involved in ILD development and progression. This study aims to investigate the association of disease progression and serum levels of LN, IVC, PIIINP, and HA in patients with ILD. This retrospective study included 323 patients (162 cases of idiopathic pulmonary fibrosis [IPF] and 161 cases of connective tissue diseases ILD [CTD-ILD]) treated in Shanghai Pulmonary Hospital between January 2013 and January 2015 and 160 healthy controls. Serum LN, IVC, PIIINP, and HA were analyzed by radioimmunoassay. Data of the percentage of forced vital capacity in the prediction value (FVC%pred), the percentage of diffusing capacity of the lung for carbon monoxide in the prediction value (DLCO%pred), high resolution computed tomography (HRCT) score, and patient mortality were collected. Serum LN, IVC, PIIINP, and HA were significantly increased in the patients with IPF or CTD-ILD compared with the healthy controls (all P < .05) and were further elevated in the acute exacerbation cases (all P < .05). Serum LN, IVC, PIIINP, and HA positively correlated with HRCT score and negatively correlated with FVC%pred and DLCO%pred significantly in the patients (all P < .05). The survived patients had significantly lower serum LN, IVC, PIIINP, and HA than the dead patients (all P < .05). Serum levels of LN, IVC, PIIINP, and HA may reflect ILD progression and may be indicators for the severity of ILDs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

et al. 2017

Medicine

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“…Breed predisposition suggests a genetic basis for the disease; however, the pathogenesis of IPF is poorly understood. Endothelin‐1 and procollagen aminopeptide type III have been studied as biomarkers of IPF and are probably involved in the pathogenesis. Recently, a pulmonary gene expression profile analysis has showed increased pulmonary expression of genes encoding cytokines such as CCL2, CCL7, IL8, CXCL14, and the fibroblast activation protein …”

mentioning

confidence: 99%

“…integrin chain b6 ITGB8 integrin chain b8 LTBP latent transforming growth factor binding protein P-Smad2/3 phosphorylated Smad2/3 qRT-PCR quantitative reverse transcriptase PCR RPS18 ribosomal protein S18 TBP TATA box binding protein TGFbR1 transforming growth factor b receptor type 1 TGF-b transforming growth factor b THBS1 thrombospondin-1 WHWT West Highland white Terrier understood. Endothelin-1 6 and procollagen aminopeptide type III 7 have been studied as biomarkers of IPF and are probably involved in the pathogenesis. Recently, a pulmonary gene expression profile analysis has showed increased pulmonary expression of genes encoding cytokines such as CCL2, CCL7, IL8, CXCL14, and the fibroblast activation protein.…”

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confidence: 99%

Transforming Growth Factor Beta 1 Activation, Storage, and Signaling Pathways in Idiopathic Pulmonary Fibrosis in Dogs

Krafft

Lybaert

Roels

et al. 2014

Veterinary Internal Medicne

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BackgroundThe pathogenesis of idiopathic pulmonary fibrosis (IPF) in dogs is poorly understood. In human, transforming growth factor β1 (TGF‐β1) is considered central in the pathogenesis.ObjectivesTo investigate TGF‐β1 pathway in IPF.AnimalsLung tissues from 12 affected and 11 control dogs. Serum from 16 affected West Highland white Terriers (WHWTs) and healthy dogs from predisposed (13 WHWTs, 12 Scottish Terriers and 13 Bichons Frise) and nonpredisposed breeds (10 Whippets, 10 Belgian shepherds, 8 Labradors).MethodsIn this prospective study, immunohistochemistry was used to evaluate expression and localization of TGF‐β1 protein and proteins involved in TGF‐β1 signaling (TGF‐β receptor type I and phospho‐Smad2/3). Pulmonary expression of TGF‐β1 and molecules involved in its storage (latent TGF‐β binding proteins [LTBP] 1, 2, and 4), activation (ανβ6 and ανβ8 integrins, thrombospondin‐1) and signal inhibition (Smad 7) was analyzed by quantitative reverse transcriptase PCR. Circulating TGF‐β1 concentration was measured by ELISA.ResultsIn IPF, high level of TGF‐β1 protein was found in areas of fibrosis, epithelial cells had strong expression of TGF‐β receptor type 1 and phospho‐Smad2/3, gene expression was decreased for LTBP 4 (P = .009) and β8 integrin (P < .001) and increased for thrombospondin‐1 (P = .016); no difference was seen for Smad7, LTBP1 and 2. Serum TGF‐β1 concentration was higher in predisposed compared with nonpredisposed breeds (P < .0001).Conclusions and Clinical ImportanceThis study identified an enhanced TGF‐β1 signaling activity in IPF. TGF‐β1 storage and activation proteins with altered expression represent potential therapeutic targets. Higher circulating TGF‐β1 concentration in predisposed breeds might partly explain their susceptibility for IPF.

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“…Definitive diagnosis requires histopathologic examination [1,6]. Recently, diagnostic biomarkers such as endothelin-1 and procollagen type III amino terminal propeptide have been shown to be elevated in pulmonary fibrosis [2,9] but further studies are necessary to consolidate the approval of use of such biomarkers for the diagnosis of pulmonary fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Computed tomography imaging of a leopard tortoise (Geochelone pardalis pardalis) with confirmed pulmonary fibrosis: a case report

et al. 2013

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An approximately 20-year-old, female Leopard tortoise (Geochelone pardalis pardalis) was presented with dypsnea, wheezing, anorexia and depression. Whole body radiographs revealed generalized diffuse unstructured ‘interstitial lung pattern’ with thickened pulmonary septae while computed tomography (CT) showed emphysematous lung parenchyma and thickened pulmonary septae bordered by irregular ground-glass opacity with smaller areas of ‘honeycombing’. These imaging findings together with histopathologic findings were compatible with chronic, extensive ‘interstitial’ pulmonary fibrosis.

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Procollagen type III amino terminal propeptide concentrations in dogs with idiopathic pulmonary fibrosis compared with chronic bronchitis and eosinophilic bronchopneumopathy

Cited by 14 publications

References 26 publications

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

Association of serum levels of laminin, type IV collagen, procollagen III N-terminal peptide, and hyaluronic acid with the progression of interstitial lung disease

Transforming Growth Factor Beta 1 Activation, Storage, and Signaling Pathways in Idiopathic Pulmonary Fibrosis in Dogs

Computed tomography imaging of a leopard tortoise (Geochelone pardalis pardalis) with confirmed pulmonary fibrosis: a case report

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