Procoagulant activity in children with community acquired pneumonia, pleural effusion and empyema

Abstract

The results suggest that plasma level of D-dimer can give an additional contribution for the evaluation of the severity of CAP and its complications in children.

Coagulation and inflammation biomarkers may help predict the severity of community‐acquired pneumonia

“…23 Michelin et al proposed that plasma D-D levels may help in evaluating the severity of CAP in children. 24 The findings from the present study are in agreement with these data, and suggest that serum D-D concentrations are correlated with the severity and predict the outcome of CAP. More specifically, serum D-D levels >600 ng/mL appear to be useful for discriminating between mild and severe CAP.…”

Die CAP im Kindesalter diagnostizieren und behandeln

“…Bei stationären Aufnahmen ist weiterhin eine Bestimmung des Blutzuckers, des Harnsto s und der Elektrolyte sinnvoll, um das Ausmaß der Dehydratation abzuschätzen und ein Schwartz-BartterSyndrom (SIADH) nicht zu übersehen [2]. In schweren Fällen sind deutlich erhöhte D-Dimere hinweisend auf Komplikationen wie Pleuraempy eme [9].…”

Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix

“…While the underlying mechanisms for empyema formation are not known, the incidence of PPE in children with pneumonia has increased during the last decade (Byington et al ., 2009; Li and Tancredi, 2009). Fibronectin‐ and plasminogen‐binding proteins such as PavB might be important for PPE formation because pleural effusions contain high levels of fibrinogen and plasminogen (Philip‐Joet et al ., 1995; Michelin et al ., 2008) and fibrin clots are a major component of the effusions (Salzberg, 1956).…”