Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1

Beer, Zachery; Chwiesko, Caroline; Sauvage, Magdalena

doi:10.1016/j.nlm.2014.03.001

Cited by 49 publications

(42 citation statements)

References 49 publications

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“…Furthermore, while most data presented in this meta‐analysis are derived from activity patterns in dorsal hippocampal regions, we anticipate similar nonuniform recruitment probabilities in intermediate and ventral hippocampal areas given the increased sparsity of place fields in ventral regions. In support of this, Beer et al () demonstrated that the number of Arc + neurons declines along the dorso‐ventral axis after a behavioral task.…”

Section: Discussionmentioning

confidence: 84%

Nonuniform allocation of hippocampal neurons to place fields across all hippocampal subfields

et al. 2016

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The mechanisms governing how the hippocampus selects neurons to exhibit place fields are not well understood. A default assumption in some previous studies was the uniform random draw with replacement (URDWR) model, which, theoretically, maximizes spatial "pattern separation", and predicts a Poisson distribution of the numbers of place fields expressed by a given cell per unit area. The actual distribution of mean firing rates exhibited by a population of hippocampal neurons, however, is approximately exponential or log-normal in a given environment and these rates are somewhat correlated across multiple places, at least under some conditions. The advantage of neural activity-dependent immediate-early gene (IEG) analysis, as a proxy for electrophysiological recording, is the ability to obtain much larger samples of cells, even those whose activity is so sparse that they are overlooked in recording studies. Thus, a more accurate representation of the activation statistics can potentially be achieved. Some previous IEG studies that examined behavior-driven IEG expression in CA1 appear to support URDWR. There was, however, in some of the same studies, an under-recruitment of dentate gyrus granule cells, indicating a highly skewed excitability distribution, which is inconsistent with URDWR. Although it was suggested that this skewness might be related to increased excitability of recently generated granule cells, we show here that CA1, CA3, and subiculum also exhibit cumulative under-recruitment of neurons. Thus, a highly skewed excitability distribution is a general principle common to all major hippocampal subfields. Finally, a more detailed analysis of the frequency distributions of IEG intranuclear transcription foci suggests that a large fraction of hippocampal neurons is virtually silent, even during sleep. Whether the skewing of the excitability distribution is cell-intrinsic or a network phenomenon, and the degree to which this excitability is fixed or possibly time-varying are open questions for future studies. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 84%

Nonuniform allocation of hippocampal neurons to place fields across all hippocampal subfields

et al. 2016

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“…These aspects of the hippocampal functioning have shown to be induced by EE and related with better spatial memory performance (Artola et al, 2006;Duffy et al, 2001;Foster and Dumas, 2001;Foster et al, 1996), so it is likely that the increase of Synapsin I after EE in the vCA3 was a consequence of a higher complexity of CA3 pyramidal neurons promoting higher levels of neurotransmission, and therefore, LTP. Interestingly, recent studies have found that the activation levels of the vCA3 during a spatial memory task were similar to the dorsal part, in contrast to the traditional role of the ventral hippocampus only in emotional functions (Beer et al, 2014).…”

Section: Discussionmentioning

confidence: 91%

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Sampedro-Piquero

Árias

Begega

2014

Experimental Gerontology

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“…In the current study, the memory deficits of rats in the UCMS group were accompanied by the reduction in the level of BDNF expression in the CA1 and CA3 subfields of hippocampus. CA1 and CA3 subfields were chosen due their known involvement with the specific tasks utilized in the current study [35,45,46]. Studies that contained behavioral assessments have demonstrated (although not always linear) a relationship between the hippocampal BDNF levels and depression and/or memory scores [9,10,40,47] and a correlation between effectiveness of treatments and BDNF in the hippocampus [10,41,47].…”

Section: Discussionmentioning

confidence: 99%

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

Şahin

Karson

Balcı

et al. 2015

Behavioural Brain Research

102

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Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1

Cited by 49 publications

References 49 publications

Nonuniform allocation of hippocampal neurons to place fields across all hippocampal subfields

Nonuniform allocation of hippocampal neurons to place fields across all hippocampal subfields

Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression

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