Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Sampedro-Piquero, Patricia; Árias, Jorge L.; Begega, Azucena

doi:10.1016/j.exger.2014.09.004

Cited by 18 publications

(19 citation statements)

References 72 publications

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“…Moreover, longitudinal and cross-sectional studies may produce different effects on anxiety and response to novelty. For studies that involve multiple age cohorts, the oldest animals may experience prolonged exposure to an impoverished environment, which can impair cognition (Winocur, 1998;Bell et al, 2009;Diniz et al, 2010;Volkers and Scherder, 2011;Sampedro-Piquero et al, 2014;Diamond, 2018;Sparling et al, 2018;Wang et al, 2018) and increase neophobia/anxiety (Hall et al, 1997;Hellemans et al, 2004). Together, the results highlight how cross-sectional and longitudinal studies may produce differences in the response to novelty.…”

Section: Discussionmentioning

confidence: 92%

“…repeated testing across a number of environments (Hall et al, 1997). In general, environmental enrichment is associated with decreased anxiety (Fox et al, 2006), which can be observed in older animals (Galani et al, 2007;Leal-Galicia et al, 2008;Hughes and Collins, 2010;Sampedro-Piquero et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Relative to cross-sectional studies, longitudinal testing is able to control for batch effects and guard against problems associated with the history of experience (Sabolek et al, 2004). For example, impairments may arise due to an interaction of age and the length of exposure to social isolation or an impoverished environment (Winocur, 1998;Bell et al, 2009;Diniz et al, 2010;Volkers and Scherder, 2011;Sampedro-Piquero et al, 2014;Diamond, 2018;Sparling et al, 2018;Wang et al, 2018). In turn, longitudinal studies need to control for influences that carryover from one testing situation to another.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory

Febo

Rani

Yegla

et al. 2020

Front. Aging Neurosci.

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The current longitudinal study examined factors (sex, physical function, response to novelty, ability to adapt to a shift in light/dark cycle, brain connectivity), which might predict the emergence of impaired memory during aging. Male and female Fisher 344 rats were tested at 6, 12, and 18 months of age. Impaired spatial memory developed in middle-age (12 months), particularly in males, and the propensity for impairment increased with advanced age. A reduced response to novelty was observed over the course of aging, which is inconsistent with cross-sectional studies. This divergence likely resulted from differences in the history of environmental enrichment/impoverishment for cross-sectional and longitudinal studies. Animals that exhibited lower level exploration of the inner region on the open field test exhibited better memory at 12 months. Furthermore, males that exhibited a longer latency to enter a novel environment at 6 months, exhibited better memory at 12 months. For females, memory at 12 months was correlated with the ability to behaviorally adapt to a shift in light/dark cycle. Functional magnetic resonance imaging of the brain, conducted at 12 months, indicated that the decline in memory was associated with altered functional connectivity within different memory systems, most notably between the hippocampus and multiple regions such as the retrosplenial cortex, thalamus, striatum, and amygdala. Overall, some factors, specifically response to novelty at an early age and the capacity to adapt to shifts in light cycle, predicted spatial memory in middle-age, and spatial memory is associated with corresponding changes in brain connectivity. We discuss similarities and differences related to previous longitudinal and cross-sectional studies, as well as the role of sex differences in providing a theoretical framework to guide future longitudinal research on the trajectory of cognitive decline. In addition to demonstrating the power of longitudinal studies, these data highlight the importance of middle-age for identifying potential predictive indicators of sexual dimorphism in the trajectory in brain and cognitive aging.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory

Febo

Rani

Yegla

et al. 2020

Front. Aging Neurosci.

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show abstract

“…Environmental enrichment has been used to improve behavioral and cellular consequences of various neurological and psychiatric disorders in animal models, including Parkinson’s disease, stroke, traumatic brain injury, epilepsy, multiple sclerosis, depression, schizophrenia, and autism spectrum disorders (Burrows, McOmish, Buret, Van den Buuse, & Hannan, 2015; Hannan, 2014; Mazarakis et al, 2014; Pang & Hannan, 2013). In addition, environmental enrichment has been shown to improve learning and memory retention in behavioral tasks such as fear avoidance conditioning, the radial maze, and the Morris water maze (Harati et al, 2011; Harburger, Lambert, & Frick, 2007; Mora-Gallegos et al, 2015; Novkovic, Mittmann, & Manahan-Vaughan, 2015; Sampedro-Piquero, Arias, & Begega, 2014). However, the mechanisms behind environmental enrichment remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have demonstrated that genes related to memory formation, synaptic plasticity, and protein synthesis may be upregulated by a period of environmental enrichment (Lichti et al, 2014; Novkovic et al, 2015; Sampedro-Piquero et al, 2014) including group 1 metabotropic glutamate receptors (mGluR1/5) (Melendez, Gregory, Bardo, & Kalivas, 2004). Indeed, the role of metabotropic glutamate receptor subtype 5 (mGluR5) in learning and memory is well established; mice lacking mGluR5 show impaired learning on the Morris water maze and contextual fear conditioning tasks (Lu et al, 1997), and the daily application of the mGluR5 antagonist 2-methyl-6-(phenylethyl)pyridine (MPEP) causes impairments in working and reference memory in rats (Manahan-Vaughan & Braunewell, 2005).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k

Hullinger

O’Riordan²,

Bürger

2015

Neurobiology of Learning and Memory

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Previous studies from our lab have demonstrated that mild cognitive impairments identified early in life are predictive of cognitive deficits that develop with age, suggesting that enhancements in cognition at an early age can provide a buffer against age-related cognitive decline. Environmental enrichment has been shown to improve learning and memory in the rodent, but the impact of enrichment on synaptic plasticity and the molecular mechanisms behind enrichment are not completely understood. To address these unresolved issues, we have housed 2-month old rats in environmentally enriched (EE), socially enriched (SE), or standard housing (SC) and conducted tests of learning and memory formation at various time intervals. Here we demonstrate that animals that have been exposed to one month of social or environmental enrichment demonstrate enhanced learning and memory relative to standard housed controls. However, we have found that after 4 months EE animals perform better than both SE and SC groups and demonstrate an enhanced hippocampal LTP. Our results demonstrate that this LTP is dependent on mGluR5 signaling, activation of ERK and mTOR signaling cascades, and sustained phosphorylation of p70s6 kinase, thus providing a potential target mechanism for future studies of cognitive enhancement in the rodent.

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Environmental enrichment decreases avoidance responses in the elevated T-maze and delta FosB immunoreactivity in anxiety-related brain regions

Lopes

Souza

Andrade

et al. 2018

Behavioural Brain Research

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Behavioral testing-related changes in the expression of Synapsin I and glucocorticoid receptors in standard and enriched aged Wistar rats

Cited by 18 publications

References 72 publications

Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory

Longitudinal Characterization and Biomarkers of Age and Sex Differences in the Decline of Spatial Memory

Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k

Environmental enrichment decreases avoidance responses in the elevated T-maze and delta FosB immunoreactivity in anxiety-related brain regions

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