Processing gain and noise in multi-electrode impedance cytometers: Comprehensive electrical design methodology and characterization

Xie, Pengfei; Cao, Xinnan; Lin, Zhongtian; Talukder, Niloy; Javanmard, Mehdi

doi:10.1016/j.snb.2016.09.182

Cited by 20 publications

(12 citation statements)

References 13 publications

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“…Multi-electrode impedance sensors provide multiple peaks and unique signatures for single cells and particles, and have been exploited e.g. to increase the signal-to-noise ratio 35 or maximize the throughput via multiplexing. 36 Our chip layout is designed so that the signal trace is a fingerprint from which a new metric encoding for particle trajectory height is obtained.…”

Section: Introductionmentioning

confidence: 99%

Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry

et al. 2017

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Microfluidic impedance cytometry offers a simple non-invasive method for single-cell analysis. Coplanar electrode chips are especially attractive due to ease of fabrication, yielding miniaturized, reproducible, and ultimately low-cost devices. However, their accuracy is challenged by the dependence of the measured signal on particle trajectory within the interrogation volume, that manifests itself as an error in the estimated particle size, unless any kind of focusing system is used. In this paper, we present an original five-electrode coplanar chip enabling accurate particle sizing without the need for focusing. The chip layout is designed to provide a peculiar signal shape from which a new metric correlating with particle trajectory can be extracted. This metric is exploited to correct the estimated size of polystyrene beads of 5.2, 6 and 7 μm nominal diameter, reaching coefficient of variations lower than the manufacturers' quoted values. The potential impact of the proposed device in the field of life sciences is demonstrated with an application to Saccharomyces cerevisiae yeast.

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Section: Introductionmentioning

confidence: 99%

Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry

et al. 2017

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“…Unfortunately, noise also increased with increased number of electrodes, which resulted in no S/N improvement. Nevertheless, this method provided unique signatures improving the accuracy of detection .…”

Section: Principle and Design Approachesmentioning

confidence: 99%

Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review

Václavek

Přikryl

Foret

2018

J of Separation Science

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Resistive pulse sensing is a well‐known and established method for counting and sizing particles in ionic solutions. Throughout its development the technique has been expanded from detection of biological cells to counting nanoparticles and viruses, and even registering individual molecules, e.g., nucleotides in nucleic acids. This technique combined with microfluidic or nanofluidic systems shows great potential for various bioanalytical applications, which were hardly possible before microfabrication gained the present broad adoption. In this review, we provide a comprehensive overview of microfluidic designs along with electrode arrangements with emphasis on applications focusing on bioanalysis and analysis of single cells that were reported within the past five years.

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“…Despite the vast literature (reviewed in [37] up to 2010), single-cell IFC has not yet reached the same maturity and diffusion of ECIS. From the analysis of recent advances in the field of single-cell detection [44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59], the following trends can be highlighted. (1) Smarter and more robust event detection algorithms are emerging.…”

Section: Applicationmentioning

confidence: 99%

“…(1) Smarter and more robust event detection algorithms are emerging. Instead of simply fixing a threshold on the impedance value exceeded by the resistive pulse for each passage, digital segmentation and autocorrelation leveraging the odd symmetry of differential pulses can be used [44], as well as multielectrode structures that, while increasing the input capacitance and the measurement time, produce specific signatures, whose shape can be better identified against noise [45] or improved electrode layout [46]. (2) Combination of IFC with dielectrophoresis (DEP) is increasing for sorting [47], trapping [48], orienting [49], and sensing [50].…”

Section: Applicationmentioning

confidence: 99%

Advances in High-Resolution Microscale Impedance Sensors

Carminati

2017

Journal of Sensors

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Sensors based on impedance transduction have been well consolidated in the industry for decades. Today, the downscaling of the size of sensing elements to micrometric and submicrometric dimensions is enabled by the diffusion of lithographic processes and fostered by the convergence of complementary disciplines such as microelectronics, photonics, biology, electrochemistry, and material science, all focusing on energy and information manipulation at the micro- and nanoscale. Although such a miniaturization trend is pivotal in supporting the pervasiveness of sensors (in the context of mass deployment paradigms such as smart city, home and body monitoring networks, and Internet of Things), it also presents new challenges for the detection electronics, reaching the zeptoFarad domain. In this tutorial review, a selection of examples is illustrated with the purpose of distilling key indications and guidelines for the design of high-resolution impedance readout circuits and sensors. The applications span from biological cells to inertial and ultrasonic MEMS sensors, environmental monitoring, and integrated photonics.

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Processing gain and noise in multi-electrode impedance cytometers: Comprehensive electrical design methodology and characterization

Cited by 20 publications

References 13 publications

Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry

Coplanar electrode microfluidic chip enabling accurate sheathless impedance cytometry

Resistive pulse sensing as particle counting and sizing method in microfluidic systems: Designs and applications review

Advances in High-Resolution Microscale Impedance Sensors

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