Processing and properties of sol-gel bioactive glasses

Zhong, Jiawei; Greenspan, David C.

doi:10.1002/1097-4636(2000)53:6<694::aid-jbm12>3.0.co;2-6

Cited by 260 publications

(174 citation statements)

References 24 publications

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“…These clinical applications confirmed the benefits of BGNs as a highly compatible graft in dentistry 60) . More recent applications of BGNs include several exemplar studies on doping therapeutic ions for accelerating hard tissue regeneration or coatings of hard tissue substitute with these nanocomposites 55,61) .…”

Section: Beneficial Effects Of Bioactive Glass Nanocomposites On Dentsupporting

confidence: 66%

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

2016

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Bioactive glass nanoparticles (BGNs) have been used over a range of dental tissue engineering. One main reason is possibly that BGNs strongly interact with hard tissues, while forming a stable interface after implantation. Recently, BGNs have been further diversified and ameliorated by incorporating bio-functional ions into BGNs or by functionally modifying the surface of BGNs. A comprehensive overview of the processes and applications of BGNs and their derivatives for the use in dentistry is thus necessary for their stepforward. Therefore, this review focuses on a variety of processes and practical applications of BGNs and their derivatives, which is expected to aid readerships with understanding and employing BGNs and their derivatives for personalized dental treatments.

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Section: Beneficial Effects Of Bioactive Glass Nanocomposites On Dentsupporting

confidence: 66%

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

2016

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“…[9,10] Based on the studies undertaken so far, these sol-gel glasses offer advantages over melt-derived glasses in several aspects. Firstly, the bioactivity of sol-gel glasses is maintained over a wider composition range (i.e., up to a higher silica content) than the melt-derived glasses.…”

Section: Introductionmentioning

confidence: 99%

Production and Potential of Bioactive Glass Nanofibers as a Next‐Generation Biomaterial

Kim

Knowles

2006

Adv Funct Materials

237

198

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Over the past decades, bioactive glass has played a central role in the bone regeneration field, due to its excellent bioactivity, osteoconductivity, and even osteoinductivity. Herein, exploitation of bioactive glass as a one‐dimensional nanoscale fiber by employing an electrospinning process based on a sol–gel precursor is reported for the first time. Under controlled processing conditions, continuous nanofibers have been generated successfully with variable diameters. The excellent bioactivity of the nanofiber is confirmed in vitro within a simulated body fluid by the rapid induction of bonelike minerals onto the nanofiber surface. The bone‐marrow‐derived cells are observed to attach and proliferate actively on the nanofiber mesh, and differentiate into osteoblastic cells with excellent osteogenic potential. The bioactive nanofibers have been further exploited in various forms, such as bundled filament, nanofibrous membrane, 3D macroporous scaffold, and nanocomposite with biopolymer, suggesting their versatility and potential applications in bone‐tissue engineering. Based on this study, the bioactive nanofibrous matrix is regarded as a promising next‐generation biomaterial in the bone‐regeneration field.

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“…Their surface reactivity makes them osteoconductivity when placed in bone tissue. 14 Bosetti et al 9 had investigated bioactivity of two different bioactive glass layers on zirconia substrate. They concluded that both bioactive glasses enhance zirconia integration with bone cells.…”

Section: Discussionmentioning

confidence: 99%

Response of MC3T3-E1cells on microroughen bioactive glass coated zirconia

Tuladhar¹,

Parajuli²,

Wang

2017

J Coll Med Sci-Nepal

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Background & Objectives:The objective of this study was to determine the cellular response of micro-roughened bioactive glass coated zirconia substrate (ZBR) and non roughen bioactive glass coated zirconia substrate (ZB), and compare them with uncoated zirconia substrate (Z). Materials & Methods: Surface micro-roughening was obtained using an Al2O3 sandblasting method. Abrasive blasting of zirconia coated bioactive glass produced an irregular finish with surface roughness average Ra 0.85 µm as determined by profilometer and scan electron microscope. Surface roughness of the samples in ascending order was ZBR>ZB>Z. Murine derived preosteoblast (MC3T3-E1) cells were seeded on the samples, and the cell morphology, growth, differentiation, were observed. Cell morphology was evaluated by means of scanning electron microscope (SEM), while cell proliferation and differentiation using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test and alkaline phosphates activity respectively. Results: The cell growth on all the samples continual increase with culturing up to 5days, showing good cell viability. However, there was no significant difference (p>0.05) with respect to the Z, ZB, and ZBR at day 5 at MTT assay. In particular, the alkaline phosphatase (ALP) activity of the cells was significantly higher on the ZB and ZBR than Z samples at both 7 and 14 days.Conclusion: Our findings demonstrate that bioactive glass coated surface was found to have better surface conditions to regulate bone cell differentiation

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Processing and properties of sol-gel bioactive glasses

Cited by 260 publications

References 24 publications

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

Bioactive glass-based nanocomposites for personalized dental tissue regeneration

Production and Potential of Bioactive Glass Nanofibers as a Next‐Generation Biomaterial

Response of MC3T3-E1cells on microroughen bioactive glass coated zirconia

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