Production and Potential of Bioactive Glass Nanofibers as a Next‐Generation Biomaterial

Kim, Hae‐Won; Kim, Hyoun‐Ee; Knowles, Jonathan C.

doi:10.1002/adfm.200500750

Cited by 237 publications

(204 citation statements)

References 20 publications

(23 reference statements)

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“…The second electrostatic force then also took part, enhancing fibre stretching and alignment. In the collector with gap (design 2-4), entangled and 02002-p. 2 …”

Section: Fibre Diameter and Morphologymentioning

confidence: 99%

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The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Anindyajati

Boughton

Ruys

2015

MATEC Web of Conferences

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Abstract. Electrospinning is a technique that can produce fibres in the nanoscale range. This process is useful for many applications, including fabrication of fibrous scaffolds for fibrocartilage tissue engineering. For this application, cell attachment and tissue development is influenced by fibre morphology and mechanical properties. This electrospinning study investigated the influence of rotating collector design on morphology and mechanical properties of electrospun polycaprolactone fibre. The experiment employed 4 mandrel designs: 1) full surface of aluminium; 2) with gap feature; 3) with gap feature and teflon support; 4) with gap feature and tape support. The highest elastic modulus was obtained from mandrel with gap and tape support, which was 24.6 MPa and significantly higher compared to fibres acquired from other collector designs. Fibre diameter attained was identical across the different collectors, ranging from 0.5 -2 µm. Gap introduction showed enhanced alignment in the resultant fibre. It can be concluded that fibre alignment and tensile properties can be improved by simply modifying the collector design. This improved fibre mat can be developed as a biomaterial for fibrocartilage tissue engineering scaffolds.

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“…The second electrostatic force then also took part, enhancing fibre stretching and alignment. In the collector with gap (design 2-4), entangled and 02002-p. 2 …”

Section: Fibre Diameter and Morphologymentioning

confidence: 99%

“…This technique can be applied in various materials and applications, including those in protective clothing, pharmaceutical, optical electronics, biosensors, environmental engineering, and tissue engineering [1][2][3][4]. The electrospinning process is driven by electrostatic force in the polymer solution.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Anindyajati

Boughton

Ruys

2015

MATEC Web of Conferences

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“…In recent years, considerable attention has been paid to the development of multifunctional fibrous matrices that combine cell-supporting and drug delivery capacities to promote tissue generation [1,2]. These matrices mimic the nanoscale features of an extracellular matrix to stimulate cell attachment and proliferation, while simultaneously providing active sites for the adsorption and release of various biological factors owing to their large surface-to-volume ratio [3].…”

Section: Introductionmentioning

confidence: 99%

BMP-2-loaded silica nanotube fibrous meshes for bone generation

Chen

Shi

Morita

et al. 2011

Science and Technology of Advanced Materials

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Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

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“…[19,20] More recently, electrospinning of sol-gel precursor was applied for the production of nanofibrous meshes of bioactive glass demonstrating their potential as a novel biomaterial for tissue engineering. [21,22] Herein we propose a new technique to produce nanofibers of bioactive glass in the form of intertwined disordered structures which may be used as scaffolds or as reinforcement in polymeric matrix composites: laser spinning. The results on the production of two different compositions of bioactive glass nanofibers by laser spinning are presented.…”

Section: Introductionmentioning

confidence: 99%

Laser Spinning of Bioactive Glass Nanofibers

Quintero

Pou

Comesaña

et al. 2009

Adv Funct Materials

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The production of nanofibers of bioactive glass by laser spinning is reported. The technique yields a great quantity of free-standing fibers in the form of a mesh of disordered intertwined fibers. The method does not rely on chemical processing and does not need any chemical additive. It involves melting of a precursor material with tailored composition, which makes it possible to produce nanofibers from materials with which conventional melt drawing techniques cannot be used. Herein, the production of 45S5 Bioglass® nanofibers is reported for the first time. The process is very fast (nanofibers of several centimeters are grown in a fraction of a second), without the necessity of post heat treatments, and no devitrification was observed as a result of 2 the laser spinning process. The morphology, composition and structure of the nanofibers were characterized and their bioactivity assessment was carried out by immersion in SBF. This technique provides a method for the rapid production of dense glass nanofibers which can be employed as bioactive nanocomposite reinforcement, as a synthetic bone graft to replace missing bone, or to produce 3D structures for use as scaffolds for bone tissue engineering.

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Production and Potential of Bioactive Glass Nanofibers as a Next‐Generation Biomaterial

Cited by 237 publications

References 20 publications

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

BMP-2-loaded silica nanotube fibrous meshes for bone generation

Laser Spinning of Bioactive Glass Nanofibers

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