Processing and nanomechanical properties of chitosan/polyethylene oxide blend films

Djokic, D Jelena; Kojović, Aleksandar; Stojanović, Dušica; Marinković, Aleksandar; Vuković, Goran D.; Aleksić, Radoslav; Uskoković, Dragan

doi:10.2298/jsc121121139d

Cited by 10 publications

(6 citation statements)

References 15 publications

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“…Translated to our work, the reduction of stiffness/ Young's modulus in lms with a higher PEO content (Fig. 6) is in good agreement with previous indentation 65 and uniaxial tensile test 66 measurements even if on a different scale. In addition, an elastic modulus of 9.46 MPa was measured for CH : PEO bers in ratio 1 : 1 with a spherical nanoindenter.…”

Section: Resultssupporting

confidence: 92%

“…Although our AFM analysis did not reveal any localized domains with distinctively dissimilar nanomechanical properties (thereby suggesting the absence of such spherulites), we cannot however exclude the existence of crystalline regions with a similar stiffness than that of the matrix. Based on these assumptions and our experimental data, we can only conclude that the amorphous/crystalline character of the electrodeposited blends likely depends on the PEO content, 14,18,65,74 but further experimental renements are required. It will be in fact necessary to resort to additional techniques (e.g.…”

Section: Resultsmentioning

confidence: 90%

“…The comparison of our results with the existing literature was not unequivocal because of the large variability in the published results. [64][65][66][67][68][69][70][71] In particular, the mechanical properties of chitosan not only depend on the sample preparation but also on the characterization method and on the scale at which the analysis is carried out. In this context, a correlation between measurements obtained with the same indenter at various scales (i.e.…”

Section: Resultsmentioning

confidence: 99%

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Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends

et al. 2015

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Cathodic electrodeposition is a bottom up process that is emerging as a simple yet efficient strategy to engineer thin polymeric films with well-defined physicochemical properties. In particular, this technique offers the distinctive advantage of an easy control over composition, thickness, and morphology of the films by simply adjusting treatment parameters. In this work, cathodic electrodeposition was exploited to engender blends composed by chitosan (CH) and poly-ethylene-oxide (PEO) with different weight ratios. The physicochemical and nanomechanical properties of the resulting films were successively characterized by integrating Raman and Fourier-transform infrared (FT-IR) spectroscopy with Atomic Force Microscopy (AFM). Our findings demonstrate that electro-deposition is an effective technique for the co-deposition of CH:PEO blends. Moreover, spectroscopic and AFM analyses correlated the physicochemical (i.e. structural organization, bond formation and cross-linking) and nanomechanical properties of the blends to the PEO content, ultimately unveiling the molecular interactions and mechanisms involved in the cathodic deposition of CH:PEO film

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

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Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends

et al. 2015

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“…In general, the Young's Modulus for fibrous matrices synthesized from PLGA as determined by nanoindentation methods has been found to be in the range of ~50 kPa [108]. Further it has also been reported that when chitosan is incorporated into polymer based scaffolds such as PEO, there is an increase in the Young's Modulus [109]. Polyacrylamide, polyethylene glycol as well as gels containing gelatin or hyaluronic acid have been shown to have Young's Modulus values in the range of 0.1 kPa at the lower end to 100 kPa at the higher end [110].…”

Section: Afm Imaging and Nanoindentation Analysismentioning

confidence: 99%

Comparison of Engineered Peptide-Glycosaminoglycan Microfibrous Hybrid Scaffolds for Potential Applications in Cartilage Tissue Regeneration

Romanelli

Knoll

Santora

et al. 2015

Fibers

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Advances in tissue engineering have enabled the ability to design and fabricate biomaterials at the nanoscale that can actively mimic the natural cellular environment of host tissue. Of all tissues, cartilage remains difficult to regenerate due to its avascular nature. Herein we have developed two new hybrid polypeptide-glycosaminoglycan microfibrous scaffold constructs and compared their abilities to stimulate cell adhesion, proliferation, sulfated proteoglycan synthesis and soluble collagen synthesis when seeded with chondrocytes. Both constructs were designed utilizing self-assembled Fmoc-protected valyl cetylamide nanofibrous templates. The peptide components of the constructs were varied. For Construct I a short segment of dentin sialophosphoprotein followed by Type I collagen were attached to the templates using the layer-by-layer approach. For Construct II, a short peptide segment derived from the integrin subunit of Type II collagen binding protein expressed by chondrocytes was attached to the templates followed by Type II collagen. To both constructs, we then attached the natural polymer N-acetyl glucosamine, chitosan. Subsequently, the glycosaminoglycan chondroitin sulfate was then attached as the final layer. The scaffolds were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), atomic force microscopy and scanning electron microscopy. In vitro culture studies were carried out in the presence of chondrocyte cells for OPEN ACCESSFibers 2015, 3 266 both scaffolds and growth morphology was determined through optical microscopy and scanning electron microscopy taken at different magnifications at various days of culture. Cell proliferation studies indicated that while both constructs were biocompatible and supported the growth and adhesion of chondrocytes, Construct II stimulated cell adhesion at higher rates and resulted in the formation of three dimensional cell-scaffold matrices within 24 h. Proteoglycan synthesis, a hallmark of chondrocyte cell differentiation, was also higher for Construct II compared to Construct I. Soluble collagen synthesis was also found to be higher for Construct II. The results of the above studies suggest that scaffolds designed from Construct II be superior for potential applications in cartilage tissue regeneration. The peptide components of the constructs play an important role not only in the mechanical properties in developing the scaffolds but also control cell adhesion, collagen synthesis and proteoglycan synthesis capabilities.

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“…Hence, addition of other polymers is necessary to obtain films with improved strength and elasticity [2] . Polymers such as polyethylene oxide [9,10] , Eudragit [11] , and polylactic acid [12] are used for this purpose. Eudragit RL is a water-insoluble derivative of acrylate polymers with widespread use in pharmaceutical dosage forms [11] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Mechanical Properties and Drug Permeability of Chitosan/Eudragit RL Composite Film

Kouchak

Handali

Boroujeni

2015

Osong Public Health and Research Perspectives

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ObjectivesThe aim of this study was to design and evaluate a chitosan-based film that has properties required for successful wound dressing, and can control drug penetration and maintenance time in the location.MethodsSeveral formulations of a film containing chitosan (3%) and different concentrations of Eudragit RL (0.5%, 1%, and 1.5%) were prepared using the casting/solvent evaporating technique. Mechanical properties, water vapor transmission rate (WVTR), oxygen permeability, water uptake, and nitrofurazone permeability through the films were investigated.ResultsThe study results showed that by increasing the Eudragit RL content of composite films, their thickness and tensile strength were enhanced, while their elongation was decreased. No significant difference was observed between the oxygen permeability, WVTR, and water uptake results of pure chitosan films and different composite films containing Eudragit RL. Nitrofurazone permeability of chitosan films was increased by the inclusion of Eudragit RL in composite films, while by increasing the concentration of Eudragit RL, the permeation rate of drug was decreased.ConclusionIn conclusion, addition of Eudragit RL can improve mechanical properties of chitosan films without any undesirable effect on their water uptake, oxygen permeability, and WVTR qualities. The permeation rate of drugs through the composite films can be modified by changing Eudragit RL/chitosan ratio.

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Processing and nanomechanical properties of chitosan/polyethylene oxide blend films

Cited by 10 publications

References 15 publications

Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends

Physicochemical and nanomechanical investigation of electrodeposited chitosan:PEO blends

Comparison of Engineered Peptide-Glycosaminoglycan Microfibrous Hybrid Scaffolds for Potential Applications in Cartilage Tissue Regeneration

Evaluation of the Mechanical Properties and Drug Permeability of Chitosan/Eudragit RL Composite Film

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