Processing and antibacterial application of biodegradable sponge nano-composite materials of silver nanoparticles and silk sericin

Boonpavanitchakul, Kanittha; Pimpha, Nuttaporn; Magaraphan, Rathanawan

doi:10.1016/j.eurpolymj.2020.109649

Cited by 21 publications

(11 citation statements)

References 30 publications

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“…Suppression of tumor growth in vivo was 70% higher in mice-model treated with micelles in comparison to control [ 84 ] Sericin-cholesterol-folate nano micelles IR780 Self-assembly DM: 140 nm Cancerous cells (Human papillomavirus-related endocervical adenocarcinoma, BGC-823) containing folate receptors efficiently internalized the nanoparticles, which results in cell toxicity after laser irradiation at 808 nm [ 85 ] Sericin nanoparticles Curcumin Desolvation method DM: 278.15 ± 53 nm; ZP: -23.0 ± 3.59 mV; PDI: 0.54 ± 0.09 The best nanoparticle physicochemical characteristic was achieved with 1 mg.mL −1 of sericin, which results in 84.7% of encapsulation entrapment [ 86 ] Sericin nanoparticles coated or not with poly-L-Lysine - Desolvation method DM: 16 to 156 nm; ZP: -34 to + 36.2 mV; PDI: 0.8 to 1 NPs produced with sericin (30–50 kDa) positively charged showed the strongest antibacterial effects in S. aureus and E. coli strains by enhancing ROS production [ 60 ] Sponge nanocomposite of sericin-silver nanoparticles - Green reduction using sericin as reductant DM: 111.1 to 175 nm Both nanoparticles and sponge nanocomposites induced antibacterial activity against S. aureus and E. coli. Antibacterial activity of sponge nanocomposites was concentration-dependent, being the best results achieved at 100 ppm of AgNPs [ 87 ] MD mean diameter, ZP Zeta potential, PDI polydispersity index …”

Section: Ser Nanoformulations: Biomedical and Pharmacological Propertmentioning

confidence: 99%

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

et al. 2021

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Background The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials. Main body Sericin (SER) is a protein mainly composed of glycine, serine, aspartic acid, and threonine amino acids removed from the silkworm cocoon (particularly Bombyx mori and other species). SER is a biocompatible material with economic viability, which can be easily functionalized due to its potential crosslink reactions. Also, SER has inherent biological properties, which makes possible its use as a component of pharmaceutical formulations with several biomedical applications, such as anti-tumor, antimicrobials, antioxidants and as scaffolds for tissue repair as well as participating in molecular mechanisms attributed to the regulation of transcription factors, reduction of inflammatory signaling molecules, stimulation of apoptosis, migration, and proliferation of mesenchymal cells. Conclusion In this review, the recent innovations on SER-based nano-medicines (nanoparticles, micelles, films, hydrogels, and their hybrid systems) and their contributions for non-conventional therapies are discussed considering different molecular mechanisms for promoting their therapeutic applications.

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Section: Ser Nanoformulations: Biomedical and Pharmacological Propertmentioning

confidence: 99%

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

et al. 2021

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“…Moreover, PVC replacement causes pain on patients and increases treatment costs [58]. A biodegradable water absorption sponge incorporating AgNP had antibacterial properties [59]. Likewise, FN-AgNP nanocomposites can become a novel of surface modification biomaterials for clinical treatments.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Fibronectin-AgNP for Regulation of Biological Performance and Endothelial Differentiation Ability of Mesenchymal Stem Cells

Hung

Chang

Tang

et al. 2021

IJMS

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The engineering of vascular regeneration still involves barriers that need to be conquered. In the current study, a novel nanocomposite comprising of fibronectin (denoted as FN) and a small amount of silver nanoparticles (AgNP, ~15.1, ~30.2 or ~75.5 ppm) was developed and its biological function and biocompatibility in Wharton’s jelly-derived mesenchymal stem cells (MSCs) and rat models was investigated. The surface morphology as well as chemical composition for pure FN and the FN-AgNP nanocomposites incorporating various amounts of AgNP were firstly characterized by atomic force microscopy (AFM), UV-Visible spectroscopy (UV-Vis), and Fourier-transform infrared spectroscopy (FTIR). Among the nanocomposites, FN-AgNP with 30.2 ppm silver nanoparticles demonstrated the best biocompatibility as assessed through intracellular ROS production, proliferation of MSCs, and monocytes activation. The expression levels of pro-inflammatory cytokines, TNF-α, IL-1β, and IL-6, were also examined. FN-AgNP 30.2 ppm significantly inhibited pro-inflammatory cytokine expression compared to other materials, indicating superior performance of anti-immune response. Mechanistically, FN-AgNP 30.2 ppm significantly induced greater expression of vascular endothelial growth factor (VEGF) and stromal-cell derived factor-1 alpha (SDF-1α) and promoted the migration of MSCs through matrix metalloproteinase (MMP) signaling pathway. Besides, in vitro and in vivo studies indicated that FN-AgNP 30.2 ppm stimulated greater protein expressions of CD31 and von Willebrand Factor (vWF) as well as facilitated better endothelialization capacity than other materials. Furthermore, the histological tissue examination revealed the lowest capsule formation and collagen deposition in rat subcutaneous implantation of FN-AgNP 30.2 ppm. In conclusion, FN-AgNP nanocomposites may facilitate the migration and proliferation of MSCs, induce endothelial cell differentiation, and attenuate immune response. These finding also suggests that FN-AgNP may be a potential anti-inflammatory surface modification strategy for vascular biomaterials.

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“…Its is biocompatible, biodegradable, nonimmunogenic, and possesses cell-adhesion, antiapoptosis, and cytoprotective properties. 81 Because of its amorphous nature, sericin has poor mechanical strength and lacks antibacterial activity. The use of antibacterial inorganic nanoparticles along with polymeric agents enhance the properties of sericin.…”

Section: Biosynthesis Of Nanoparticlesmentioning

confidence: 99%

“…It is also extracted from the silkworm cocoon. Its is biocompatible, biodegradable, nonimmunogenic, and possesses cell-adhesion, antiapoptosis, and cytoprotective properties . Because of its amorphous nature, sericin has poor mechanical strength and lacks antibacterial activity.…”

Section: Biosynthesis Of Nanoparticlesmentioning

confidence: 99%

Biofabricated Nanostructures and Their Composites in Regenerative Medicine

Makvandi

Ghomi

Padil

et al. 2020

ACS Appl. Nano Mater.

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Biosynthesis of nanomaterials is gaining attention as a sustainable, environmentally friendly, and reliable method for manufacturing a extensive array of nanostructures, such as metal/metal oxides and organic and hybrid materials. Green synthesis is considered a crucial tool to reduce the harsh effects associated with conventional synthesis. Nanocomposite materials containing biosynthesized nanostructures are highly sought after in regenerative medicine. In the present Review, biosynthesis of metal/metal oxides and carbon-based nanomaterials using microorganisms (e.g., bacteria and fungi) and natural compounds (e.g., polysaccharides, proteins, fruit juices, and plant extracts) is highlighted. The toxicity of biosynthesized nanoparticles for biomedical application is also reviewed in depth. The applications of bionanocomposites prepared from these ecofriendly nanoparticles in tissue engineering are reviewed to provide readers with a background for future studies.

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Processing and antibacterial application of biodegradable sponge nano-composite materials of silver nanoparticles and silk sericin

Cited by 21 publications

References 30 publications

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

Sericin based nanoformulations: a comprehensive review on molecular mechanisms of interaction with organisms to biological applications

Anti-Inflammatory Fibronectin-AgNP for Regulation of Biological Performance and Endothelial Differentiation Ability of Mesenchymal Stem Cells

Biofabricated Nanostructures and Their Composites in Regenerative Medicine

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