Processes of drug transfer with three different polymeric systems with transdermal drug delivery

Ouriemchi, E. M.; Vergnaud, J.M.

doi:10.1016/s1089-3156(00)00003-9

Cited by 24 publications

(12 citation statements)

References 25 publications

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“…Often the transport mechanism in this type of systems does not behave according to Fickian diffusion. In fact, the results obtained in experimental context support the previous sentence ( [6], [10], [25], [31], [33], [34], [36], [37], see also [35] and the references contained in the last paper). However, often we find in the literature mathematical models for percutaneous drug absorption considering the system vehicle-skin established by using Fick's law (see e.g.…”

supporting

confidence: 87%

Coupled vehicle–skin models for drug release

Barbeiro

Ferreira

2009

Computer Methods in Applied Mechanics and Engineering

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Please cite this article as: S. Barbeiro, J.A. Ferreira, Coupled vehicle-skin models for drug release, Comput. Methods Appl. Mech. Engrg. (2009), doi: 10.1016/j.cma.2009 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. ACCEPTED MANUSCRIPT AbstractPercutaneous absorption of a drug delivered by a vehicle source is usually modeled by using diffusion Fick's law. In this case, the model consists in a system of partial differential equations of diffusion type with a compatibility condition on the transition boundary between the vehicle and the skin. Using this model, the fractional drug release in both componentsvehicle and skin -is proportional to the square root of the release time. Often experimental results show that the predicted drug concentration distribution in the vehicle and in the skin by the Fick's model does not agree with experimental data. In this paper we present a nonFickian mathematical model for the introduced percutaneous absorption problem. In this new model the Fick's law for the flux is modified by introducing a non-Fickian contribution defined with a relaxation parameter related to the properties of the components. Combining the flux equation with the mass conservation law, a system of integro-differential equations is established with a compatibility condition on the boundary between the two components of the physical model. The stability analysis is presented. In order to simulate the mathematical model, its discrete version is introduced. The stability and convergence properties of the discrete system are studied. Numerical experiments are also included.

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supporting

confidence: 87%

Coupled vehicle–skin models for drug release

Barbeiro

Ferreira

2009

Computer Methods in Applied Mechanics and Engineering

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“…(3) is corresponding to the first hypothesis , which indicate a constant surface drug concentration. (4) shows the sink condition at the inside of skin. As the drug molecules arrive, it will be absorbed by the capillaries in the subcutaneous tissue.…”

Section: *Corresponding Author School Of Control Science and Engineementioning

confidence: 99%

“…E.M.Ouriemchi and J.M.Vergnaud discussed the systems structure and the drug release methods of three TTS's. And they analyzed the different diffusion properties of the drug in the skin [4]. Traditional transdermal drug delivery models were generally considered to be steady-state processes, of which the initial concentration was 0.William J.A ddicks changed this condition, assuming initial drug concentrations in the skin was in balance with surface drug concentration , thereby to get the concentration profiles in the skin [5].…”

Section: Introductionmentioning

confidence: 99%

Notice of Retraction: Analysis of the Properties of Transdermal Drug Delivery with Constant Surface Drug Concentration

Chen

Wei

Zhang

2011

2011 5th International Conference on Bioinformatics and Biomedical Engineering

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Objective: To build a mathematical model of percutaneous drug delivery, then solve it with appropriate initial conditions and boundary conditions to get the concentration profile of drugs in the skin. Methods: Based on the three-step percutaneous penetration model and Fick's law of diffusion, build a mathematical model , analyze the factors which affect the process of diffusion. Results: By mathematical analysis, we get the drug concentration profiles in the skin layer at different time and the characteristic curves of drug penetration performance. Diffusion and absorption properties of drug under different surface drug concentration and diffusion coefficients are also given. Conclusion: Increasing the diffusion coefficient within a certain range can effectively accelerate the drug diffusion and absorption. Surface drug concentration has a small impact on the diffusion rate, but it can significantly promote the absorption process in subcutaneous tissue. Therefore, appropriately increasing skin diffusion coefficient and surface drug concentration is the main purpose of different enhancing osmosis methods.

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“…An ideal porous scaffold has a specific pore size with greater porosity and an appropriate surface-to-volume ratio that enables diffusion of the nutrients, drug, etc. [57,58]. Some of the synthetic biodegradable polymers used as porous scaffolding materials include poly-ethylene glycol (PEG), poly(lactic acid) (PLA), polyglycolide (PGA), poly(lactic- co -glycolic acid) (PLGA) [56], polycaprolactone (PCL) [59], poly( d , l -lactic acid or d , l -lactide) (PDLLA), polyester elastomer (PEE) based on polyethylene oxide (PEO), and Polybutylene terephthalate (PBT) [28].…”

Section: Scaffolding Approaches and Different Types Of Scaffolds Imentioning

confidence: 99%

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

Chaudhari

Vig

Baganizi

et al. 2016

IJMS

454

288

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Over centuries, the field of regenerative skin tissue engineering has had several advancements to facilitate faster wound healing and thereby restoration of skin. Skin tissue regeneration is mainly based on the use of suitable scaffold matrices. There are several scaffold types, such as porous, fibrous, microsphere, hydrogel, composite and acellular, etc., with discrete advantages and disadvantages. These scaffolds are either made up of highly biocompatible natural biomaterials, such as collagen, chitosan, etc., or synthetic materials, such as polycaprolactone (PCL), and poly-ethylene-glycol (PEG), etc. Composite scaffolds, which are a combination of natural or synthetic biomaterials, are highly biocompatible with improved tensile strength for effective skin tissue regeneration. Appropriate knowledge of the properties, advantages and disadvantages of various biomaterials and scaffolds will accelerate the production of suitable scaffolds for skin tissue regeneration applications. At the same time, emphasis on some of the leading challenges in the field of skin tissue engineering, such as cell interaction with scaffolds, faster cellular proliferation/differentiation, and vascularization of engineered tissues, is inevitable. In this review, we discuss various types of scaffolding approaches and biomaterials used in the field of skin tissue engineering and more importantly their future prospects in skin tissue regeneration efforts.

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Processes of drug transfer with three different polymeric systems with transdermal drug delivery

Cited by 24 publications

References 25 publications

Coupled vehicle–skin models for drug release

Coupled vehicle–skin models for drug release

Notice of Retraction: Analysis of the Properties of Transdermal Drug Delivery with Constant Surface Drug Concentration

Future Prospects for Scaffolding Methods and Biomaterials in Skin Tissue Engineering: A Review

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