Abstract:Objective: To build a mathematical model of percutaneous drug delivery, then solve it with appropriate initial conditions and boundary conditions to get the concentration profile of drugs in the skin. Methods: Based on the three-step percutaneous penetration model and Fick's law of diffusion, build a mathematical model , analyze the factors which affect the process of diffusion. Results: By mathematical analysis, we get the drug concentration profiles in the skin layer at different time and the characteristic … Show more
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