Process optimization for microwave assisted extraction of Foeniculum vulgare Mill using response surface methodology

Akhtar, Iqra; Javad, Sumera; Ansari, Madeeha; Ghaffar, Nadia; Tariq, Amina

doi:10.1016/j.jksus.2019.11.041

Cited by 18 publications

(9 citation statements)

References 16 publications

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“…Therefore, an alternative method, viz., microwave-assisted extraction (MAE), is more suitable. MAE has been proven to effectively extract different types of compounds in a wide variety of edible flowers and plant parts [15][16][17][18][19]. The extraction rate is enhanced by a unique direct energy transference offered by MAE.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Extraction of Phenolics from Hibiscus sabdariffa Flowers: Method Development and Validation

Fathimah¹,

Setyaningsih²,

Carrera³

et al. 2020

The 1st International Electronic Conference on Food Science and Functional Foods

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Phenolics are bioactive compounds already reported in Hibiscus sabdariffa (roselle). The present study reports the development and validation of the analytical microwave-assisted extraction (MAE) method for the determination of phenolic compounds in roselle flowers to establish their positive contribution to human health. Prior to the optimization, a study for identifying phenolic compounds revealed that chlorogenic acid, protocatechuic acid, caffeic acid, and rutin were presented in Roselle. Three factors affecting MAE, viz. temperature, solvent composition, and sample to solvent ratio, were optimized employing a Box-Behnken Design (BBD) in conjunction with response surface methodology (RSM). The maximum extraction recovery was achieved using the extraction temperature of 68 °C, solvent composition of 59% MeOH in water, and 20:1 solvent to sample ratio. The kinetics experiment confirmed full recoveries (92–119%) at 15 min. Subsequently, method validation showed a satisfactory result, including low detection limits from 0.219 mg L−1 (caffeic acid) to 0.374 mg L−1 (chlorogenic acid). Both precisions and accuracy met the acceptances by AOAC. Finally, the method was successfully applied to quantify phenolics in the two most common varieties of Roselle. Chlorogenic acid was found as the main phenolic compound in both varieties

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Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Extraction of Phenolics from Hibiscus sabdariffa Flowers: Method Development and Validation

Fathimah¹,

Setyaningsih²,

Carrera³

et al. 2020

The 1st International Electronic Conference on Food Science and Functional Foods

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“…Conventional extraction methods for capsinoids suffer from several drawbacks which include low product yields and high solvent consumption. In addition, these extraction techniques are complicated and time-consuming and the low extraction yields lead to waste material which is a health hazard to personnel and deleterious to the environment. , Such factors have led to intense study to design alternative extraction methods aimed at reducing solvent consumption, decreasing the time of extraction, and diminishing the production of waste material. Among these emerging environment-friendly technologies, microwave-assisted extraction (MAE) has proven to be an excellent approach to obtaining high yields of capsinoids from chili peppers. , MAE has several advantages over conventional extraction techniques that includes shorter extraction times, lower solvent consumption, higher extraction efficiency, and a decrease in the quantity of undesirable waste products.…”

Section: Isolation Of Region B Capsaicin Analogs From Natural Sourcesmentioning

confidence: 99%

“…peppers 45,51. MAE has several advantages over conventional extraction techniques that includes shorter extraction times, lower solvent consumption, higher extraction efficiency, and a decrease in the quantity of undesirable waste products.…”

mentioning

confidence: 99%

Anticancer Activity of Region B Capsaicin Analogs

et al. 2023

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The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses the growth of multiple human cancers. Apart from capsaicin, natural and synthetic capsaicin-like compounds display growth suppressive activity in human cancers. The pharmacophore of capsaicin is comprised of three regions, namely region A (the aromatic ring), region B (the amide bond), and region C (the side chain). The present manuscript describes the isolation and synthesis of capsaicin analogs which have structural modifications in region B of the molecule. Furthermore, the pharmacokinetic properties, anticancer activity of region B capsaicin analogs, as well as the signaling pathways (underlying the growth-inhibitory effects of region B capsaicin analogs) have also been described. The discovery of novel, second-generation region B capsaicin analogs may foster the hope of innovative nutrition-based combination therapies in human cancers.

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“…Fennel (Foeniculum vulgare Mill.) is a biennial medicinal and aromatic plant from the Apiaceae family [1], widespread in the Mediterranean area and known for its yellow flowers grouped in umbels, feathery leaves, hollow stem and aromatic seeds. Along with traditional use for culinary purposes and flavoring, due to its beneficial effects on human health the plant is widely used in traditional medicine to relieve colic in infants, to relieve respiratory and gastrointestinal disorders, and to prevent various diseases caused by oxidative stress-cancer, cardiovascular diseases, inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Scientific interest in fennel seeds has been largely focused on their essential oils [17][18][19][20][21], applying advanced extraction techniques such as supercritical fluid extraction [22][23][24], while published research on the isolation of phenolic compounds from fennel seeds, especially the comparison of different extraction techniques and applied extraction conditions, is quite limited. Recently, only the study by Akhtar et al (2020) [1] compared MAE with conventional Soxhlet and cold maceration extraction techniques and optimized MAE using water as an extraction solvent. MAE proved to be an energy efficient and rapid method for the isolation of phytochemicals from fennel seeds, giving higher extraction yields when compared to the applied conventional techniques.…”

Section: Introductionmentioning

confidence: 99%

Phenolic Characterization and Bioactivity of Fennel Seed (Foeniculum vulgare Mill.) Extracts Isolated by Microwave-Assisted and Conventional Extraction

et al. 2022

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The aim of this study was to evaluate the effectiveness of microwave-assisted extraction (MAE) as an environmentally friendly approach compared to conventional heat-reflux extraction (CE) for the isolation of fennel (Foeniculum vulgare Mill.) seed polyphenols and to assess the bioactivity of the obtained extracts. Water, ethanol (30%, v/v) and acetone (30%, v/v) were used as extraction solvents, and the extraction was carried out varying the temperature (40, 60 and 80 °C), irradiation time (5 and 10 min) and microwave power (300 and 600 W). According to the total phenolic content (TPC), 30% acetone at 80 °C after 5 min of irradiation at 300 W proved to be the optimal MAE conditions for obtaining the highest yield of polyphenols. The phenolic profile of both extracts comprised 21 compounds, with cinnamic acids and flavonols being the most abundant. When compared to CE, the MAE extract showed a lower amount of TPC as well as the sum of all identified individual phenols, although both extracts showed similar antioxidant capacity. The antimicrobial activity of the extract with the highest phenolic content was weak, showing inhibitory activity only against Pseudomonas fragi, Shewanella putrefaciens and Campylobacter jejuni strains, while Gram-positive bacteria and yeasts were not sensitive to the extract.

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Process optimization for microwave assisted extraction of Foeniculum vulgare Mill using response surface methodology

Cited by 18 publications

References 16 publications

Microwave-Assisted Extraction of Phenolics from Hibiscus sabdariffa Flowers: Method Development and Validation

Microwave-Assisted Extraction of Phenolics from Hibiscus sabdariffa Flowers: Method Development and Validation

Anticancer Activity of Region B Capsaicin Analogs

Phenolic Characterization and Bioactivity of Fennel Seed (Foeniculum vulgare Mill.) Extracts Isolated by Microwave-Assisted and Conventional Extraction

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