Process Optimization, Characterization, and Release Study In Vitro of an Intravenous Puerarin Lipid Micropheres Loaded with the Phospholipid Complex

Process optimization and evaluation of novel baicalin solid nanocrystals

“…A statistical model with interactive and polynomial terms was used to evaluate the response values using the formula 24 :…”

Engineering of a novel optimized platform for sublingual delivery with novel characterization tools: in vitro evaluation and in vivo pharmacokinetics study in human

“…MSP-PLCP were prepared by employing the solvent-evaporation method (Yanyu et al., 2006 ; Maiti et al., 2007 ; Yue et al., 2010 ; Yue et al., 2010 ; Cai et al., 2012 ; Guo et al., 2014 ; Singh et al., 2014 ; Kassem et al., 2017 ; Jena et al., 2014 ; Cheng et al., 2015 ; Khurana et al., 2017 ). Briefly, weighed amounts of MSP and PLs were refluxed in a 100-ml rounded bottom flask containing tetrahydrofuran as reaction solvent at 60 °C for 2 h. Tetrahydrofuran was then evaporated off under vacuum at 40 °C.…”

“…During this study, one of these approaches was used. This approach depends on weak physical interaction by hydrogen bond formation and electrostatic interaction between drug molecule and phospholipids to form drug–phospholipid complex (Yanyu et al., 2006 ; Maiti et al., 2007 ; Yue et al., 2010 ; Yue et al., 2010 ; Cai et al., 2012 ; Guo et al., 2014 ; Singh et al., 2014 ). The prepared drug–phospholipid complex is then formulated into a flushing resistance platform with the addition of a mucoadhesive polymer.…”