Phospholipid complexation: A versatile technique for delivery of phytomedicine

Biswas, Sayan; Kar, Amit; Sharma, Nanaocha; Haldar, Pallab Kanti

doi:10.1016/b978-0-323-85542-6.00019-6

Cited by 5 publications

(2 citation statements)

References 137 publications

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“…Phospholipid complexation promotes the solubility of the drug, and facilitates its penetration into the body, as well as its sustained release. One of the most important advantages of the formed phospholipid complexes is that they are biocompatible (their main ingredient is usually phosphatidylcholine); therefore, their side effects are weak or absent [66].…”

Section: Individual Sterol Tocopherol and Phospholipid Composition Of...mentioning

confidence: 99%

Ailanthus altissima Seed Oil—A Valuable Source of Lipid-Soluble Components with DNA Protective and Antiproliferative Activities

Andonova,

Petkova,

Teneva

et al. 2024

Foods

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The present study is focused on the chemical and lipid composition of seed oil of the European ornamental and invasive wood plant Ailanthus altissima (Simaroubaceae). Total lipids, proteins, carbohydrates, ash, and moisture in the seeds were determined. A high yield of glyceride oil (30.7%) was found, as well as a high content of fibers (29.6%) and proteins (18.7%). Physicochemical properties of the oil define it as semi-dry (129.4 g I2/100 g Iodine value) with oxidative stability, refractive index, saponification value, and relative density similar to widely used oils with nutritional value and health benefits. The composition of the seed oil was determined chromatographically. Unsaturated fatty acids (95.3%) predominated in the seed oil, of which linoleic acid (48.6%) and oleic acid (44.8%) were the major ones. The main lipid-soluble bioactive components were β-sitosterol (72.6%), γ-tocopherol (74.6%), phosphatidylinositol (29.5%), and phosphatidic acids (25.7%). The proven in vitro DNA-protective ability of seed oil is reported for the first time. The seed oil exhibited a weak antiproliferative effect on HT-29 and PC3 tumor cell lines and showed no cytotoxicity on the BALB/c 3T3 cell line. In brief, the present study reveals that A. altissima seed oil can be used as a healthy food.

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Section: Individual Sterol Tocopherol and Phospholipid Composition Of...mentioning

confidence: 99%

Ailanthus altissima Seed Oil—A Valuable Source of Lipid-Soluble Components with DNA Protective and Antiproliferative Activities

Andonova,

Petkova,

Teneva

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…They can increasingly penetrate through the skin and, when applied locally, enhance the effectiveness of the active components. In addition, the formed phospholipid complexes are more stable compared to other lipids, which guarantees their stability and facilitates the preparation of substances for the treatment of various diseases [69].…”

Section: Chemical Composition and Physicochemical Characteristics Of ...mentioning

confidence: 99%

Koelreuteria paniculata Seed Oil—A Rich Natural Source of Unsaturated Fatty Acids and Phytocompounds with DNA Protective Potential

Andonova

Muhovski

Apostolova

et al. 2023

Foods

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The present work is focused on the physicochemical characteristics, chemical composition, and some biological activities of Koelreuteria paniculata seed oil. The glyceride oil, obtained with a Soxhlet apparatus by extraction with hexane, was characterized by a relatively high oil content (over 20%), and it is defined as a non-drying oil (iodine value—44 gI2/100 g) with good oxidative stability (over 50 h). There were identified 11 fatty acids, 6 sterols, 3 tocopherols, and 6 phospholipids, as the last group was reported for the first time. The major components among them were—monounsaturated eicosenoic and oleic acids, β-sitosterol, β-tocopherol, and phosphatidylcholine. The in vitro tests demonstrated DNA protective activity and a lack of cytotoxicity of the oil, data that has been reported for the first time. The in vitro MTT test of the oil on HT-29 and PC3 cell lines did not indicate antitumor activity. The seed oil studied contains valuable bio-components, which have proven benefits for human health, and that is why it could be used in food, cosmetic, and pharmaceutical products.

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Deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis of pineapple biomass via Response Surface Methodology

Roslan,

Luthfi,

Salleh

et al. 2024

Biomass Conv. Bioref.

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Phospholipid complexation: A versatile technique for delivery of phytomedicine

Cited by 5 publications

References 137 publications

Ailanthus altissima Seed Oil—A Valuable Source of Lipid-Soluble Components with DNA Protective and Antiproliferative Activities

Ailanthus altissima Seed Oil—A Valuable Source of Lipid-Soluble Components with DNA Protective and Antiproliferative Activities

Koelreuteria paniculata Seed Oil—A Rich Natural Source of Unsaturated Fatty Acids and Phytocompounds with DNA Protective Potential

Deep eutectic solvent pretreatment for enhanced enzymatic hydrolysis of pineapple biomass via Response Surface Methodology

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