“…Taking advantage of the conditionally immortalized cell line (Mundel et al, 1997a; kindly provided by Dr Mundel, Albert Einstein College of Medicine, NY, USA), we have also shown the contribution of PP2A-driven dephosphorylation in podocytes. Like in neurons (Chiou & Westhead, 1992), application of okadaic acid at nanomolar concentrations, which preferentially inhibits PP2A and, in turn, elevates the level of protein Ser/ Thr phosphorylation, resulted in the total abolition of the formation of podocyte process, accompanied by an increase in protein Ser/Thr phosphorylation (Kobayashi et al, 2001b) and a decrease in MT stability detected by post-translational modification of tubulin (Gao et al, 2004). Conversely, inhibition of various Ser /Thr kinases enhanced process formation of podocytes ( Fig.…”