Abstract:Insect nephrocytes provide a valuable model for kidney disease, as they are structurally and functionally homologous to mammalian kidney podocytes. They possess an exceptional macromolecular assembly, the nephrocyte diaphragm (ND), which serves as a filtration barrier and helps maintain tissue homeostasis by filtering out wastes and toxic products. However, the nephrocyte architecture and elements that maintain the ND are not understood. We show that Drosophila nephrocytes have a unique cytoplasmic cluster of … Show more
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