Process control and scale-up of modified bacterial cellulose production for tailor-made anti-inflammatory drug delivery systems

Bacterial nanocellulose as a corneal bandage material: a comparison with amniotic membrane

“…This can be achieved by mechanically increasing fibre alignment 46 or by filling the pores with biocompatible polymers such as polyethylene glycol. 40 Importantly, we validate that BNC can be sutured to the ocular surface without employing more time or resources than AM while presenting a higher resistance to the mechanical stress caused by the suture. Moreover, its soft and flexible nature confers optimal adaptability to the dome shape of the ocular surface.…”

“…That is, BNC hydrogels are expect to be neither pro nor anti-inflammatory as demonstrated in ref. 40 with in vitro tests. It has also been argued that BNC is well tolerated in vivo without causing major inflammatory complications.…”

“…In fact, the anti-inflammatory effect BNC hydrogels supplemented with diclofenac has recently been reported. 40 Similarly, in cases of bacterial keratitis, BNC could be impregnated with antibiotics to act as a medication reservoir. In this direction, BNC is also well known to support the culture of several cell types [50][51][52] including retinal pigment epithelial cells.…”

In vivosoft tissue reinforcement with bacterial nanocellulose

“…Before that, we characterized the BNC patches and present an increased BNC production (up to ∼1 m 2 ) under laboratory settings to illustrate the feasibility of an up-scaled fabrication. However, to achieve an industrial manufacturing process, a more advanced system should be implemented such as the pilot-scale production processes reported by Kralisch et al 35 and Beekmann et al 36 The mechanical characterization of as-synthesized BNC films (wet films) and after drying showed that wet BNC patches are thicker, more brittle but more stretchable than dry BNC patches. This confers to the wet-BNC a higher strain but, at the same time, makes the material less resistant to tear.…”

Recent Advances in Antiinflammatory Material Design

“…[105] Recently, scale up production of BC hydrogels loaded with anti-inflammatory drug diclofenac was described. [106] In addition, the team investigated spray loading of diclofenac for reduction in loading time. These results are very promising for BC use as anti-inflammatory wound dressing at large scale.…”