Procaspase-3 Activating Therapeutic Agents in Cancer Therapy

Aziz, Gulzeb

doi:10.14737/journal.ape/2014/2.1.1.6

Adv. pharm. ethnomed.

2014

DOI: 10.14737/journal.ape/2014/2.1.1.6

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Procaspase-3 Activating Therapeutic Agents in Cancer Therapy

Gulzeb Aziz¹

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2016

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Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

et al. 2016

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Leukemia is among the most aggressive and prevalent human malignant carcinoma. Chemotherapy is the preferred therapeutic strategy; however, recurrence of cancer and non-selective cytotoxicity are the major concerns. Unlike synthetic chemotherapeutic agents, mistletoe ribosome-inactivating protein (RIP) displays anti-tumor function in various types of cancers. However, its effect on leukemia cells is little explored. In this study, we assessed the impact of Viscum articulatum RIP (Articulatin-D) on the survival of acute T-cell leukemia cells and the involved molecular and cellular mechanisms. Cell proliferation assay showed that Articulatin-D suppressed the viability of leukemia cells selectively. We further confirmed that the elevation of mitochondrial membrane potential and exposure of phosphatidylserine are the early events of apoptosis induction in Articulatin-D-treated Jurkat cells. Subsequently, we found that Articulatin-D treatment induces apoptosis in Jurkat cells in a time- and concentration-dependent manner. In conclusion, we provided evidence that Articulatin-D efficiently activates caspase-8 involved in extrinsic pathway of apoptosis induction, which ultimately results in caspase-3-dependent DNA fragmentation of Jurkat cells. Further evaluation of Articulatin-D in cell culture and animal models may provide novel information on selective cytotoxicity to acute T-cell leukemia and its involvement in targeting tumor cell survival pathways.

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Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

et al. 2016

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Procaspase-3 Activating Therapeutic Agents in Cancer Therapy

Cited by 1 publication

References 19 publications

Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

Articulatin-D induces apoptosis via activation of caspase-8 in acute T-cell leukemia cell line

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