Procalcitonin: diagnostic value in systemic infections in chronic kidney disease or renal transplant patients

Dumea, Raluca; Siriopol, Dimitrie; Hogaş, Simona; Mititiuc, Irina; Covic, Adrian

doi:10.1007/s11255-013-0542-8

Cited by 34 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In renal transplant children PCT had a higher sensitivity and specificity, compared to dialysis children. The best cutoff level for the diagnosis of infection for PCT was 0.441 ng/ml in our study, which is approximately similar to the common level [44]. However, these results are different from those previously published [45].…”

Section: Discussioncontrasting

confidence: 77%

Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

Fadel

Elshamaa

Elghoroury

et al. 2016

Arch Med Sci Atheroscler Dis

View full text Add to dashboard Cite

IntroductionSerum procalcitonin (PCT) levels are known to be low in healthy individuals in healthy subjects but are increased in patients with a severe bacterial infection. It has not been extensively studied in children with chronic kidney disease (CKD), treated either with hemodialysis (HD) or with renal transplantation.Material and methodsDuring a 6-month period, blood samples were taken from 102 (55 HD children and 47 renal transplant recipients) children with a strong clinical suspicion of infection. Procalcitonin levels were measured by ELISA.ResultsThirty-four/102 cases had proven infections as defined previously. Children with proven infections had a significantly higher PCT (0.920 ±0.24 ng/ml) than those without (0.456 ±0.53 ng/ml), p = 0.04. The ideal cutoff value derived for serum PCT was 0.5 ng/ml. This threshold value established a sensitivity of 94.1% and a specificity of 87.9%.ConclusionsThis study indicates that significantly increased PCT concentration is a promising predictor of systemic bacterial infection in children with CKD, with good sensitivity and specificity. This study proposes that serum PCT is a convenient index of infection in CKD children at a cutoff value of 0.5 ng/ml.

show abstract

Section: Discussioncontrasting

confidence: 77%

Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

Fadel

Elshamaa

Elghoroury

et al. 2016

Arch Med Sci Atheroscler Dis

View full text Add to dashboard Cite

show abstract

“…Whether PCT levels are affected by chronic immunosuppression has not been deeply investigated. Most published studies support the notion that chronic immunosuppression should not affect baseline PCT levels in the absence of infection . In a human model of endotoxemia, administration of oral prednisolone in doses up to 30 mg, two h before lipopolysaccharide infusion, did not affect PCT kinetics .…”

Section: Effects Of Chronic Immunosuppression On Pct Levelsmentioning

confidence: 79%

“… reported a peak PCT cutoff of 1.92 ng/mL as a predictor for infectious and non‐infectious complications with a sensitivity of 95.6% and specificity of 89.5%, although those who suffered complications had worse baseline characteristics and higher Child–Pugh scores. In a cohort of 82 patients with renal transplant and end‐stage renal disease, PCT > 0.5 ng/mL had a sensitivity of 78.6% and specificity of 85.7% in renal transplant recipients vs. 97.7% and 70%, respectively, in hemodialysis; this likely reflects a PCT release effect from the membranes used for dialysis . The amount of allograft‐associated lymphoid tissue that upregulates the inflammatory response or requires induction with lytic therapy might impact PCT levels; however, this does not limit the utility of PCT as diagnostic tool as PCT should be followed dynamically with serial measurements.…”

Section: Use Of Pct To Differentiate Infectious Vs Non‐infectious Symentioning

confidence: 99%

The use and value of procalcitonin in solid organ transplantation

Sandkovsky

Kalil

Florescu

2015

Clinical Transplantation

View full text Add to dashboard Cite

Procalcitonin (PCT) has been increasingly used as a biomarker of bacterial infection and as a tool to guide antimicrobial therapy, especially in lower respiratory tract and bloodstream infections. Despite its increased use, data in patients with solid organ transplants are limited. Even without the presence of infection, PCT increases as a result of surgical procedures during transplantation, implantation of devices, and use of induction immunosuppressive therapy. The risk of infection is also higher in solid organ transplant recipients when compared to the general population. Monitoring PCT in the early post-transplant period seems to be a promising method for early detection of infectious complications. It has been shown that elevated PCT levels after one wk of transplantation are correlated with infectious complications. PCT may be a useful adjunctive biomarker that may improve early identification and guide appropriate treatment of infection or rejection, with the potential to further improve clinical outcomes. The use of serial PCT measurements may be more reliable than single values. It is important to recognize which factors may lead to PCT increases in the post-transplantation period, which in turn will help understand the kinetics and utility of this biomarker in this important patient population.

show abstract

“…показано, что функцио-нальное состояние почек мало влияет на клиренс ПКТ и значения последнего в группах с хронической почечной недостаточностью и без таковой не отлича-лись [30]. Аналогичные результаты были получены при изучении уровня ПКТ у пациентов с почечной недостаточностью, находящихся на диализе, и реци-пиентов трансплантированной почки [31]. У этих больных пороговое значение ПКТ равнялось 0,59 нг / мл, что близко к общепринятому для популя-ции.…”

Section: системная красная волчанкаunclassified

Procalcitonin Testing in Rheumatology

Буханова¹,

Белов²,

Тарасова³

et al. 2017

Klinicist

View full text Add to dashboard Cite

Procalcitonin: diagnostic value in systemic infections in chronic kidney disease or renal transplant patients

Abstract: Our data indicate that significantly elevated PCT concentrations offer good sensitivity and specificity for the early diagnosis of systemic bacterial infection in patients with CKD.

Cited by 34 publications

References 33 publications

Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

Usefulness of serum procalcitonin as a diagnostic biomarker of infection in children with chronic kidney disease

The use and value of procalcitonin in solid organ transplantation

Procalcitonin Testing in Rheumatology

Contact Info

Product

Resources

About