Procalcitonin as marker of infection in patients with Goodpasture's syndrome is misleading

Morath, Christian; Sis, Jeanne; Haensch, Gertrud Maria; Zeier, Martin; Andrássy, K.; Schwenger, Vedat

doi:10.1093/ndt/gfm353

Cited by 20 publications

(23 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The decrease of CRP or procalcitonin in Goodpasture syndrome for instance is thought to be associated with a more favorable outcome [12]. However, our results suggest that TPE decreases CRP and procalcitonin.…”

Section: Discussioncontrasting

confidence: 57%

Therapeutic Plasma Exchange Decreases Levels of Routinely Used Cardiac and Inflammatory Biomarkers

et al. 2012

View full text Add to dashboard Cite

BackgroundTherapeutic plasma exchange (TPE) plays a key role in the management of various diseases, from thrombotic thrombocytopenic purpura and Goodpasture's syndrome to cardiac allograft rejection. In many of these disease states cardiac and inflammatory involvement is common and biomarkers are routinely used for diagnosis or assessment of therapeutic success. The effect of TPE on biomarkers used in the clinical routine has not been investigated.MethodsTPE was initiated for established clinical conditions in 21 patients. Troponin T, NT-proBNP, C-reactive protein, procalcitonin and routine chemistry were drawn before and after TPE, as well as before and after the 2nd TPE. The total amount of these markers in the waste bag was also analyzed.ResultsIn 21 patients 42 TPEs were performed. The procedure reduced plasma levels of the examined biomarkers: 23% for NT-proBNP (pre vs. post: 4637±10234 ng/l to 3565±8295 ng/l, p<0.001), 64% for CRP (21.9±47.0 mg/l vs. 7.8±15.8 mg/l, p<0.001) and 31% for procalcitonin (0.39±1.1 µg/l vs. 0.27±0.72 µg/l, p=0.004). TPE also tended to reduce plasma levels of troponin T by about 14% (60.7±175.5 ng/l vs. 52.2±141.3 ng/l), however this difference was not statistical significant (p=0.95). There was a significant correlation between the difference of pre TPE levels to post TPE levels of all examined biomarkers and the total amount of the removed biomarker in the collected removed plasma.ConclusionsTPE significantly reduces plasma levels of inflammatory and cardiac biomarkers. Therefore, post TPE levels of cardiac and inflammatory biomarkers should be viewed with caution.

show abstract

Section: Discussioncontrasting

confidence: 57%

Therapeutic Plasma Exchange Decreases Levels of Routinely Used Cardiac and Inflammatory Biomarkers

et al. 2012

View full text Add to dashboard Cite

show abstract

“…27,28 In systemic vasculitis, organ involvement seems to affect serum procalcitonin levels. 29 Although this explanation is questionable due to the small number of patients studied, the results of this case series suggest that an elevated serum procalcitonin level in this clinical setting does not necessarily indicate infection. 29 No significant accumulation of procalcitonin was found in patients with impaired kidney function; therefore, procalcitonin is an accurate indicator of bacterial infection and sepsis in renal patients.…”

Section: Discussionmentioning

confidence: 73%

“…Therefore, high procalcitonin levels should be interpreted carefully in these patients. 29 No significant accumulation of procalcitonin was found in patients with impaired kidney function; therefore, procalcitonin is an accurate indicator of bacterial infection and sepsis in renal patients. In contrast, patients with GCA had normal serum procalcitonin levels despite high disease activity.…”

Section: Discussionmentioning

confidence: 99%

Serum procalcitonin levels in patients with ankylosing spondylitis

et al. 2014

View full text Add to dashboard Cite

show abstract

“…У 7 больных с синдромом Гудпасчера медиана СРБ равнялась 14,7 нг / мл, а ПКТ -34,1 нг / мл, при этом уровень ПК был значимо повышен у пациентов с жиз-неугрожающими состояниями и нуждающихся в гемо-диализе. Терапия основного заболевания способство-вала снижению уровня ПК [37].…”

Section: васкулитыunclassified