Procalcitonin, as an early biomarker of colorectal anastomotic leak, facilitates enhanced recovery after surgery

Giaccaglia, Valentina; Salvi, Pier Federico; Cunsolo, G.V.; Sparagna, Alessandra; Antonelli, M.; Nigri, Giuseppe; Balducci, Genoveffa; Ziparo, Vincenzo

doi:10.1016/j.jcrc.2014.03.036

Cited by 62 publications

(47 citation statements)

References 33 publications

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“…Raised PCT serum concentration on postoperative days 3 to 5 renders necessary a careful evaluation of the patient before discharge [9]. Similar conclusions had been got in other researches [7,10,14,18]. There are also studies to determine whether PCT in drain fluid can serve as screening tool for AL [19].…”

Section: Procalcitoninsupporting

confidence: 66%

“…Comparison of postoperative serum WBC values did not show any significant differences between AL group and non-AL group until the POD6 [6]. Another two studied got the similar conclusion that WBC was not an ideal biomarker for predicting AL [10,14]. Therefore, further studies should be performed to explore the value of WBC in the early diagnosis of AL.…”

Section: White Blood Cell Countmentioning

confidence: 87%

“…The cut-off value of 140 mg/L on POD3 maximized the sensitivity (78%) and specificity (86%) of serum CRP in assessing the risk of leakage [6]. Serum CRP has been evaluated in other 11 studies [7][8][9][10][11][12][13][14][15][16][17]. In general, the CRP level was raised significantly days before the diagnosis of AL.…”

Section: C-reactive Proteinmentioning

confidence: 99%

“…Liu et al try to demonstrate the value of potential of hydrogen (PH) of pelvic drainage in the identification of increased risk of AL after anterior resection for rectal cancer with a double stapling technique. They got positive result and concluded that an early and persistent decline of PH value of pelvic CRP (sensitivity 68%, specilficity 74%); WBC (sensitivity 90%, specilficity 62%) alvaro, 2013, [9] PCT (POD5, cutoff value:0.31 ng/ml) Sensitivity 72%, specilficity 100% Giaccaglia, 2014, [10] PCT (POD3 and POD5)…”

Section: Some Uncommon Markers In Drainagementioning

confidence: 99%

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The value of biomarkers in early diagnosis of anastomotic leak following colorectal tumor resection: a review of the literature between 2012 and 2017

Ge¹,

Chen²

2017

Oncotarget

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Anastomotic leakage (AL) is one of the most serious complications of colorectal resection, causing sepsis, reducing overall in-hospital survival and increasing the risk of local and distant recurrences. So, early diagnosis of AL is very important. To improve the early diagnosis of AL following colorectal resection, a number of studies have investigated potential biomarkers to predict AL. In this review, we summarized the biomarkers, which had been shown to be useful in early diagnosis of AL. The results showed that c-reactive protein (CRP), procalcitonin (PCT), white blood cell count (WBC), cytokines, and so on were hot study biomarkers, which were proved to be reliable predictors of AL. Besides, drainage indexes such as microbiological study, potential of hydrogen (PH), carcinoembryonic antigen (CEA), and so on also helped to indicate early AL. Although there have been many studies on this field, rigorous homogeneous and prospective trials are demanded to explore ideal biomarkers to early diagnose AL.

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Section: Procalcitoninsupporting

confidence: 66%

Section: White Blood Cell Countmentioning

confidence: 87%

Section: C-reactive Proteinmentioning

confidence: 99%

Section: Some Uncommon Markers In Drainagementioning

confidence: 99%

See 2 more Smart Citations

The value of biomarkers in early diagnosis of anastomotic leak following colorectal tumor resection: a review of the literature between 2012 and 2017

Ge¹,

Chen²

2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…7 Therefore, PCT levels are used to monitor the course of systemic bacterial and fungal infections and to tailor the therapeutic interventions more efficiently. 8,9 Considering the good results from our pilot study, 10 we decided to design this multicentric study (http://clinicaltrials.gov/show/NCT01817647) in the aim to confirm the strength of PCT as an early predictor of anastomotic leak and to fix the best cutoff values for an early discharge of patients, according to enhanced recovery after surgery protocols.…”

mentioning

confidence: 99%