Procalcitonin as a marker for the diagnosis of sepsis

Chivate, Chidanand G.; Belwalkar, G. J.; Limaye, Ramchandra Prabhakar; Patil, Rahul V.

doi:10.18203/2320-6012.ijrms20160812

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…If procalcitonin concentration is below 0.2 ng/mL, it indicates no sepsis or systemic inflammation; however, it is defined as sepsis if the concentration is between 2 and 10 ng/mL, and severe sepsis when the concentration is above 10 ng/mL. In addition, the greater the procalcitonin concentration, the greater the mortality rates (Chivate et al 2016 ; Matur et al 2017 ). Neopterin, another important biomarker, is a metabolic compound of guanosine triphosphate, which chemically belongs to pteridine group.…”

Section: Introductionmentioning

confidence: 99%

Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis

Akyüz

Gökçe

2021

Trop Anim Health Prod

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This study aims to determine how neopterin, procalcitonin, biochemical and hematological parameters change during treatment of calves with neonatal sepsis. A total of 25 calves divided into two groups. Sepsis group was composed of 15 newborn calves aged 0–10 days which met neonatal sepsis criteria, but did not receive any treatment. Control group included 10 healthy calves aged 0–10 days. Clinical examinations (respiratory rate, rectal temperature, heart rate, capillary refill time, sucking reflex) were performed at certain times before (0th h) and during (12th, 24th, 48th, and 72th h) the treatment. The blood was taken from the jugular vein from the sepsis group before (0th h) and during the treatment (12th, 24th, 48th, and 72nd h) and once from the control group. Procalcitonin pretreatment (0th h) and control group concentrations were found as 178.08 ± 2.4 (pg/mL) and 42.78 ± 1.25 (pg/mL), respectively ( p < 0.001). Neopterin pretreatment (0th h) and control group concentrations were determined as 14.44 ± 0.30 (ng/mL) and 3.63 ± 0.29 (ng/mL), respectively ( p < 0.001). As a result, neopterin and procalcitonin concentration decreased along with the treatment, confirming the presence of sepsis in calves and suggesting that sepsis could be a prognostic indicator. Therefore, both procalcitonin and neopterin can be prognostic and diagnostic in calves with sepsis.

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Section: Introductionmentioning

confidence: 99%

Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis

Akyüz

Gökçe

2021

Trop Anim Health Prod

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“…PCT regulation will change during infection. There will be a massive release of PCT into the bloodstream depending on the severity of sepsis [9]. Serum PCT levels rise as early as 3 h after bacterial infection, reaching a peak around 20 h. Higher levels of PCT are associated with the severity of sepsis [5].…”

Section: Introductionmentioning

confidence: 99%

Role of Procalcitonin and C-reactive Protein as Marker of Sepsis in Major Burn Patients: A Systematic Review and Meta-analysis

Permatasari

Sanjaya

Widiana

et al. 2021

Open Access Maced J Med Sci

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AIM: Although absolute values for C-reactive protein (CRP) and procalcitonin (PCT) are well known to predict sepsis, it remains unclear how their diagnostic value in major burn patients as metabolic changes in burn patient mimic signs and symptoms for sepsis. This paper attempts to clarify these points for both of the markers. METHODS: A comprehensive literature search of PubMed, Scopus, DOAJ, Web of Science, and the Cochrane Library databases for studies published up to June 1, 2020, that evaluated PCT and/or CRP as a marker for diagnosing sepsis in burn patients was conducted. Review Manager 5.3 was used to analyze the data. RESULTS: A total of 11 literatures were obtained. The combined sensitivity and specificity for PCT as assessed by meta-analysis were 88% and 89%, respectively. The combined sensitivity and specificity of CRP were described as 85.5% and 57.5%, respectively. Meta-analysis cannot be performed for CRP parameters because there are only two literatures that include CRP diagnostic test values. DISCUSSION: PCT and CRP have additional diagnostic value for sepsis in patients with major burns. The pooled sensitivity and specificity of PCT are excellent. Although the difference in sensitivity between PCT and CRP is not very large, there are distinct differences in specificity. A low CRP specificity value will show many “false positives” when CRP is used as a biomarker. CONCLUSION: PCT provides a better diagnostic value than CRP in cases of sepsis in major burn patients. More study on combination of biomarker, clinical presentation, and microbial culture for diagnosing sepsis are needed. Further large-scale research with cohort or case control design should be done.

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“…[ 3 ] The isolation of microorganisms is considered to be the gold standard for the diagnosis of sepsis. [ 4 ] However, blood culture positivity can be detected approximately 30% of bacteremic patients and positive blood cultures may not be identified until 48–72 h.[ 4 5 ] The sensitivity and specificity of routine laboratory tests are inadequate to discriminate between infectious and noninfectious conditions.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Procalcitonin in Predicting Bacteremia in Intensive Care Unit

Demırdal¹,

Şen²,

Nemli³

2018

Indian Journal of Critical Care Medicine

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Background and Aims:Several biomarkers are used in the diagnosis of bacteremia. Procalcitonin (PCT) is more specific than other biomarkers in differentiating bacterial and nonbacterial inflammation. It was aimed to evaluate the diagnostic and prognostic value of PCT in bacteremic patients in Intensive Care Unit (ICU).Materials and Methods:A total of 156 patients diagnosed with noninfectious systemic inflammatory response syndrome, sepsis, and severe sepsis/septic shock in ICU between December 2014 and July 2015 were evaluated in this prospective cohort study.Results:The study group consisted of 64 (41%) bacteremic patients and the control group consisted of 92 (59%) nonbacteremic patients. The overall mortality rate was 60.3%. Although PCT levels in the bacteremic group (11.9 ± 21.5 ng/dL) were higher than nonbacteremic group (5.9 ± 11.5 ng/dL), this difference was not significant (P = 0.168). The mean levels of PCT in bacteremic patients with Gram-negative bacteria were 16.3 ± 27.6 ng/dL, whereas Gram-positive bacteria were 7.3 ± 10.7 ng/dL (P = 0.145). The mean PCT levels were significantly higher in nonsurvivors compared to survivors (10.1 ± 18.0 vs. 5.7 ± 13.7 ng/dL; P < 0.001).Conclusions:PCT may be an effective biomarker for diagnosing sepsis and predicting disease severity and mortality. There is a need for further well-designed studies to confirm the diagnostic and prognostic value of PCT in septic patients in critical care.

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Procalcitonin as a marker for the diagnosis of sepsis

Cited by 8 publications

References 10 publications

Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis

Neopterin, procalcitonin, clinical biochemistry, and hematology in calves with neonatal sepsis

Role of Procalcitonin and C-reactive Protein as Marker of Sepsis in Major Burn Patients: A Systematic Review and Meta-analysis

Diagnostic Value of Procalcitonin in Predicting Bacteremia in Intensive Care Unit

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